YFL054C_p

Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL054C / YFL054C

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.00|P-value:9.82E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.91|P-value:1.93E-7 ID:SGTC_209|Compound:4077-0173|FD-Score:3.93|P-value:2.28E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.00|P-value:9.89E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.09|P-value:7.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.12|P-value:6.13E-4 ID:SGTC_433|Compound:pimozide|FD-Score:8.02|P-value:4.86E-17 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.62|P-value:8.71E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.84|P-value:3.49E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.07|P-value:7.65E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.37|P-value:2.39E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.28|P-value:4.65E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.92|P-value:2.43E-5 ID:SGTC_1885|Compound:st057546|FD-Score:-3.24|P-value:4.06E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.18|P-value:5.08E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.08|P-value:7.24E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.34|P-value:2.68E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.78|P-value:4.38E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.13|P-value:5.92E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.96|P-value:1.99E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.11|P-value:1.01E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-5.03|P-value:1.03E-7 ID:SGTC_2870|Compound:9038528|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-5.35|P-value:1.66E-8 ID:SGTC_2876|Compound:9059903|FD-Score:3.05|P-value:7.78E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.06|P-value:1.31E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.43|P-value:2.19E-6 ID:SGTC_3309|Compound:9129340|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.14|P-value:5.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.37|P-value:2.50E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.06|P-value:1.39E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.00|P-value:9.82E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.91|P-value:1.93E-7 ID:SGTC_209|Compound:4077-0173|FD-Score:3.93|P-value:2.28E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.00|P-value:9.89E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.09|P-value:7.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.12|P-value:6.13E-4 ID:SGTC_433|Compound:pimozide|FD-Score:8.02|P-value:4.86E-17 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.62|P-value:8.71E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.84|P-value:3.49E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.07|P-value:7.65E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.37|P-value:2.39E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.23|P-value:4.01E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.28|P-value:4.65E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.85|P-value:3.28E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.92|P-value:2.43E-5 ID:SGTC_1885|Compound:st057546|FD-Score:-3.24|P-value:4.06E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.18|P-value:5.08E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.08|P-value:7.24E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.34|P-value:2.68E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.78|P-value:4.38E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.13|P-value:5.92E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.96|P-value:1.99E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.11|P-value:1.01E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-5.03|P-value:1.03E-7 ID:SGTC_2870|Compound:9038528|FD-Score:-3.09|P-value:7.08E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-5.35|P-value:1.66E-8 ID:SGTC_2876|Compound:9059903|FD-Score:3.05|P-value:7.78E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.06|P-value:1.31E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.43|P-value:2.19E-6 ID:SGTC_3309|Compound:9129340|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.14|P-value:5.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.37|P-value:2.50E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.06|P-value:1.39E-5

Top fitness defect scores for YFL054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_433 pimozide 8.02 108.0 µM 4.86E-17 1 5.17E-16
2 SGTC_3108 9121785 4.43 49.5 µM 2.19E-6 5 4.68E-6
3 SGTC_1022 4477-0945 4.28 21.3 µM 4.65E-6 16 9.45E-6
4 SGTC_2750 bromebric acid 4.11 70.2 µM 1.01E-5 25 1.95E-5
5 SGTC_2976 9009005 4.06 19.5 µM 1.31E-5 26 2.50E-5
6 SGTC_2699 st077704 3.96 54.6 µM 1.99E-5 endomembrane recycling 48 3.69E-5
7 SGTC_209 4077-0173 3.93 175.6 µM 2.28E-5 10 4.18E-5
8 SGTC_1453 4237-0541 3.92 195.0 µM 2.43E-5 heme biosynthesis & mitochondrial translocase 29 4.44E-5
9 SGTC_1433 4060-0023 3.85 7.6 µM 3.28E-5 tubulin folding & SWR complex 20 5.88E-5
10 SGTC_922 1866-0035 3.84 480.0 µM 3.49E-5 excess fatty acid 63 6.24E-5
11 SGTC_2537 larixol 3.78 68.9 µM 4.38E-5 27 7.72E-5
12 SGTC_693 4161-2696 3.62 114.0 µM 8.71E-5 14 1.47E-4
13 SGTC_495 decylubiquinone 3.56 155.0 µM 1.13E-4 copper-dependent oxidative stress 37 1.88E-4
14 SGTC_1450 4112-4260 3.55 37.6 µM 1.14E-4 calcium & mitochondrial duress 40 1.89E-4
15 SGTC_998 3996-0085 3.37 177.0 µM 2.39E-4 41 3.77E-4
16 SGTC_2456 5770359 3.34 74.5 µM 2.68E-4 32 4.20E-4
17 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.33 100.0 µM 2.74E-4 60S ribosome export 46 4.29E-4
18 SGTC_3309 9129340 3.32 25.8 µM 2.85E-4 35 4.45E-4
19 SGTC_1182 1222-0449 3.26 220.0 µM 3.62E-4 31 5.57E-4
20 SGTC_1007 4101-0031 3.23 70.0 µM 4.01E-4 37 6.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.72E-9 YOL062C APM4 hom Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
0.090 1.81E-7 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.089 2.48E-7 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.084 1.04E-6 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.083 1.31E-6 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.079 4.20E-6 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.077 8.47E-6 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.076 1.19E-5 YPL103C FMP30 hom Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D
0.073 2.07E-5 YOL026C MIM1 het Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
0.071 3.80E-5 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.071 3.81E-5 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.070 4.93E-5 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.070 5.22E-5 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.069 6.61E-5 YMR061W RNA14 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.068 7.64E-5 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein