YFR019W / FAB1

1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR019W / FAB1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.88|P-value:1.36E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.35|P-value:6.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.01|P-value:7.50E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:5.40|P-value:1.04E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:8.42|P-value:2.48E-16 ID:SGTC_118|Compound:0083-0097|FD-Score:3.94|P-value:7.91E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:6.05|P-value:2.90E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:3.94|P-value:7.82E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.13|P-value:3.60E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.64|P-value:2.40E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.99|P-value:7.98E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.55|P-value:1.42E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.93|P-value:1.09E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:6.02|P-value:3.53E-9 ID:SGTC_355|Compound:1311-2252|FD-Score:3.98|P-value:6.68E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.03|P-value:5.44E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.50|P-value:3.25E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.94|P-value:1.00E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:5.55|P-value:4.76E-8 ID:SGTC_596|Compound:1155-0152|FD-Score:4.15|P-value:3.40E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.65|P-value:2.34E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.54|P-value:3.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.67|P-value:2.12E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.26|P-value:8.83E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.38|P-value:5.88E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-3.42|P-value:4.33E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.56|P-value:6.00E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.07|P-value:4.74E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.29|P-value:8.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.42|P-value:5.63E-20 ID:SGTC_1909|Compound:st060837|FD-Score:3.57|P-value:3.07E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.46|P-value:4.55E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.28|P-value:8.45E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.55|P-value:2.75E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.93|P-value:8.01E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.36|P-value:6.90E-13 ID:SGTC_2276|Compound:7947513|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.14|P-value:3.59E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.21|P-value:2.62E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:11.80|P-value:1.53E-30 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.05|P-value:5.02E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.45|P-value:4.68E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:1.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.46|P-value:7.69E-8 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.14|P-value:3.53E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.27|P-value:1.53E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.10|P-value:4.17E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.80|P-value:1.08E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.75|P-value:2.54E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.01|P-value:5.95E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.45|P-value:3.86E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.37|P-value:5.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.31|P-value:7.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.65|P-value:1.89E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.88|P-value:1.36E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.35|P-value:6.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.01|P-value:7.50E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:5.40|P-value:1.04E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:8.42|P-value:2.48E-16 ID:SGTC_118|Compound:0083-0097|FD-Score:3.94|P-value:7.91E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:6.05|P-value:2.90E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:3.94|P-value:7.82E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.13|P-value:3.60E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.64|P-value:2.40E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.99|P-value:7.98E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.55|P-value:1.42E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.93|P-value:1.09E-14 ID:SGTC_310|Compound:1273-0058|FD-Score:6.02|P-value:3.53E-9 ID:SGTC_355|Compound:1311-2252|FD-Score:3.98|P-value:6.68E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.03|P-value:5.44E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.50|P-value:3.25E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.94|P-value:1.00E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:5.55|P-value:4.76E-8 ID:SGTC_596|Compound:1155-0152|FD-Score:4.15|P-value:3.40E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.65|P-value:2.34E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.54|P-value:3.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.67|P-value:2.12E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.26|P-value:8.83E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.38|P-value:5.88E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.66|P-value:2.26E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-3.42|P-value:4.33E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.56|P-value:6.00E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.07|P-value:4.74E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.29|P-value:8.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.42|P-value:5.63E-20 ID:SGTC_1909|Compound:st060837|FD-Score:3.57|P-value:3.07E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.46|P-value:4.55E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.28|P-value:8.45E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.55|P-value:2.75E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.93|P-value:8.01E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.36|P-value:6.90E-13 ID:SGTC_2276|Compound:7947513|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.14|P-value:3.59E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.21|P-value:2.62E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:11.80|P-value:1.53E-30 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.05|P-value:5.02E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.45|P-value:4.68E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:1.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.46|P-value:7.69E-8 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.14|P-value:3.53E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.27|P-value:1.53E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.10|P-value:4.17E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.80|P-value:1.08E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.75|P-value:2.54E-6 ID:SGTC_2845|Compound:9003024|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.01|P-value:5.95E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.45|P-value:3.86E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.37|P-value:5.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.31|P-value:7.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.65|P-value:1.89E-4

Top fitness defect scores for YFR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2533 agelasine 11.80 13.7 µM 1.53E-30 ERG2 3 1.09E-32
2 SGTC_1844 rapamycin 9.42 4.0 nM 5.63E-20 43 2.33E-21
3 SGTC_70 0141-0289 8.42 43.3 µM 2.48E-16 mitochondrial stress 35 1.88E-17
4 SGTC_275 trichlorophene 7.93 5.7 µM 1.09E-14 mitochondrial stress 77 1.08E-15
5 SGTC_2250 alverine citrate 7.36 130.0 µM 6.90E-13 29 9.32E-14
6 SGTC_58 0957-0393 7.01 9.0 µM 7.50E-12 cell wall 163 1.20E-12
7 SGTC_236 1509-0011 6.55 5.3 µM 1.42E-10 273 2.83E-11
8 SGTC_119 0121-0043 6.05 24.8 µM 2.90E-9 mitochondrial stress 28 7.18E-10
9 SGTC_310 1273-0058 6.02 1.1 µM 3.53E-9 mitochondrial stress 144 8.87E-10
10 SGTC_520 3584-0023 5.55 682.0 µM 4.76E-8 4 1.45E-8
11 SGTC_2679 rapamycin 5.46 1.0 nM 7.69E-8 89 2.42E-8
12 SGTC_63 0099-0242 5.40 26.7 µM 1.04E-7 mitochondrial stress 40 3.36E-8
13 SGTC_173 1273-0061 4.99 2.7 µM 7.98E-7 mitochondrial stress 149 2.99E-7
14 SGTC_467 ro 31-8220 4.94 72.8 µM 1.00E-6 calcium & mitochondrial duress 51 3.81E-7
15 SGTC_10 0279-0212 4.88 42.6 µM 1.36E-6 TRP & mitochondrial translation 68 5.27E-7
16 SGTC_2834 9001755 4.75 58.4 µM 2.54E-6 20 1.03E-6
17 SGTC_1742 st038235 4.56 28.9 µM 6.00E-6 mitochondrial stress 95 2.60E-6
18 SGTC_2349 9023730 4.21 187.1 µM 2.62E-5 17 1.27E-5
19 SGTC_596 1155-0152 4.15 116.0 µM 3.40E-5 TRP & mitochondrial translation 32 1.67E-5
20 SGTC_2682 pyrogallin 4.14 40.0 µM 3.53E-5 copper-dependent oxidative stress 23 1.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.382 3.31E-117 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.373 5.78E-111 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.361 1.91E-103 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.360 5.06E-103 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.353 1.31E-98 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.353 8.88E-99 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.352 2.69E-98 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.352 2.86E-98 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.347 1.57E-95 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.343 2.82E-93 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.343 3.04E-93 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.338 2.23E-90 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.337 1.46E-89 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.334 2.37E-88 YKR085C MRPL20 hom Mitochondrial ribosomal protein of the large subunit
0.333 1.29E-87 YDL045W-A MRP10 hom Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs