YFR003C / YPI1

Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR003C / YPI1

Click on Significant Values for Screen Details ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.34|P-value:4.90E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.41|P-value:3.77E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.16|P-value:8.16E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:5.05|P-value:2.38E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.16|P-value:7.99E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.39|P-value:4.17E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.43|P-value:3.12E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.63|P-value:1.71E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.87|P-value:5.61E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.44|P-value:5.73E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-5.59|P-value:1.61E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:-5.01|P-value:3.67E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:-5.29|P-value:8.62E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.25|P-value:6.64E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.21|P-value:1.59E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.26|P-value:1.27E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.29|P-value:1.14E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.61|P-value:1.58E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.27|P-value:5.46E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.87|P-value:6.59E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.44|P-value:3.01E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.23|P-value:6.23E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.36|P-value:4.55E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.19|P-value:8.14E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-4.45|P-value:5.59E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.22|P-value:7.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.29|P-value:6.68E-8 ID:SGTC_2585|Compound:alliin|FD-Score:-4.02|P-value:3.64E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.14|P-value:9.72E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.96|P-value:4.67E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.44|P-value:3.37E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.66|P-value:2.03E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.59|P-value:2.41E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-5.08|P-value:2.57E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.34|P-value:4.90E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.41|P-value:3.77E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.16|P-value:8.16E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:5.05|P-value:2.38E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.16|P-value:7.99E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.39|P-value:4.17E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.43|P-value:3.12E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.63|P-value:1.71E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.87|P-value:5.61E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.44|P-value:5.73E-6 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-5.59|P-value:1.61E-8 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:-5.01|P-value:3.67E-7 ID:SGTC_1236|Compound:0330-0013|FD-Score:-5.29|P-value:8.62E-8 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.25|P-value:6.64E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.21|P-value:1.59E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.26|P-value:1.27E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.29|P-value:1.14E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.61|P-value:1.58E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.27|P-value:5.46E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.87|P-value:6.59E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.50|P-value:2.74E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.44|P-value:3.01E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.23|P-value:6.23E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.36|P-value:4.55E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.19|P-value:8.14E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-4.45|P-value:5.59E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.22|P-value:7.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.29|P-value:6.68E-8 ID:SGTC_2585|Compound:alliin|FD-Score:-4.02|P-value:3.64E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.14|P-value:9.72E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.96|P-value:4.67E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.44|P-value:3.37E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.66|P-value:2.03E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.59|P-value:2.41E-6 ID:SGTC_3139|Compound:9095020|FD-Score:-5.08|P-value:2.57E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.67|P-value:1.25E-4

Top fitness defect scores for YFR003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2581 avocatin a 5.29 64.0 µM 6.68E-8 sphingolipid biosynthesis & PDR1 3 5.95E-8 1.01
2 SGTC_812 4251-0442 5.05 148.0 µM 2.38E-7 1 2.15E-7 1.02
3 SGTC_2969 9091408 4.59 28.7 µM 2.41E-6 4 2.23E-6 0.56
4 SGTC_1131 3454-3128 3.87 32.3 µM 5.61E-5 15 5.38E-5 0.04
5 SGTC_3272 9137413 3.67 49.5 µM 1.25E-4 10 1.21E-4 0.04
6 SGTC_1207 2099-0101 3.65 141.0 µM 1.37E-4 5 1.32E-4 0.15
7 SGTC_1747 st037496 3.61 66.6 µM 1.58E-4 13 1.53E-4 0.10
8 SGTC_1674 st016616 3.57 23.6 µM 1.85E-4 11 1.79E-4 0.03
9 SGTC_2654 protoveratrine a 3.57 100.0 µM 1.85E-4 7 1.80E-4 0.08
10 SGTC_1991 st073000 3.44 8.9 µM 3.01E-4 NEO1 20 2.93E-4 0.02
11 SGTC_960 1222-0186 3.43 7.7 µM 3.12E-4 16 3.04E-4 0.06
12 SGTC_1211 1056-0033 3.32 32.3 µM 4.67E-4 10 4.56E-4 0.07
13 SGTC_1870 st057514 3.27 26.5 µM 5.46E-4 RSC & ERG11 14 5.35E-4 0.05
14 SGTC_2405 ticlatone 3.23 3.5 µM 6.23E-4 26 6.11E-4 0.00
15 SGTC_1648 st011736 3.21 69.8 µM 6.79E-4 PDR1 6 6.66E-4 0.01
16 SGTC_877 0771-0151 3.16 33.1 µM 7.99E-4 6 7.85E-4 0.01
17 SGTC_265 mycophenolic acid 3.16 32.9 µM 8.16E-4 RPP1 & pyrimidine depletion 10 8.02E-4 0.13
18 SGTC_1975 st070967 3.08 30.8 µM 0.00105 27 0.00104 0.03
19 SGTC_1963 st076565 3.07 50.3 µM 0.00107 12 0.00105 0.00
20 SGTC_1766 st045414 3.07 44.8 µM 0.00108 RPP1 & pyrimidine depletion 21 0.00106 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.07E-11 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.110 1.72E-10 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.109 2.26E-10 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.109 2.70E-10 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.099 8.62E-9 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.098 1.17E-8 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.095 3.83E-8 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.093 7.63E-8 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.089 2.13E-7 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.084 1.07E-6 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.084 1.15E-6 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.66E-6 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.082 2.22E-6 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.080 3.81E-6 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.078 5.80E-6 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13