YFR002W / NIC96

Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR002W / NIC96

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.72|P-value:2.42E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.95|P-value:1.28E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:8.35|P-value:3.38E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:7.61|P-value:9.20E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:4.79|P-value:2.00E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.77|P-value:2.10E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.31|P-value:1.56E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:5.18|P-value:6.43E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.25|P-value:5.12E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.77|P-value:2.11E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.50|P-value:4.36E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.51|P-value:4.22E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.34|P-value:6.72E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.92|P-value:1.56E-7 ID:SGTC_1891|Compound:st059073|FD-Score:-4.23|P-value:8.83E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.21|P-value:9.15E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.52|P-value:4.22E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.66|P-value:2.87E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:8.84|P-value:3.11E-11 ID:SGTC_2302|Compound:7771753|FD-Score:6.06|P-value:3.67E-6 ID:SGTC_2339|Compound:9000433|FD-Score:6.89|P-value:1.73E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.97|P-value:1.27E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:5.72E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.97|P-value:1.20E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.86|P-value:1.64E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.51|P-value:4.32E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.04|P-value:9.82E-5 ID:SGTC_2922|Compound:7999257|FD-Score:4.99|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:5.44|P-value:2.87E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-5.62|P-value:1.63E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.72|P-value:2.42E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.95|P-value:1.28E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:8.35|P-value:3.38E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:7.61|P-value:9.20E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:4.79|P-value:2.00E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.77|P-value:2.10E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.31|P-value:1.56E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:5.18|P-value:6.43E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.25|P-value:5.12E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.77|P-value:2.11E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.50|P-value:4.36E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.51|P-value:4.22E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.34|P-value:6.72E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.92|P-value:1.56E-7 ID:SGTC_1891|Compound:st059073|FD-Score:-4.23|P-value:8.83E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.21|P-value:9.15E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.52|P-value:4.22E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.66|P-value:2.87E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:8.84|P-value:3.11E-11 ID:SGTC_2302|Compound:7771753|FD-Score:6.06|P-value:3.67E-6 ID:SGTC_2339|Compound:9000433|FD-Score:6.89|P-value:1.73E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.97|P-value:1.27E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:5.72E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.97|P-value:1.20E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.86|P-value:1.64E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.51|P-value:4.32E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.04|P-value:9.82E-5 ID:SGTC_2922|Compound:7999257|FD-Score:4.99|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:5.44|P-value:2.87E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-5.62|P-value:1.63E-5

Top fitness defect scores for YFR002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2232 chlorophetanol 8.84 41.5 µM 3.11E-11 TRP & mitochondrial translation 2 4.62E-19 1.61
2 SGTC_159 3970-0959 8.35 50.0 µM 3.38E-10 5 3.49E-17 0.89
3 SGTC_168 3970-0862 7.61 530.5 µM 9.20E-9 10 1.37E-14 0.15
4 SGTC_2422 chlorphenesin carbamate 6.97 384.2 µM 1.27E-7 1 1.55E-12 2.18
5 SGTC_1652 st011932 6.92 78.0 µM 1.56E-7 RSC complex & mRNA processing 18 2.26E-12 0.17
6 SGTC_2339 9000433 6.89 200.0 µM 1.73E-7 1 2.72E-12 1.79
7 SGTC_445 e6 berbamine 6.31 66.0 µM 1.56E-6 NEO1-PIK1 14 1.43E-10 0.12
8 SGTC_2302 7771753 6.06 200.0 µM 3.67E-6 2 6.64E-10 1.30
9 SGTC_2990 9074105 5.44 71.4 µM 2.87E-5 4 2.64E-8 1.58
10 SGTC_673 1082-0474 5.25 110.0 µM 5.12E-5 RSC complex & mRNA processing 32 7.43E-8 0.09
11 SGTC_562 3772-2733 5.18 112.0 µM 6.43E-5 ERG2 7 1.12E-7 0.23
12 SGTC_2802 7925815 5.04 54.5 µM 9.82E-5 3 2.37E-7 0.38
13 SGTC_2922 7999257 4.99 32.5 µM 1.14E-4 4 3.08E-7 0.69
14 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.97 100.0 µM 1.20E-4 1 3.40E-7 1.08
15 SGTC_150 3970-0969 4.95 77.2 µM 1.28E-4 8 3.80E-7 0.24
16 SGTC_2762 leflunomide 4.86 42.1 µM 1.64E-4 2 5.94E-7 0.84
17 SGTC_227 fluconazole 4.79 33.5 µM 2.00E-4 azole & statin 37 8.40E-7 0.05
18 SGTC_377 3970-0964 4.77 33.1 µM 2.10E-4 4 9.18E-7 0.58
19 SGTC_724 3910-0327 4.77 137.0 µM 2.11E-4 ERG2 1 9.24E-7 0.57
20 SGTC_2086 5274770 4.66 176.6 µM 2.87E-4 6 1.60E-6 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.15E-32 YJR042W NUP85 het Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
0.151 1.83E-18 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.144 5.34E-17 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.141 2.13E-16 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.137 1.30E-15 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.136 2.25E-15 YJL202C_d YJL202C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
0.123 6.96E-13 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.118 7.43E-12 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.113 5.23E-11 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.111 1.12E-10 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.108 4.25E-10 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.104 1.48E-9 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.103 2.47E-9 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.100 5.50E-9 YOR132W VPS17 hom Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
0.098 1.17E-8 YLR197W NOP56 het Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects