YFR013W / IOC3

Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR013W / IOC3

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:4.21|P-value:4.60E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.38|P-value:9.04E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.29|P-value:3.75E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:3.67|P-value:3.44E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.76|P-value:2.49E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.06|P-value:8.11E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.39|P-value:8.74E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.53|P-value:5.39E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:5.95|P-value:1.26E-8 ID:SGTC_573|Compound:3702-0553|FD-Score:3.77|P-value:2.40E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.45|P-value:1.68E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.19|P-value:8.27E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.16|P-value:9.03E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-4.27|P-value:1.49E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.61|P-value:8.69E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.39|P-value:2.23E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.52|P-value:5.60E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.86|P-value:7.51E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.47|P-value:6.60E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.01|P-value:1.44E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.51|P-value:1.26E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.38|P-value:9.10E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.48|P-value:6.57E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.03|P-value:9.07E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.21|P-value:4.62E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-5.57|P-value:3.01E-8 ID:SGTC_2003|Compound:4023581|FD-Score:4.25|P-value:3.80E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.93|P-value:1.34E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.77|P-value:2.41E-4 ID:SGTC_2116|Compound:5511452|FD-Score:5.07|P-value:1.11E-6 ID:SGTC_2123|Compound:5259487|FD-Score:5.95|P-value:1.26E-8 ID:SGTC_2168|Compound:5727979|FD-Score:3.38|P-value:8.93E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.36|P-value:2.44E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.96|P-value:1.81E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.24|P-value:7.01E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.70|P-value:3.08E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.85|P-value:1.80E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.43|P-value:3.69E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.33|P-value:2.85E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.89|P-value:1.68E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.45|P-value:7.19E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.43|P-value:1.89E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.97|P-value:1.15E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.46|P-value:6.57E-6 ID:SGTC_2914|Compound:7968218|FD-Score:4.05|P-value:8.37E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.89|P-value:6.75E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.42|P-value:1.98E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.01|P-value:9.70E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.45|P-value:1.70E-5 ID:SGTC_3084|Compound:9116877|FD-Score:-3.25|P-value:6.86E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.19|P-value:4.83E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.36|P-value:4.73E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.14|P-value:5.93E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.49|P-value:6.30E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:4.21|P-value:4.60E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.38|P-value:9.04E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.29|P-value:3.75E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:3.67|P-value:3.44E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.76|P-value:2.49E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.06|P-value:8.11E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.39|P-value:8.74E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.53|P-value:5.39E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:5.95|P-value:1.26E-8 ID:SGTC_573|Compound:3702-0553|FD-Score:3.77|P-value:2.40E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.45|P-value:1.68E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.19|P-value:8.27E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.16|P-value:9.03E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-4.27|P-value:1.49E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.61|P-value:8.69E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.39|P-value:2.23E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.52|P-value:5.60E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.86|P-value:7.51E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.80|P-value:2.12E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.47|P-value:6.60E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.01|P-value:1.44E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.51|P-value:1.26E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.38|P-value:9.10E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.48|P-value:6.57E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.03|P-value:9.07E-5 ID:SGTC_1956|Compound:st077085|FD-Score:4.21|P-value:4.62E-5 ID:SGTC_1970|Compound:st070122|FD-Score:-5.57|P-value:3.01E-8 ID:SGTC_2003|Compound:4023581|FD-Score:4.25|P-value:3.80E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.93|P-value:1.34E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.77|P-value:2.41E-4 ID:SGTC_2116|Compound:5511452|FD-Score:5.07|P-value:1.11E-6 ID:SGTC_2123|Compound:5259487|FD-Score:5.95|P-value:1.26E-8 ID:SGTC_2168|Compound:5727979|FD-Score:3.38|P-value:8.93E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.36|P-value:2.44E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.96|P-value:1.81E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.24|P-value:7.01E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.70|P-value:3.08E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.85|P-value:1.80E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.43|P-value:3.69E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.33|P-value:2.85E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.89|P-value:1.68E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.45|P-value:7.19E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.43|P-value:1.89E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.97|P-value:1.15E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.46|P-value:6.57E-6 ID:SGTC_2914|Compound:7968218|FD-Score:4.05|P-value:8.37E-5 ID:SGTC_2963|Compound:9082507|FD-Score:-3.89|P-value:6.75E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.42|P-value:1.98E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.01|P-value:9.70E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.45|P-value:1.70E-5 ID:SGTC_3084|Compound:9116877|FD-Score:-3.25|P-value:6.86E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.19|P-value:4.83E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.36|P-value:4.73E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.14|P-value:5.93E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.49|P-value:6.30E-4

Top fitness defect scores for YFR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2123 5259487 5.95 200.0 µM 1.26E-8 1 1.36E-9
2 SGTC_540 1187-0821 5.95 17.3 µM 1.26E-8 2 1.36E-9
3 SGTC_2749 bexarotene 5.89 57.4 µM 1.68E-8 5 1.87E-9
4 SGTC_1538 2',3',6-trimethoxyflavanone 5.51 63.6 µM 1.26E-7 2 1.78E-8
5 SGTC_322 k048-0136 5.29 19.3 µM 3.75E-7 RSC & ERG11 5 5.99E-8
6 SGTC_2116 5511452 5.07 16.9 µM 1.11E-6 4 2.02E-7
7 SGTC_1532 4',5'-dihydroxyflavone 5.01 78.7 µM 1.44E-6 Golgi 13 2.69E-7
8 SGTC_2293 7624732 4.96 200.0 µM 1.81E-6 7 3.47E-7
9 SGTC_1051 3253-3903 4.61 78.0 µM 8.69E-6 9 2.01E-6
10 SGTC_169 k015-0017 4.57 16.0 µM 1.03E-5 14 2.43E-6
11 SGTC_664 1222-0054 4.45 14.9 µM 1.68E-5 sphingolipid biosynthesis & PDR1 29 4.21E-6
12 SGTC_2977 9011197 4.45 71.4 µM 1.70E-5 11 4.24E-6
13 SGTC_2785 7756463 4.43 72.7 µM 1.89E-5 17 4.79E-6
14 SGTC_2964 9083345 4.42 53.4 µM 1.98E-5 13 5.04E-6
15 SGTC_1061 3448-9325 4.39 110.0 µM 2.23E-5 15 5.74E-6
16 SGTC_2274 7947094 4.36 46.1 µM 2.44E-5 20 6.38E-6
17 SGTC_2730 imipramine 4.33 71.3 µM 2.85E-5 12 7.58E-6
18 SGTC_2003 4023581 4.25 200.0 µM 3.80E-5 cell wall signaling 28 1.05E-5
19 SGTC_85 0868-0259 4.21 160.1 µM 4.60E-5 60S ribosome export 7 1.29E-5
20 SGTC_1956 st077085 4.21 54.0 µM 4.62E-5 14 1.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 6.15E-7 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.075 1.28E-5 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.075 1.32E-5 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.072 2.89E-5 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.071 3.53E-5 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication
0.069 6.86E-5 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.065 1.56E-4 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.064 2.16E-4 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.062 3.05E-4 YOL131W_p YOL131W_p hom Putative protein of unknown function
0.062 3.31E-4 YKR025W RPC37 het RNA polymerase III subunit C37
0.061 4.52E-4 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.060 5.28E-4 YCR059C YIH1 hom Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT
0.059 6.23E-4 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.058 7.41E-4 YEL033W_p MTC7_p hom Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
0.058 7.70E-4 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication