YFR007W / YFH7

Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR007W / YFH7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.90|P-value:1.23E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.56E-51 ID:SGTC_64|Compound:000l-0018|FD-Score:17.30|P-value:7.26E-76 ID:SGTC_67|Compound:0335-0847|FD-Score:8.23|P-value:1.26E-18 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.33|P-value:2.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:14.00|P-value:3.01E-50 ID:SGTC_90|Compound:0870-0863|FD-Score:4.76|P-value:2.16E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:16.60|P-value:4.82E-70 ID:SGTC_107|Compound:0358-0022|FD-Score:6.89|P-value:1.34E-13 ID:SGTC_114|Compound:0364-0001|FD-Score:3.26|P-value:2.68E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.00|P-value:2.37E-43 ID:SGTC_142|Compound:0335-0849|FD-Score:13.00|P-value:1.02E-43 ID:SGTC_158|Compound:k038-0087|FD-Score:14.10|P-value:5.29E-51 ID:SGTC_200|Compound:k038-0079|FD-Score:3.52|P-value:9.35E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.67|P-value:9.19E-10 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.19|P-value:3.65E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:7.32|P-value:4.13E-15 ID:SGTC_352|Compound:k048-0007|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.63|P-value:1.18E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:-2.93|P-value:9.35E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:4.32|P-value:2.28E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.25|P-value:2.88E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.92|P-value:9.61E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.26|P-value:2.78E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.04|P-value:6.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.29|P-value:2.70E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.47|P-value:3.38E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:10.20|P-value:1.06E-27 ID:SGTC_842|Compound:0271-0008|FD-Score:3.90|P-value:1.76E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.93|P-value:8.61E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:7.61|P-value:3.53E-16 ID:SGTC_865|Compound:0488-0499|FD-Score:3.70|P-value:4.39E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.05|P-value:6.15E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.23|P-value:3.06E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.96|P-value:7.22E-8 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.03|P-value:6.58E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.07|P-value:5.56E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.11|P-value:4.90E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.08|P-value:5.50E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.89|P-value:1.10E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.39|P-value:5.30E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:27.80|P-value:1.13E-190 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.72|P-value:2.71E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.16|P-value:3.99E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.96|P-value:8.50E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.86|P-value:2.14E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.24|P-value:3.00E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.23|P-value:3.57E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.82|P-value:2.48E-5 ID:SGTC_1644|Compound:st010134|FD-Score:5.36|P-value:6.54E-9 ID:SGTC_1652|Compound:st011932|FD-Score:5.00|P-value:5.70E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-3.45|P-value:1.27E-4 ID:SGTC_1759|Compound:st043059|FD-Score:5.89|P-value:2.05E-10 ID:SGTC_1763|Compound:st044482|FD-Score:3.33|P-value:2.05E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-2.94|P-value:9.05E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.95|P-value:8.77E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.14|P-value:5.59E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.96|P-value:1.38E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.54|P-value:8.51E-5 ID:SGTC_2384|Compound:9036245|FD-Score:2.98|P-value:7.86E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.84|P-value:1.40E-7 ID:SGTC_2429|Compound:5902844|FD-Score:3.69|P-value:4.54E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.38|P-value:1.68E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.08|P-value:5.47E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:7.17E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:3.25|P-value:2.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:6.47E-30 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.48|P-value:1.03E-6 ID:SGTC_2915|Compound:7971052|FD-Score:3.15|P-value:4.09E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.71|P-value:4.24E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.00|P-value:2.92E-50 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.59|P-value:4.30E-16 ID:SGTC_3063|Compound:1327-0034|FD-Score:8.80|P-value:5.04E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:6.42|P-value:4.84E-12 ID:SGTC_3278|Compound:9139605|FD-Score:3.34|P-value:1.95E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.90|P-value:1.23E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.56E-51 ID:SGTC_64|Compound:000l-0018|FD-Score:17.30|P-value:7.26E-76 ID:SGTC_67|Compound:0335-0847|FD-Score:8.23|P-value:1.26E-18 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.33|P-value:2.06E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:14.00|P-value:3.01E-50 ID:SGTC_90|Compound:0870-0863|FD-Score:4.76|P-value:2.16E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:16.60|P-value:4.82E-70 ID:SGTC_107|Compound:0358-0022|FD-Score:6.89|P-value:1.34E-13 ID:SGTC_114|Compound:0364-0001|FD-Score:3.26|P-value:2.68E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.00|P-value:2.37E-43 ID:SGTC_142|Compound:0335-0849|FD-Score:13.00|P-value:1.02E-43 ID:SGTC_158|Compound:k038-0087|FD-Score:14.10|P-value:5.29E-51 ID:SGTC_200|Compound:k038-0079|FD-Score:3.52|P-value:9.35E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.67|P-value:9.19E-10 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.19|P-value:3.65E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:7.32|P-value:4.13E-15 ID:SGTC_352|Compound:k048-0007|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.63|P-value:1.18E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:-2.93|P-value:9.35E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:4.32|P-value:2.28E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.25|P-value:2.88E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.92|P-value:9.61E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.26|P-value:2.78E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.04|P-value:6.