HIPHOP chemogenomics database

YFR012W-A_p

Putative protein of unknown function; identified by homology

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR012W-A / YFR012W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YFR012W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2816	7982706	7.15	58.4 µM	4.94E-17	azole & statin	9	4.26E-13
2	SGTC_2691	st077356	6.47	60.2 µM	2.88E-14		2	4.92E-11
3	SGTC_458	nppb	5.56	133.0 µM	5.39E-11		3	1.36E-8
4	SGTC_2820	7989630	4.78	71.4 µM	1.43E-8	ERG2	9	8.88E-7
5	SGTC_455	paf C-16	4.43	10.0 µM	1.33E-7		22	4.71E-6
6	SGTC_3325	9138760	4.40	55.2 µM	1.59E-7	Golgi	17	5.39E-6
7	SGTC_2632	3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone	4.33	100.0 µM	2.46E-7		13	7.47E-6
8	SGTC_2236	dapsone	4.32	200.0 µM	2.62E-7		4	7.84E-6
9	SGTC_2700	st077718	4.18	96.8 µM	6.10E-7		11	1.48E-5
10	SGTC_391	gliotoxin	4.10	8.3 µM	9.74E-7		54	2.10E-5
11	SGTC_2347	9049783	4.09	174.8 µM	1.00E-6		24	2.15E-5
12	SGTC_1884	5633444	4.06	25.0 µM	1.20E-6	redox potentiating	49	2.45E-5
13	SGTC_2827	7993847	4.04	71.4 µM	1.31E-6		21	2.63E-5
14	SGTC_770	0389-1121	3.89	67.2 µM	3.14E-6	RPP1 & pyrimidine depletion	30	5.06E-5
15	SGTC_1522	st012842	3.87	45.6 µM	3.38E-6	RNA pol III & RNase P/MRP	28	5.34E-5
16	SGTC_3219	9131112	3.84	49.5 µM	4.08E-6	Golgi	37	6.17E-5
17	SGTC_3106	9121286	3.78	49.5 µM	5.59E-6		17	7.81E-5
18	SGTC_1633	st005664	3.55	67.9 µM	1.83E-5		47	1.91E-4
19	SGTC_364	0083-0097	3.50	67.7 µM	2.37E-5		42	2.32E-4
20	SGTC_2606	farnesol	3.49	9.8 µM	2.52E-5		34	2.43E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.118	7.88E-12	YBR131W	CCZ1	hom	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.112	7.58E-11	YDR371W_p	CTS2_p	hom	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.108	2.93E-10	YCR012W	PGK1	het	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.104	1.74E-9	YLR099C	ICT1	hom	Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.103	1.86E-9	YKR031C	SPO14	hom	Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.099	9.44E-9	YDR018C_p	YDR018C_p	hom	Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.099	9.67E-9	YOR284W	HUA2	hom	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.096	2.43E-8	YKR002W	PAP1	het	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.095	3.11E-8	YGR091W	PRP31	het	Splicing factor, component of the U4/U6-U5 snRNP complex
0.092	1.06E-7	YGR073C_d	YGR073C_d	het	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
0.089	2.56E-7	YLR078C	BOS1	het	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.088	3.37E-7	YMR188C	MRPS17	hom	Mitochondrial ribosomal protein of the small subunit
0.088	3.81E-7	YMR133W	REC114	hom	Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.085	7.54E-7	YJL212C	OPT1	hom	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.085	8.22E-7	YNL046W_p	YNL046W_p	hom	Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)