YFR012W-A_p

Putative protein of unknown function; identified by homology

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR012W-A / YFR012W-A

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:2.75|P-value:7.03E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.27|P-value:7.31E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.50|P-value:2.37E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.10|P-value:9.74E-7 ID:SGTC_441|Compound:propafenone|FD-Score:-2.87|P-value:4.38E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-5.68|P-value:2.28E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.87|P-value:4.40E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.43|P-value:1.33E-7 ID:SGTC_458|Compound:nppb|FD-Score:5.56|P-value:5.39E-11 ID:SGTC_622|Compound:1348-1566|FD-Score:2.67|P-value:9.45E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:2.79|P-value:5.82E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-2.95|P-value:3.17E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.89|P-value:3.14E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:3.38|P-value:4.34E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.91|P-value:3.58E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.77|P-value:6.62E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.92|P-value:3.38E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.88|P-value:4.06E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:2.83|P-value:5.01E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.29|P-value:6.73E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.87|P-value:3.38E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.12|P-value:1.42E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.55|P-value:1.83E-5 ID:SGTC_1678|Compound:st019265|FD-Score:2.92|P-value:3.39E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.10|P-value:1.61E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.69|P-value:8.79E-4 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:1.20E-6 ID:SGTC_2036|Compound:5160441|FD-Score:2.68|P-value:9.07E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.09|P-value:1.62E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.66|P-value:9.76E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.32|P-value:2.62E-7 ID:SGTC_2347|Compound:9049783|FD-Score:4.09|P-value:1.00E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.19|P-value:1.08E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.49|P-value:2.52E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.80|P-value:5.63E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.33|P-value:2.46E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.13|P-value:1.40E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.54|P-value:2.04E-5 ID:SGTC_2691|Compound:st077356|FD-Score:6.47|P-value:2.88E-14 ID:SGTC_2700|Compound:st077718|FD-Score:4.18|P-value:6.10E-7 ID:SGTC_2816|Compound:7982706|FD-Score:7.15|P-value:4.94E-17 ID:SGTC_2820|Compound:7989630|FD-Score:4.78|P-value:1.43E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.04|P-value:1.31E-6 ID:SGTC_2846|Compound:9008642|FD-Score:2.93|P-value:3.31E-4 ID:SGTC_2947|Compound:9072639|FD-Score:2.71|P-value:8.19E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.05|P-value:2.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.33|P-value:5.71E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.17|P-value:1.16E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.78|P-value:5.59E-6 ID:SGTC_3117|Compound:9124945|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.95|P-value:2.37E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.84|P-value:4.08E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-2.71|P-value:8.54E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-4.48|P-value:9.98E-8 ID:SGTC_3232|Compound:9132874|FD-Score:-2.79|P-value:6.08E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.56|P-value:1.85E-5 ID:SGTC_3325|Compound:9138760|FD-Score:4.40|P-value:1.59E-7 ID:SGTC_3330|Compound:9141424|FD-Score:3.11|P-value:1.51E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:2.75|P-value:7.03E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.27|P-value:7.31E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.50|P-value:2.37E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.10|P-value:9.74E-7 ID:SGTC_441|Compound:propafenone|FD-Score:-2.87|P-value:4.38E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-5.68|P-value:2.28E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.87|P-value:4.40E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.43|P-value:1.33E-7 ID:SGTC_458|Compound:nppb|FD-Score:5.56|P-value:5.39E-11 ID:SGTC_622|Compound:1348-1566|FD-Score:2.67|P-value:9.45E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:2.79|P-value:5.82E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-2.95|P-value:3.17E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.89|P-value:3.14E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:3.38|P-value:4.34E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.91|P-value:3.58E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.77|P-value:6.62E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.92|P-value:3.38E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.88|P-value:4.06E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:2.83|P-value:5.01E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.29|P-value:6.73E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.87|P-value:3.38E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.12|P-value:1.42E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.55|P-value:1.83E-5 ID:SGTC_1678|Compound:st019265|FD-Score:2.92|P-value:3.39E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.10|P-value:1.61E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.69|P-value:8.79E-4 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:1.20E-6 ID:SGTC_2036|Compound:5160441|FD-Score:2.68|P-value:9.07E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.09|P-value:1.62E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.66|P-value:9.76E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.32|P-value:2.62E-7 ID:SGTC_2347|Compound:9049783|FD-Score:4.09|P-value:1.00E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.19|P-value:1.08E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.49|P-value:2.52E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.80|P-value:5.63E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.33|P-value:2.46E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.13|P-value:1.40E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.54|P-value:2.04E-5 ID:SGTC_2691|Compound:st077356|FD-Score:6.47|P-value:2.88E-14 ID:SGTC_2700|Compound:st077718|FD-Score:4.18|P-value:6.10E-7 ID:SGTC_2816|Compound:7982706|FD-Score:7.15|P-value:4.94E-17 ID:SGTC_2820|Compound:7989630|FD-Score:4.78|P-value:1.43E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.04|P-value:1.31E-6 ID:SGTC_2846|Compound:9008642|FD-Score:2.93|P-value:3.31E-4 ID:SGTC_2947|Compound:9072639|FD-Score:2.71|P-value:8.19E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.05|P-value:2.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.33|P-value:5.71E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.17|P-value:1.16E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.78|P-value:5.59E-6 ID:SGTC_3117|Compound:9124945|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.95|P-value:2.37E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.84|P-value:4.08E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-2.71|P-value:8.54E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-4.48|P-value:9.98E-8 ID:SGTC_3232|Compound:9132874|FD-Score:-2.79|P-value:6.08E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.56|P-value:1.85E-5 ID:SGTC_3325|Compound:9138760|FD-Score:4.40|P-value:1.59E-7 ID:SGTC_3330|Compound:9141424|FD-Score:3.11|P-value:1.51E-4

Top fitness defect scores for YFR012W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2816 7982706 7.15 58.4 µM 4.94E-17 azole & statin 9 4.26E-13
2 SGTC_2691 st077356 6.47 60.2 µM 2.88E-14 2 4.92E-11
3 SGTC_458 nppb 5.56 133.0 µM 5.39E-11 3 1.36E-8
4 SGTC_2820 7989630 4.78 71.4 µM 1.43E-8 ERG2 9 8.88E-7
5 SGTC_455 paf C-16 4.43 10.0 µM 1.33E-7 22 4.71E-6
6 SGTC_3325 9138760 4.40 55.2 µM 1.59E-7 Golgi 17 5.39E-6
7 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.33 100.0 µM 2.46E-7 13 7.47E-6
8 SGTC_2236 dapsone 4.32 200.0 µM 2.62E-7 4 7.84E-6
9 SGTC_2700 st077718 4.18 96.8 µM 6.10E-7 11 1.48E-5
10 SGTC_391 gliotoxin 4.10 8.3 µM 9.74E-7 54 2.10E-5
11 SGTC_2347 9049783 4.09 174.8 µM 1.00E-6 24 2.15E-5
12 SGTC_1884 5633444 4.06 25.0 µM 1.20E-6 redox potentiating 49 2.45E-5
13 SGTC_2827 7993847 4.04 71.4 µM 1.31E-6 21 2.63E-5
14 SGTC_770 0389-1121 3.89 67.2 µM 3.14E-6 RPP1 & pyrimidine depletion 30 5.06E-5
15 SGTC_1522 st012842 3.87 45.6 µM 3.38E-6 RNA pol III & RNase P/MRP 28 5.34E-5
16 SGTC_3219 9131112 3.84 49.5 µM 4.08E-6 Golgi 37 6.17E-5
17 SGTC_3106 9121286 3.78 49.5 µM 5.59E-6 17 7.81E-5
18 SGTC_1633 st005664 3.55 67.9 µM 1.83E-5 47 1.91E-4
19 SGTC_364 0083-0097 3.50 67.7 µM 2.37E-5 42 2.32E-4
20 SGTC_2606 farnesol 3.49 9.8 µM 2.52E-5 34 2.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.88E-12 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.112 7.58E-11 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.108 2.93E-10 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.104 1.74E-9 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.103 1.86E-9 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.099 9.44E-9 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.099 9.67E-9 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.096 2.43E-8 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.095 3.11E-8 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.092 1.06E-7 YGR073C_d YGR073C_d het Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
0.089 2.56E-7 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.088 3.37E-7 YMR188C MRPS17 hom Mitochondrial ribosomal protein of the small subunit
0.088 3.81E-7 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.085 7.54E-7 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.085 8.22E-7 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)