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.29|P-value:2.70E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.47|P-value:3.38E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:10.20|P-value:1.06E-27 ID:SGTC_842|Compound:0271-0008|FD-Score:3.90|P-value:1.76E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.93|P-value:8.61E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:7.61|P-value:3.53E-16 ID:SGTC_865|Compound:0488-0499|FD-Score:3.70|P-value:4.39E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.05|P-value:6.15E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.23|P-value:3.06E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:4.96|P-value:7.22E-8 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.03|P-value:6.58E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.98|P-value:1.22E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.07|P-value:5.56E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.11|P-value:4.90E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.08|P-value:5.50E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.89|P-value:1.10E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.39|P-value:5.30E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:27.80|P-value:1.13E-190 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.72|P-value:2.71E-7 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.16|P-value:3.99E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.96|P-value:8.50E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.86|P-value:2.14E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.24|P-value:3.00E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.23|P-value:3.57E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.82|P-value:2.48E-5 ID:SGTC_1644|Compound:st010134|FD-Score:5.36|P-value:6.54E-9 ID:SGTC_1652|Compound:st011932|FD-Score:5.00|P-value:5.70E-8 ID:SGTC_1754|Compound:st042065|FD-Score:-3.45|P-value:1.27E-4 ID:SGTC_1759|Compound:st043059|FD-Score:5.89|P-value:2.05E-10 ID:SGTC_1763|Compound:st044482|FD-Score:3.33|P-value:2.05E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-2.94|P-value:9.05E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.95|P-value:8.77E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.14|P-value:5.59E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.96|P-value:1.38E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.54|P-value:8.51E-5 ID:SGTC_2384|Compound:9036245|FD-Score:2.98|P-value:7.86E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.84|P-value:1.40E-7 ID:SGTC_2429|Compound:5902844|FD-Score:3.69|P-value:4.54E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.38|P-value:1.68E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.08|P-value:5.47E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:7.17E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:3.25|P-value:2.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:6.47E-30 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.48|P-value:1.03E-6 ID:SGTC_2915|Compound:7971052|FD-Score:3.15|P-value:4.09E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.71|P-value:4.24E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.00|P-value:2.92E-50 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.59|P-value:4.30E-16 ID:SGTC_3063|Compound:1327-0034|FD-Score:8.80|P-value:5.04E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:6.42|P-value:4.84E-12 ID:SGTC_3278|Compound:9139605|FD-Score:3.34|P-value:1.95E-4

Top fitness defect scores for YFR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 27.80 117.0 µM 1.13E-190 1 7.69E-170
2 SGTC_64 000l-0018 17.30 272.1 µM 7.26E-76 ubiquinone biosynthesis & proteasome 15 1.05E-67
3 SGTC_103 0844-0104 16.60 51.8 µM 4.82E-70 ERAD & cell cycle 7 1.58E-62
4 SGTC_58 0957-0393 14.20 9.0 µM 1.56E-51 cell wall 32 4.67E-46
5 SGTC_158 k038-0087 14.10 26.4 µM 5.29E-51 ubiquinone biosynthesis & proteasome 14 1.39E-45
6 SGTC_3059 1327-0034 14.00 3.0 µM 2.92E-50 7 6.33E-45
7 SGTC_86 0417-1630 14.00 471.9 µM 3.01E-50 ubiquinone biosynthesis & proteasome 20 6.51E-45
8 SGTC_142 0335-0849 13.00 62.7 µM 1.02E-43 ubiquinone biosynthesis & proteasome 21 4.22E-39
9 SGTC_137 0438-0332 13.00 85.4 µM 2.37E-43 ubiquinone biosynthesis & proteasome 19 8.94E-39
10 SGTC_2582 agaric acid 10.70 100.0 µM 6.47E-30 redox potentiating 54 8.12E-27
11 SGTC_794 k038-0031 10.20 316.0 µM 1.06E-27 ubiquinone biosynthesis & proteasome 15 7.57E-25
12 SGTC_3063 1327-0034 8.80 4.0 µM 5.04E-21 13 6.69E-19
13 SGTC_67 0335-0847 8.23 266.0 µM 1.26E-18 ubiquinone biosynthesis & proteasome 36 9.12E-17
14 SGTC_852 0418-0143 7.61 439.0 µM 3.53E-16 calcium & mitochondrial duress 13 1.38E-14
15 SGTC_3060 1327-0027 7.59 12.5 µM 4.30E-16 15 1.65E-14
16 SGTC_340 k038-0059 7.32 454.0 µM 4.13E-15 ubiquinone biosynthesis & proteasome 9 1.24E-13
17 SGTC_36 0335-0881 6.90 14.2 µM 1.23E-13 ubiquinone biosynthesis & proteasome 48 2.54E-12
18 SGTC_107 0358-0022 6.89 2.7 µM 1.34E-13 SWF1 & branched chain AA biosynthesis 10 2.75E-12
19 SGTC_3064 1327-0027 6.42 10.0 µM 4.84E-12 6 6.73E-11
20 SGTC_1759 st043059 5.89 70.0 µM 2.05E-10 amide catabolism 3 1.89E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.766 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.749 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.735 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.717 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.700 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.678 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.675 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.662 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.484 3.89E-196 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.481 2.90E-193 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.455 7.77E-171 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.454 4.04E-170 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.448 2.37E-165 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.446 2.11E-163 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.445 3.52E-162 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication