Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFR015C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.188 | 5.00E-28 | YDR528W | HLR1 | hom | Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; HLR1 has a paralog, LRE1, that arose from the whole genome duplication |
0.128 | 9.46E-14 | YML086C | ALO1 | hom | D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress |
0.128 | 1.24E-13 | YIL042C | PKP1 | hom | Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p |
0.128 | 1.22E-13 | YDR497C | ITR1 | hom | Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress |
0.123 | 7.91E-13 | YDR206W | EBS1 | hom | Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors |
0.120 | 3.38E-12 | YOR152C_p | YOR152C_p | hom | Putative protein of unknown function; YOR152C is not an essential gene |
0.114 | 4.06E-11 | YFL003C | MSH4 | hom | Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein |
0.112 | 8.76E-11 | YLR413W_p | YLR413W_p | hom | Putative protein of unknown function; YLR413W is not an essential gene |
0.111 | 1.28E-10 | YDR133C_d | YDR133C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C |
0.109 | 2.41E-10 | YGR149W_p | YGR149W_p | hom | Putative protein of unknown function; predicted to be an integal membrane protein |
0.108 | 3.47E-10 | YLR267W_p | BOP2_p | hom | Protein of unknown function |
0.107 | 5.67E-10 | YBR134W_d | YBR134W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.105 | 1.02E-9 | YDR239C | YDR239C | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments |
0.104 | 1.67E-9 | YJR106W | ECM27 | hom | Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p |
0.103 | 2.18E-9 | YKL184W | SPE1 | hom | Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation |