HIPHOP chemogenomics database

YFR015C / GSY1

Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR015C / GSY1

Click on Significant Values for Screen Details

Top fitness defect scores for YFR015C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_456	gingerol	6.89	170.0 µM	4.38E-15		1	2.73E-12
2	SGTC_2930	9013230	5.53	14.9 µM	2.26E-10	heme biosynthesis & mitochondrial translocase	11	1.57E-8
3	SGTC_305	1682-2595	5.18	20.8 µM	2.58E-9	RNA processing & uracil transport	9	1.09E-7
4	SGTC_2583	asiatic acid	5.15	100.0 µM	3.23E-9		20	1.31E-7
5	SGTC_446	go6976	4.76	132.0 µM	3.96E-8		8	9.69E-7
6	SGTC_1412	3909-8563	3.99	178.0 µM	3.27E-6		6	3.29E-5
7	SGTC_2013	4024628	3.95	200.0 µM	4.08E-6		41	3.93E-5
8	SGTC_2584	androsterone	3.86	48.7 µM	6.42E-6	cell wall	138	5.65E-5
9	SGTC_2014	4013930	3.76	200.0 µM	1.07E-5		39	8.49E-5
10	SGTC_1753	st043925	3.43	64.0 µM	5.25E-5		18	3.04E-4
11	SGTC_2648	atorvastatin	3.35	78.7 µM	7.41E-5	azole & statin	33	4.00E-4
12	SGTC_479	n-linoleoylglycine	3.26	10.0 µM	1.11E-4		21	5.52E-4
13	SGTC_2634	4'-methoxyflavone	3.03	100.0 µM	3.00E-4		78	0.00123
14	SGTC_1830	st055982	3.01	50.3 µM	3.30E-4		67	0.00133
15	SGTC_267	4-Nitroquinoline-1-oxide (4-NQO)	2.99	44.4 nM	3.51E-4	DNA damage response	67	0.00139
16	SGTC_1211	1056-0033	2.98	32.3 µM	3.71E-4		34	0.00146
17	SGTC_1084	voriconazole	2.96	435.0 nM	3.91E-4	azole & statin	68	0.00152
18	SGTC_898	1000-0849	2.90	28.3 µM	4.96E-4		38	0.00184
19	SGTC_2935	9038016	2.90	30.0 µM	5.12E-4		69	0.00189
20	SGTC_281	1672-3440	2.87	14.9 µM	5.80E-4	Golgi	37	0.00208

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.188	5.00E-28	YDR528W	HLR1	hom	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.128	9.46E-14	YML086C	ALO1	hom	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.128	1.24E-13	YIL042C	PKP1	hom	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.128	1.22E-13	YDR497C	ITR1	hom	Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.123	7.91E-13	YDR206W	EBS1	hom	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.120	3.38E-12	YOR152C_p	YOR152C_p	hom	Putative protein of unknown function; YOR152C is not an essential gene
0.114	4.06E-11	YFL003C	MSH4	hom	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.112	8.76E-11	YLR413W_p	YLR413W_p	hom	Putative protein of unknown function; YLR413W is not an essential gene
0.111	1.28E-10	YDR133C_d	YDR133C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.109	2.41E-10	YGR149W_p	YGR149W_p	hom	Putative protein of unknown function; predicted to be an integal membrane protein
0.108	3.47E-10	YLR267W_p	BOP2_p	hom	Protein of unknown function
0.107	5.67E-10	YBR134W_d	YBR134W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105	1.02E-9	YDR239C	YDR239C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.104	1.67E-9	YJR106W	ECM27	hom	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.103	2.18E-9	YKL184W	SPE1	hom	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation