YFR020W_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR020W / YFR020W

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.01|P-value:4.73E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.84|P-value:9.70E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.93|P-value:6.45E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:-4.13|P-value:3.05E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.25|P-value:7.83E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.30|P-value:6.78E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.59|P-value:2.49E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.32|P-value:6.15E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.68|P-value:2.73E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.52|P-value:5.40E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.39|P-value:4.96E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:5.11|P-value:3.23E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.64|P-value:2.07E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.36|P-value:5.31E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.42|P-value:4.49E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.27|P-value:7.48E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.60|P-value:2.30E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.12|P-value:3.07E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.41|P-value:4.70E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.18|P-value:9.85E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.40|P-value:7.85E-8 ID:SGTC_2340|Compound:7987427|FD-Score:6.73|P-value:2.97E-11 ID:SGTC_2345|Compound:9052315|FD-Score:3.31|P-value:6.30E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.43|P-value:4.12E-4 ID:SGTC_2395|Compound:5646831|FD-Score:5.14|P-value:2.76E-7 ID:SGTC_2400|Compound:5203494|FD-Score:-3.28|P-value:7.43E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.73|P-value:1.39E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.40|P-value:4.84E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.30|P-value:6.54E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.28|P-value:7.00E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.91|P-value:8.83E-7 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:3.36E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.47|P-value:3.60E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.42|P-value:8.37E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.81|P-value:1.09E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.90|P-value:7.22E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.66|P-value:1.83E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.79|P-value:1.13E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.27|P-value:7.48E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.01|P-value:4.73E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.84|P-value:9.70E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.93|P-value:6.45E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:-4.13|P-value:3.05E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.25|P-value:7.83E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.30|P-value:6.78E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.59|P-value:2.49E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.32|P-value:6.15E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.68|P-value:2.73E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.52|P-value:5.40E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.39|P-value:4.96E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:5.11|P-value:3.23E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.64|P-value:2.07E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.36|P-value:5.31E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.51|P-value:3.27E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.42|P-value:4.49E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.27|P-value:7.48E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.60|P-value:2.30E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.12|P-value:3.07E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.41|P-value:4.70E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.18|P-value:9.85E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.40|P-value:7.85E-8 ID:SGTC_2340|Compound:7987427|FD-Score:6.73|P-value:2.97E-11 ID:SGTC_2345|Compound:9052315|FD-Score:3.31|P-value:6.30E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.43|P-value:4.12E-4 ID:SGTC_2395|Compound:5646831|FD-Score:5.14|P-value:2.76E-7 ID:SGTC_2400|Compound:5203494|FD-Score:-3.28|P-value:7.43E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.73|P-value:1.39E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.40|P-value:4.84E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.30|P-value:6.54E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.28|P-value:7.00E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.91|P-value:8.83E-7 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:3.36E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.47|P-value:3.60E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.42|P-value:8.37E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.81|P-value:1.09E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.90|P-value:7.22E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.66|P-value:1.83E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.61|P-value:2.21E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.79|P-value:1.13E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.27|P-value:7.48E-4

Top fitness defect scores for YFR020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2340 7987427 6.73 183.4 µM 2.97E-11 5 8.72E-12
2 SGTC_2395 5646831 5.14 180.2 µM 2.76E-7 11 1.35E-7
3 SGTC_1345 1488-0192 5.11 31.4 µM 3.23E-7 5 1.59E-7
4 SGTC_2628 lathosterol 4.91 100.0 µM 8.83E-7 14 4.59E-7
5 SGTC_1185 1319-0113 4.52 81.3 µM 5.40E-6 DNA damage response 7 3.10E-6
6 SGTC_2905 7799065 4.42 20.1 µM 8.37E-6 10 4.92E-6
7 SGTC_1634 st006576 4.12 41.0 µM 3.07E-5 TSC3-RPN4 17 1.94E-5
8 SGTC_2660 2',4'-dihydroxychalcone 4.09 17.1 µM 3.36E-5 15 2.13E-5
9 SGTC_181 1447-1644 4.01 8.1 µM 4.73E-5 endomembrane recycling 34 3.05E-5
10 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.93 8.0 µM 6.45E-5 26 4.23E-5
11 SGTC_3041 9091929 3.90 49.5 µM 7.22E-5 redox potentiating 21 4.76E-5
12 SGTC_3252 9135871 3.79 49.5 µM 1.13E-4 15 7.60E-5
13 SGTC_2401 5128683 3.73 200.0 µM 1.39E-4 49 9.46E-5
14 SGTC_3052 9092717 3.66 49.5 µM 1.83E-4 40 1.27E-4
15 SGTC_3185 9108267 3.61 49.5 µM 2.21E-4 60S ribosome export 25 1.55E-4
16 SGTC_1524 corynanthine 3.60 62.1 µM 2.30E-4 28 1.62E-4
17 SGTC_2832 7992762 3.47 52.0 µM 3.60E-4 46 2.58E-4
18 SGTC_1231 0242-0792 3.45 125.0 µM 3.82E-4 31 2.75E-4
19 SGTC_2357 9067248 3.43 200.0 µM 4.12E-4 39 2.98E-4
20 SGTC_1685 st024049 3.41 53.1 µM 4.45E-4 TSC3-RPN4 27 3.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.75E-11 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.105 9.17E-10 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.101 5.00E-9 YDR109C_p YDR109C_p hom Putative kinase
0.092 9.08E-8 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.87E-7 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.082 2.23E-6 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.079 5.27E-6 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.077 8.90E-6 YDL139C SCM3 het Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP
0.076 1.18E-5 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.075 1.37E-5 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.075 1.46E-5 YGR084C MRP13 hom Mitochondrial ribosomal protein of the small subunit
0.074 1.91E-5 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.071 4.12E-5 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.070 4.91E-5 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.067 9.73E-5 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data