YFL055W / AGP3

Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL055W / AGP3

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.76|P-value:2.12E-5 ID:SGTC_252|Compound:miconazole|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.28|P-value:1.82E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.08|P-value:3.17E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.72|P-value:2.53E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.54|P-value:4.27E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:5.02|P-value:2.13E-8 ID:SGTC_1741|Compound:st038134|FD-Score:3.61|P-value:4.35E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.19|P-value:2.02E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-2.97|P-value:4.88E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.73|P-value:2.48E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.17|P-value:2.85E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.78|P-value:1.94E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.56|P-value:5.42E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.21|P-value:2.26E-6 ID:SGTC_2284|Compound:7945075|FD-Score:3.00|P-value:5.53E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.97|P-value:5.58E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.87|P-value:3.49E-8 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:2.83E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.41|P-value:7.69E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.11|P-value:3.80E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:2.95|P-value:6.68E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.79|P-value:8.44E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-2.97|P-value:4.79E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.03|P-value:3.75E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.60|P-value:4.39E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.76|P-value:2.12E-5 ID:SGTC_252|Compound:miconazole|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.28|P-value:1.82E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.08|P-value:3.17E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.72|P-value:2.53E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.54|P-value:4.27E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.22|P-value:2.37E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:5.02|P-value:2.13E-8 ID:SGTC_1741|Compound:st038134|FD-Score:3.61|P-value:4.35E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.19|P-value:2.02E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-2.97|P-value:4.88E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.73|P-value:2.48E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.17|P-value:2.85E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.78|P-value:1.94E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.56|P-value:5.42E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.21|P-value:2.26E-6 ID:SGTC_2284|Compound:7945075|FD-Score:3.00|P-value:5.53E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.97|P-value:5.58E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.87|P-value:3.49E-8 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:2.83E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.41|P-value:7.69E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.11|P-value:3.80E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:2.95|P-value:6.68E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.79|P-value:8.44E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-2.97|P-value:4.79E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.03|P-value:3.75E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.60|P-value:4.39E-5

Top fitness defect scores for YFL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1376 2910-0861 5.02 41.3 µM 2.13E-8 6 2.57E-7
2 SGTC_2564 betulinic acid 4.79 100.0 µM 8.44E-8 16 8.15E-7
3 SGTC_2282 7944268 4.21 200.0 µM 2.26E-6 RPP1 & pyrimidine depletion 23 1.29E-5
4 SGTC_2514 salinomycin 4.11 42.7 µM 3.80E-6 41 2.00E-5
5 SGTC_2126 5251174 3.78 33.9 µM 1.94E-5 42 7.88E-5
6 SGTC_68 0986-0284 3.76 82.8 µM 2.12E-5 81 8.51E-5
7 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.73 62.6 µM 2.48E-5 TSC3-RPN4 19 9.69E-5
8 SGTC_555 4296-0685 3.72 37.0 µM 2.53E-5 ergosterol biosynthesis 14 9.87E-5
9 SGTC_1741 st038134 3.61 10.2 µM 4.35E-5 38 1.56E-4
10 SGTC_3327 9140648 3.60 26.9 µM 4.39E-5 17 1.57E-4
11 SGTC_2281 7943571 3.56 200.0 µM 5.42E-5 19 1.88E-4
12 SGTC_301 4119-0100 3.28 24.5 µM 1.82E-4 NEO1 113 5.21E-4
13 SGTC_1333 1482-0047 3.22 286.0 µM 2.37E-4 42 6.52E-4
14 SGTC_632 0781-2353 3.21 4.7 µM 2.37E-4 Golgi 78 6.53E-4
15 SGTC_2404 5161160 3.17 200.0 µM 2.83E-4 46 7.58E-4
16 SGTC_2030 5175110 3.17 200.0 µM 2.85E-4 Golgi 52 7.64E-4
17 SGTC_2284 7945075 3.00 39.2 µM 5.53E-4 mitochondrial processes 72 0.00134
18 SGTC_2516 gossypol 2.95 71.5 µM 6.68E-4 59 0.00157
19 SGTC_252 miconazole 2.86 1.3 nM 9.45E-4 ergosterol depletion effects on membrane 96 0.00211
20 SGTC_359 0081-0058 2.81 15.9 µM 0.00114 60S ribosome export 119 0.00247

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.31E-22 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.133 1.28E-14 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.119 4.44E-12 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.118 7.63E-12 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.117 1.27E-11 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.116 1.99E-11 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.115 2.77E-11 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.105 9.85E-10 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.105 1.12E-9 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.104 1.47E-9 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.102 3.63E-9 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.099 8.89E-9 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.098 1.44E-8 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.095 3.05E-8 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.095 3.22E-8 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p