Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YFR005C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.131 | 2.44E-14 | YKR061W | KTR2 | hom | Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication |
0.116 | 1.51E-11 | YNL193W_p | YNL193W_p | hom | Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis |
0.108 | 2.96E-10 | YPL217C | BMS1 | het | GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p |
0.103 | 2.44E-9 | YLR421C | RPN13 | hom | Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress |
0.096 | 2.70E-8 | YMR080C | NAM7 | hom | ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress |
0.093 | 6.34E-8 | YNL047C | SLM2 | hom | Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication |
0.092 | 9.45E-8 | YDL123W | SNA4 | hom | Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated |
0.090 | 1.86E-7 | YPR191W | QCR2 | hom | Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme |
0.089 | 2.09E-7 | YGL066W | SGF73 | hom | SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay |
0.088 | 3.10E-7 | YGL032C | AGA2 | hom | Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds |
0.081 | 2.56E-6 | YNR013C | PHO91 | hom | Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth |
0.080 | 3.99E-6 | YNL237W | YTP1 | hom | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins |
0.079 | 4.49E-6 | YPL001W | HAT1 | hom | Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair |
0.078 | 6.44E-6 | YDR100W | TVP15 | hom | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p |
0.078 | 6.79E-6 | YOR353C | SOG2 | het | Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis |