YFR001W / LOC1

Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR001W / LOC1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.23|P-value:6.40E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.41|P-value:3.24E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.28|P-value:5.35E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.39|P-value:5.23E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:3.29|P-value:5.18E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.87|P-value:2.16E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.34|P-value:4.23E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.85|P-value:5.83E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.81|P-value:3.57E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.39|P-value:5.14E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:3.16|P-value:8.18E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.08|P-value:2.10E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.04|P-value:2.54E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.32|P-value:4.59E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.00|P-value:8.16E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.15|P-value:8.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.13|P-value:1.74E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.18|P-value:7.58E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.99|P-value:3.12E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.15|P-value:1.54E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-2.95|P-value:9.79E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.15|P-value:1.58E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.25|P-value:3.32E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.37|P-value:5.78E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.24|P-value:6.25E-4 ID:SGTC_1899|Compound:st063254|FD-Score:4.71|P-value:1.07E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:3.10E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.17|P-value:1.47E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-3.17|P-value:4.41E-4 ID:SGTC_2270|Compound:7924575|FD-Score:4.08|P-value:2.15E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.02|P-value:2.76E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.14|P-value:8.82E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-4.51|P-value:1.40E-6 ID:SGTC_2435|Compound:5706476|FD-Score:-2.98|P-value:8.94E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.46|P-value:2.72E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.14|P-value:1.64E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.19|P-value:1.32E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.85|P-value:5.74E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.10|P-value:1.99E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.23|P-value:3.61E-4 ID:SGTC_3009|Compound:9080819|FD-Score:5.16|P-value:1.02E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.38|P-value:3.64E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.02|P-value:7.80E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.72|P-value:5.25E-5 ID:SGTC_3043|Compound:9092303|FD-Score:5.42|P-value:2.37E-8 ID:SGTC_3240|Compound:9133527|FD-Score:3.94|P-value:3.90E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.81|P-value:3.58E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.91|P-value:4.45E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.36|P-value:2.19E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.23|P-value:6.40E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.41|P-value:3.24E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.28|P-value:5.35E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.39|P-value:5.23E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:3.29|P-value:5.18E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.87|P-value:2.16E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.34|P-value:4.23E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.85|P-value:5.83E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.81|P-value:3.57E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.39|P-value:5.14E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:3.16|P-value:8.18E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.08|P-value:2.10E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.04|P-value:2.54E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.32|P-value:4.59E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.00|P-value:8.16E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.15|P-value:8.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.13|P-value:1.74E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.18|P-value:7.58E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.99|P-value:3.12E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.15|P-value:1.54E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-2.95|P-value:9.79E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.15|P-value:1.58E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.25|P-value:3.32E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.37|P-value:5.78E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.24|P-value:6.25E-4 ID:SGTC_1899|Compound:st063254|FD-Score:4.71|P-value:1.07E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:3.10E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.17|P-value:1.47E-5 ID:SGTC_2073|Compound:5212005|FD-Score:-3.17|P-value:4.41E-4 ID:SGTC_2270|Compound:7924575|FD-Score:4.08|P-value:2.15E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.02|P-value:2.76E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.14|P-value:8.82E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-4.51|P-value:1.40E-6 ID:SGTC_2435|Compound:5706476|FD-Score:-2.98|P-value:8.94E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.46|P-value:2.72E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.14|P-value:1.64E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.19|P-value:1.32E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.85|P-value:5.74E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.10|P-value:1.99E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.23|P-value:3.61E-4 ID:SGTC_3009|Compound:9080819|FD-Score:5.16|P-value:1.02E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.38|P-value:3.64E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.02|P-value:7.80E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.72|P-value:5.25E-5 ID:SGTC_3043|Compound:9092303|FD-Score:5.42|P-value:2.37E-8 ID:SGTC_3240|Compound:9133527|FD-Score:3.94|P-value:3.90E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.81|P-value:3.58E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.91|P-value:4.45E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.36|P-value:2.19E-4

Top fitness defect scores for YFR001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3043 9092303 5.42 49.5 µM 2.37E-8 2 2.99E-8
2 SGTC_3009 9080819 5.16 71.4 µM 1.02E-7 5 1.24E-7
3 SGTC_1899 st063254 4.71 59.6 µM 1.07E-6 5 1.22E-6
4 SGTC_563 tetrahydrosecaminediol 4.39 614.0 µM 5.14E-6 amide catabolism 10 5.59E-6
5 SGTC_118 0083-0097 4.39 135.3 µM 5.23E-6 translation 92 5.68E-6
6 SGTC_1887 st057648 4.37 70.8 µM 5.78E-6 4 6.27E-6
7 SGTC_2851 9015922 4.23 71.4 µM 1.07E-5 28 1.15E-5
8 SGTC_2566 crystal violet carbinol 4.19 226.0 nM 1.32E-5 35 1.40E-5
9 SGTC_1919 st067113 4.17 52.3 µM 1.47E-5 TSC3-RPN4 25 1.55E-5
10 SGTC_1466 k213-0079 4.15 57.5 µM 1.54E-5 14 1.63E-5
11 SGTC_1870 st057514 4.15 26.5 µM 1.58E-5 RSC & ERG11 20 1.67E-5
12 SGTC_2564 betulinic acid 4.14 100.0 µM 1.64E-5 28 1.74E-5
13 SGTC_1204 4049-0315 4.13 18.3 µM 1.74E-5 23 1.84E-5
14 SGTC_2759 disulfiram 4.10 3.4 µM 1.99E-5 23 2.09E-5
15 SGTC_881 0833-0569 4.08 170.0 µM 2.10E-5 24 2.21E-5
16 SGTC_2270 7924575 4.08 90.9 µM 2.15E-5 RPP1 & pyrimidine depletion 11 2.26E-5
17 SGTC_1364 1653-0028 4.07 37.6 µM 2.26E-5 19 2.37E-5
18 SGTC_949 1165-0505 4.04 146.0 µM 2.54E-5 16 2.65E-5
19 SGTC_2293 7624732 4.02 200.0 µM 2.76E-5 26 2.88E-5
20 SGTC_1446 4239-0190 3.99 62.0 µM 3.12E-5 36 3.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.10E-10 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.091 1.29E-7 YGL076C RPL7A hom Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
0.089 2.22E-7 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.087 4.02E-7 YDL075W RPL31A hom Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
0.086 6.11E-7 YBR278W DPB3 hom Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication
0.083 1.33E-6 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.083 1.57E-6 YHR021C RPS27B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication
0.081 2.42E-6 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.081 2.45E-6 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.081 2.75E-6 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.073 2.02E-5 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.072 2.65E-5 YPR076W_d YPR076W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.89E-5 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.072 2.91E-5 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.072 3.23E-5 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay