YFR006W_p

Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR006W / YFR006W

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:3.15|P-value:5.75E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.26|P-value:3.75E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.58|P-value:1.07E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.68|P-value:2.24E-9 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.19|P-value:4.86E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.03|P-value:8.71E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.37|P-value:2.47E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.31|P-value:3.18E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.14|P-value:5.91E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.09|P-value:6.97E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.14|P-value:6.03E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:2.81E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.73|P-value:5.81E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.79|P-value:4.48E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.03|P-value:8.77E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.92|P-value:1.88E-7 ID:SGTC_2122|Compound:5258151|FD-Score:3.22|P-value:4.37E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.21|P-value:4.63E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.96|P-value:2.15E-5 ID:SGTC_2272|Compound:7805186|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_2278|Compound:7948257|FD-Score:-5.53|P-value:5.59E-9 ID:SGTC_2455|Compound:5377712|FD-Score:-3.47|P-value:1.68E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.02|P-value:1.61E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.47|P-value:1.70E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.53|P-value:1.32E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-2.99|P-value:9.98E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.99|P-value:1.26E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.81|P-value:4.19E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2794|Compound:7785382|FD-Score:8.61|P-value:3.11E-19 ID:SGTC_2865|Compound:9030313|FD-Score:3.78|P-value:4.79E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.19|P-value:7.72E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.50|P-value:1.52E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:5.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.11|P-value:1.12E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.07|P-value:7.66E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.38|P-value:2.40E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.49|P-value:1.80E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.23|P-value:4.18E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.04|P-value:8.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.86|P-value:3.31E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.87|P-value:3.23E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.15|P-value:5.75E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:3.26|P-value:3.75E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.58|P-value:1.07E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.68|P-value:2.24E-9 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.19|P-value:4.86E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.03|P-value:8.71E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.37|P-value:2.47E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.31|P-value:3.18E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.14|P-value:5.91E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.09|P-value:6.97E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.14|P-value:6.03E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:2.81E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.73|P-value:5.81E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.79|P-value:4.48E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.03|P-value:8.77E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.92|P-value:1.88E-7 ID:SGTC_2122|Compound:5258151|FD-Score:3.22|P-value:4.37E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.21|P-value:4.63E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.96|P-value:2.15E-5 ID:SGTC_2272|Compound:7805186|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_2278|Compound:7948257|FD-Score:-5.53|P-value:5.59E-9 ID:SGTC_2455|Compound:5377712|FD-Score:-3.47|P-value:1.68E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.02|P-value:1.61E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.47|P-value:1.70E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.53|P-value:1.32E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-2.99|P-value:9.98E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.99|P-value:1.26E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.81|P-value:4.19E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2794|Compound:7785382|FD-Score:8.61|P-value:3.11E-19 ID:SGTC_2865|Compound:9030313|FD-Score:3.78|P-value:4.79E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.19|P-value:7.72E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.50|P-value:1.52E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:5.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.11|P-value:1.12E-5 ID:SGTC_2968|Compound:9090663|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.07|P-value:7.66E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.38|P-value:2.40E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.49|P-value:1.80E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.08|P-value:7.45E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.23|P-value:4.18E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.04|P-value:8.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.86|P-value:3.31E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.87|P-value:3.23E-5

Top fitness defect scores for YFR006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2794 7785382 8.61 27.3 µM 3.11E-19 1 3.77E-18
2 SGTC_996 3970-0799 5.68 1.8 µM 2.24E-9 42 6.76E-9
3 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.99 100.0 µM 1.26E-7 60S ribosome export 9 2.97E-7
4 SGTC_2121 5257820 4.92 149.6 µM 1.88E-7 3 4.34E-7
5 SGTC_2272 7805186 4.57 180.0 µM 1.18E-6 cell wall signaling 13 2.43E-6
6 SGTC_3116 9124943 4.57 49.5 µM 1.18E-6 9 2.43E-6
7 SGTC_3087 9117406 4.49 49.5 µM 1.80E-6 10 3.62E-6
8 SGTC_2866 9034245 4.19 58.4 µM 7.72E-6 6 1.42E-5
9 SGTC_2936 9038235 4.11 15.6 µM 1.12E-5 15 2.02E-5
10 SGTC_2267 7931562 3.96 200.0 µM 2.15E-5 20 3.73E-5
11 SGTC_3290 9121031 3.87 71.4 µM 3.23E-5 14 5.47E-5
12 SGTC_3214 9129694 3.86 49.5 µM 3.31E-5 30 5.59E-5
13 SGTC_2736 butenafine 3.81 14.7 µM 4.19E-5 33 6.98E-5
14 SGTC_1853 st056710 3.79 91.2 µM 4.48E-5 amide catabolism 31 7.43E-5
15 SGTC_2865 9030313 3.78 52.0 µM 4.79E-5 17 7.93E-5
16 SGTC_1993 st073995 3.54 70.8 µM 1.29E-4 31 2.01E-4
17 SGTC_2524 avocatin b 3.53 10.6 µM 1.32E-4 35 2.06E-4
18 SGTC_2793 7325131 3.52 81.8 µM 1.36E-4 22 2.12E-4
19 SGTC_802 4112-3352 3.50 742.0 µM 1.50E-4 33 2.31E-4
20 SGTC_1054 3429-0080 3.37 167.0 µM 2.47E-4 43 3.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 5.59E-33 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.173 4.40E-24 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.143 6.84E-17 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.135 3.88E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.133 1.10E-14 YGL226W MTC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
0.133 1.28E-14 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.128 8.21E-14 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.126 2.59E-13 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.123 9.59E-13 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.123 9.89E-13 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.120 2.66E-12 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.116 1.61E-11 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.116 1.87E-11 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.115 2.41E-11 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.110 1.65E-10 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth