YFR008W / FAR7

Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR008W / FAR7

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.54|P-value:4.08E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.26|P-value:1.42E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.38|P-value:4.48E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.08|P-value:1.14E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:10.30|P-value:1.33E-24 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.67|P-value:1.50E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.16|P-value:9.58E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.28|P-value:6.41E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.39|P-value:1.64E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:3.73|P-value:1.24E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.14|P-value:2.28E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.85|P-value:7.60E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.54|P-value:2.51E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:4.71|P-value:1.79E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.28|P-value:6.23E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.96|P-value:2.26E-9 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.28|P-value:6.30E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.93|P-value:5.48E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.46|P-value:4.08E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.22|P-value:7.79E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.50|P-value:2.91E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.29|P-value:9.80E-8 ID:SGTC_779|Compound:1360-0071|FD-Score:3.44|P-value:3.57E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:2.25E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:8.43|P-value:5.60E-17 ID:SGTC_914|Compound:3820-6779|FD-Score:4.72|P-value:1.74E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:8.73E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.05|P-value:3.44E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.20|P-value:7.48E-24 ID:SGTC_1212|Compound:0520-0165|FD-Score:-6.17|P-value:6.31E-10 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.81|P-value:8.91E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.20|P-value:7.97E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.78|P-value:6.58E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.64|P-value:1.44E-8 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.29|P-value:6.13E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.20|P-value:8.46E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.15|P-value:9.91E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.24|P-value:6.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.30|P-value:1.18E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.43|P-value:3.63E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.17|P-value:2.05E-5 ID:SGTC_1737|Compound:st035557|FD-Score:4.05|P-value:3.40E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.15|P-value:2.25E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.46|P-value:3.42E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.75|P-value:1.46E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.32|P-value:5.54E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.16|P-value:2.21E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.69|P-value:8.04E-22 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.22|P-value:7.89E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.42|P-value:3.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.82|P-value:8.77E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.42|P-value:3.92E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.93|P-value:6.30E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.08|P-value:3.10E-5 ID:SGTC_3021|Compound:9087658|FD-Score:4.11|P-value:2.67E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.58|P-value:3.43E-6 ID:SGTC_3039|Compound:9090270|FD-Score:3.96|P-value:4.92E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.28|P-value:6.35E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-4.13|P-value:2.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.90|P-value:7.26E-7 ID:SGTC_3155|Compound:9099265|FD-Score:4.03|P-value:3.71E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.23|P-value:7.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.24|P-value:7.26E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.64|P-value:1.66E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.63|P-value:1.83E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.54|P-value:4.08E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.76|P-value:1.11E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.26|P-value:1.42E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.38|P-value:4.48E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:6.08|P-value:1.14E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:10.30|P-value:1.33E-24 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.67|P-value:1.50E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.16|P-value:9.58E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.28|P-value:6.41E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.39|P-value:1.64E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:3.73|P-value:1.24E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.14|P-value:2.28E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.85|P-value:7.60E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.54|P-value:2.51E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:4.71|P-value:1.79E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.28|P-value:6.23E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.96|P-value:2.26E-9 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.28|P-value:6.30E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.93|P-value:5.48E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.46|P-value:4.08E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.22|P-value:7.79E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.50|P-value:2.91E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.29|P-value:9.80E-8 ID:SGTC_779|Compound:1360-0071|FD-Score:3.44|P-value:3.57E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.67|P-value:2.25E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:8.43|P-value:5.60E-17 ID:SGTC_914|Compound:3820-6779|FD-Score:4.72|P-value:1.74E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:8.73E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.05|P-value:3.44E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.20|P-value:7.48E-24 ID:SGTC_1212|Compound:0520-0165|FD-Score:-6.17|P-value:6.31E-10 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.81|P-value:8.91E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.20|P-value:7.97E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.78|P-value:6.58E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.64|P-value:1.44E-8 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.29|P-value:6.13E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.20|P-value:8.46E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.15|P-value:9.91E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.24|P-value:6.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.30|P-value:1.18E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.43|P-value:3.63E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.17|P-value:2.05E-5 ID:SGTC_1737|Compound:st035557|FD-Score:4.05|P-value:3.40E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.15|P-value:2.25E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.46|P-value:3.42E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.75|P-value:1.46E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.32|P-value:5.54E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.16|P-value:2.21E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.69|P-value:8.04E-22 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.22|P-value:7.89E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.42|P-value:3.74E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.82|P-value:8.77E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.42|P-value:3.92E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.93|P-value:6.30E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.08|P-value:3.10E-5 ID:SGTC_3021|Compound:9087658|FD-Score:4.11|P-value:2.67E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.58|P-value:3.43E-6 ID:SGTC_3039|Compound:9090270|FD-Score:3.96|P-value:4.92E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.28|P-value:6.35E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-4.13|P-value:2.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.90|P-value:7.26E-7 ID:SGTC_3155|Compound:9099265|FD-Score:4.03|P-value:3.71E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.23|P-value:7.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.24|P-value:7.26E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.64|P-value:1.66E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.63|P-value:1.83E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.59|P-value:2.06E-4

Top fitness defect scores for YFR008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 10.30 51.8 µM 1.33E-24 ERAD & cell cycle 28 2.27E-25
2 SGTC_1161 k007-0610 10.20 110.0 µM 7.48E-24 ERAD & cell cycle 14 1.35E-24
3 SGTC_2582 agaric acid 9.69 100.0 µM 8.04E-22 redox potentiating 71 1.69E-22
4 SGTC_805 3852-0218 8.43 479.0 µM 5.60E-17 ERAD & cell cycle 8 1.71E-17
5 SGTC_158 k038-0087 6.39 26.4 µM 1.64E-10 ubiquinone biosynthesis & proteasome 62 8.19E-11
6 SGTC_86 0417-1630 6.08 471.9 µM 1.14E-9 ubiquinone biosynthesis & proteasome 88 6.04E-10
7 SGTC_1250 0485-0349 5.78 40.2 µM 6.58E-9 6 3.70E-9
8 SGTC_1353 1498-1206 5.64 8.1 µM 1.44E-8 mitochondrial response to ROS 20 8.31E-9
9 SGTC_568 1193-0097 5.46 7.5 µM 4.08E-8 ERAD & cell cycle 70 2.44E-8
10 SGTC_733 4069-0007 5.29 56.1 µM 9.80E-8 ERAD & cell cycle 49 6.02E-8
11 SGTC_2932 9016711 4.93 44.5 µM 6.30E-7 24 4.12E-7
12 SGTC_3152 9099253 4.90 49.5 µM 7.26E-7 NEO1-PIK1 81 4.76E-7
13 SGTC_914 3820-6779 4.72 408.0 µM 1.74E-6 10 1.18E-6
14 SGTC_415 dibenzyl ketone 4.71 100.0 µM 1.79E-6 7 1.21E-6
15 SGTC_794 k038-0031 4.67 316.0 µM 2.25E-6 ubiquinone biosynthesis & proteasome 89 1.53E-6
16 SGTC_3037 9091026 4.58 49.5 µM 3.43E-6 NEO1-PIK1 89 2.37E-6
17 SGTC_20 0481-0013 4.54 4.9 µM 4.08E-6 14 2.83E-6
18 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.30 61.9 µM 1.18E-5 9 8.49E-6
19 SGTC_64 000l-0018 4.26 272.1 µM 1.42E-5 ubiquinone biosynthesis & proteasome 136 1.03E-5
20 SGTC_1727 st034309 4.17 9.9 µM 2.05E-5 29 1.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.399 1.34E-128 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.356 5.63E-101 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.351 5.59E-98 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.348 4.48E-96 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.346 6.61E-95 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.338 1.58E-90 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.337 5.52E-90 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.334 2.31E-88 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.325 4.27E-83 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.320 1.84E-80 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.316 1.64E-78 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.309 5.47E-75 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.306 2.10E-73 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.292 9.10E-67 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.288 4.62E-65 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins