HIPHOP chemogenomics database

YFR023W / PES4

Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR023W / PES4

Click on Significant Values for Screen Details

Top fitness defect scores for YFR023W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_747	3448-8087	6.17	38.7 µM	1.70E-9		2	3.47E-10
2	SGTC_2812	7970281	6.03	58.4 µM	3.84E-9		2	8.41E-10
3	SGTC_1120	ficusin	5.47	1.8 µM	7.93E-8		4	2.25E-8
4	SGTC_2312	7706453	5.28	155.7 µM	2.15E-7		10	6.63E-8
5	SGTC_2826	7992541	4.87	19.5 µM	1.57E-6		6	5.71E-7
6	SGTC_2097	5376186	4.64	200.0 µM	4.28E-6		8	1.70E-6
7	SGTC_2585	alliin	4.59	100.0 µM	5.43E-6		13	2.20E-6
8	SGTC_43	0570-0105	4.52	72.5 µM	7.36E-6	ERG2	69	3.06E-6
9	SGTC_541	4513-1321	4.50	94.0 µM	8.13E-6		14	3.41E-6
10	SGTC_1442	4112-3290	4.48	3.0 µM	8.70E-6		2	3.67E-6
11	SGTC_811	0416-0114	4.48	265.0 µM	8.74E-6		9	3.69E-6
12	SGTC_2344	7990960	4.42	77.0 µM	1.16E-5		19	5.00E-6
13	SGTC_3189	9110682	4.35	49.5 µM	1.51E-5		26	6.69E-6
14	SGTC_1815	st051655	4.16	58.2 µM	3.31E-5	TSC3-RPN4	9	1.56E-5
15	SGTC_2345	9052315	4.10	157.4 µM	4.29E-5		17	2.07E-5
16	SGTC_426	0988-0037	4.01	14.6 µM	6.11E-5	ERAD & cell cycle	30	3.04E-5
17	SGTC_1816	st051957	4.00	91.6 µM	6.25E-5		10	3.11E-5
18	SGTC_795	0685-0265	3.95	78.0 µM	7.87E-5	excess fatty acid	27	3.99E-5
19	SGTC_2259	7964009	3.85	200.0 µM	1.14E-4	superoxide	33	5.98E-5
20	SGTC_1236	0330-0013	3.84	258.0 µM	1.17E-4		10	6.13E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.133	9.05E-15	YPL019C	VTC3	hom	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.113	5.37E-11	YJL050W	MTR4	het	ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.104	1.70E-9	YOL058W	ARG1	hom	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.101	4.63E-9	YDR504C	SPG3	hom	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.084	9.51E-7	YJL146W	IDS2	hom	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.082	1.86E-6	YDR046C	BAP3	hom	Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.079	5.30E-6	YOL022C	TSR4	het	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.078	5.99E-6	YKL207W	EMC3	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.077	8.26E-6	YAL031C	GIP4	hom	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
0.076	1.01E-5	YGR080W	TWF1	hom	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
0.075	1.20E-5	YOR159C	SME1	het	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.075	1.49E-5	YOL140W	ARG8	hom	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.073	2.05E-5	YER166W	DNF1	hom	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.069	6.88E-5	YJL033W	HCA4	het	DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.068	8.56E-5	YDL190C	UFD2	hom	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3