YFR015C / GSY1

Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR015C / GSY1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-2.86|P-value:7.89E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.03|P-value:3.99E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.62|P-value:2.99E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.99|P-value:3.51E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:2.87|P-value:5.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:5.18|P-value:2.58E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.64|P-value:2.76E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.76|P-value:3.96E-8 ID:SGTC_456|Compound:gingerol|FD-Score:6.89|P-value:4.38E-15 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.38|P-value:9.01E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:2.78|P-value:8.15E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.34|P-value:1.08E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.90|P-value:4.96E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.96|P-value:3.91E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.84|P-value:8.71E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.98|P-value:3.71E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.99|P-value:3.27E-6 ID:SGTC_1703|Compound:st026983|FD-Score:2.86|P-value:5.97E-4 ID:SGTC_1707|Compound:st032323|FD-Score:2.82|P-value:6.93E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-2.87|P-value:7.51E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.43|P-value:5.25E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.01|P-value:3.30E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.95|P-value:4.08E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.76|P-value:1.07E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:1.42E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.15|P-value:3.23E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:3.86|P-value:6.42E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.90|P-value:6.85E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.03|P-value:3.00E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:7.41E-5 ID:SGTC_2844|Compound:9010103|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_2930|Compound:9013230|FD-Score:5.53|P-value:2.26E-10 ID:SGTC_2935|Compound:9038016|FD-Score:2.90|P-value:5.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.71|P-value:8.57E-8 ID:SGTC_2937|Compound:9044753|FD-Score:-3.07|P-value:3.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.84|P-value:8.44E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.86|P-value:7.89E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.03|P-value:3.99E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.62|P-value:2.99E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.99|P-value:3.51E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:2.87|P-value:5.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:5.18|P-value:2.58E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.64|P-value:2.76E-5 ID:SGTC_446|Compound:go6976|FD-Score:4.76|P-value:3.96E-8 ID:SGTC_456|Compound:gingerol|FD-Score:6.89|P-value:4.38E-15 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.38|P-value:9.01E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:2.78|P-value:8.15E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.34|P-value:1.08E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.90|P-value:4.96E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.96|P-value:3.91E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.84|P-value:8.71E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.98|P-value:3.71E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.99|P-value:3.27E-6 ID:SGTC_1703|Compound:st026983|FD-Score:2.86|P-value:5.97E-4 ID:SGTC_1707|Compound:st032323|FD-Score:2.82|P-value:6.93E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-2.87|P-value:7.51E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.43|P-value:5.25E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.01|P-value:3.30E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.95|P-value:4.08E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.76|P-value:1.07E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:1.42E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.15|P-value:3.23E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:3.86|P-value:6.42E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.90|P-value:6.85E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.03|P-value:3.00E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:7.41E-5 ID:SGTC_2844|Compound:9010103|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_2930|Compound:9013230|FD-Score:5.53|P-value:2.26E-10 ID:SGTC_2935|Compound:9038016|FD-Score:2.90|P-value:5.12E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.71|P-value:8.57E-8 ID:SGTC_2937|Compound:9044753|FD-Score:-3.07|P-value:3.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.84|P-value:8.44E-4

Top fitness defect scores for YFR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_456 gingerol 6.89 170.0 µM 4.38E-15 1 2.73E-12
2 SGTC_2930 9013230 5.53 14.9 µM 2.26E-10 heme biosynthesis & mitochondrial translocase 11 1.57E-8
3 SGTC_305 1682-2595 5.18 20.8 µM 2.58E-9 RNA processing & uracil transport 9 1.09E-7
4 SGTC_2583 asiatic acid 5.15 100.0 µM 3.23E-9 20 1.31E-7
5 SGTC_446 go6976 4.76 132.0 µM 3.96E-8 8 9.69E-7
6 SGTC_1412 3909-8563 3.99 178.0 µM 3.27E-6 6 3.29E-5
7 SGTC_2013 4024628 3.95 200.0 µM 4.08E-6 41 3.93E-5
8 SGTC_2584 androsterone 3.86 48.7 µM 6.42E-6 cell wall 138 5.65E-5
9 SGTC_2014 4013930 3.76 200.0 µM 1.07E-5 39 8.49E-5
10 SGTC_1753 st043925 3.43 64.0 µM 5.25E-5 18 3.04E-4
11 SGTC_2648 atorvastatin 3.35 78.7 µM 7.41E-5 azole & statin 33 4.00E-4
12 SGTC_479 n-linoleoylglycine 3.26 10.0 µM 1.11E-4 21 5.52E-4
13 SGTC_2634 4'-methoxyflavone 3.03 100.0 µM 3.00E-4 78 0.00123
14 SGTC_1830 st055982 3.01 50.3 µM 3.30E-4 67 0.00133
15 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 2.99 44.4 nM 3.51E-4 DNA damage response 67 0.00139
16 SGTC_1211 1056-0033 2.98 32.3 µM 3.71E-4 34 0.00146
17 SGTC_1084 voriconazole 2.96 435.0 nM 3.91E-4 azole & statin 68 0.00152
18 SGTC_898 1000-0849 2.90 28.3 µM 4.96E-4 38 0.00184
19 SGTC_2935 9038016 2.90 30.0 µM 5.12E-4 69 0.00189
20 SGTC_281 1672-3440 2.87 14.9 µM 5.80E-4 Golgi 37 0.00208

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.00E-28 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.128 9.46E-14 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.128 1.24E-13 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.128 1.22E-13 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.123 7.91E-13 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.120 3.38E-12 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.114 4.06E-11 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.112 8.76E-11 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene
0.111 1.28E-10 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.109 2.41E-10 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.108 3.47E-10 YLR267W_p BOP2_p hom Protein of unknown function
0.107 5.67E-10 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.02E-9 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.104 1.67E-9 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.103 2.18E-9 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation