YFR023W / PES4

Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR023W / PES4

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.52|P-value:7.36E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.31|P-value:7.52E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.01|P-value:6.11E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.66|P-value:3.87E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:4.50|P-value:8.13E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:6.17|P-value:1.70E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.95|P-value:7.87E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:4.48|P-value:8.74E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.33|P-value:1.60E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:5.47|P-value:7.93E-8 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.66|P-value:2.19E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.48|P-value:8.70E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.31|P-value:7.75E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.64|P-value:2.43E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.16|P-value:3.31E-5 ID:SGTC_1816|Compound:st051957|FD-Score:4.00|P-value:6.25E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-5.09|P-value:5.05E-7 ID:SGTC_1825|Compound:st052143|FD-Score:-3.61|P-value:2.63E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.24|P-value:9.26E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.43|P-value:4.86E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.64|P-value:4.28E-6 ID:SGTC_2101|Compound:5377231|FD-Score:-3.48|P-value:4.13E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.35|P-value:6.73E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.85|P-value:1.14E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.28|P-value:2.15E-7 ID:SGTC_2344|Compound:7990960|FD-Score:4.42|P-value:1.16E-5 ID:SGTC_2345|Compound:9052315|FD-Score:4.10|P-value:4.29E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.21|P-value:2.67E-5 ID:SGTC_2585|Compound:alliin|FD-Score:4.59|P-value:5.43E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.67|P-value:2.18E-4 ID:SGTC_2812|Compound:7970281|FD-Score:6.03|P-value:3.84E-9 ID:SGTC_2826|Compound:7992541|FD-Score:4.87|P-value:1.57E-6 ID:SGTC_2895|Compound:9054447|FD-Score:3.27|P-value:8.64E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.78|P-value:1.40E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.98|P-value:4.70E-9 ID:SGTC_3067|Compound:9117431|FD-Score:3.65|P-value:2.38E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.41|P-value:5.44E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.35|P-value:1.51E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.59|P-value:2.93E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.87|P-value:9.97E-5 ID:SGTC_3239|Compound:9133757|FD-Score:3.31|P-value:7.60E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.52|P-value:7.36E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.31|P-value:7.52E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.01|P-value:6.11E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.66|P-value:3.87E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:4.50|P-value:8.13E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:6.17|P-value:1.70E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.95|P-value:7.87E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:4.48|P-value:8.74E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.33|P-value:1.60E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:5.47|P-value:7.93E-8 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.66|P-value:2.19E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.39|P-value:5.88E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.48|P-value:8.70E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.31|P-value:7.75E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.64|P-value:2.43E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.16|P-value:3.31E-5 ID:SGTC_1816|Compound:st051957|FD-Score:4.00|P-value:6.25E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-5.09|P-value:5.05E-7 ID:SGTC_1825|Compound:st052143|FD-Score:-3.61|P-value:2.63E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.24|P-value:9.26E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.43|P-value:4.86E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.64|P-value:4.28E-6 ID:SGTC_2101|Compound:5377231|FD-Score:-3.48|P-value:4.13E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.35|P-value:6.73E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.85|P-value:1.14E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.28|P-value:2.15E-7 ID:SGTC_2344|Compound:7990960|FD-Score:4.42|P-value:1.16E-5 ID:SGTC_2345|Compound:9052315|FD-Score:4.10|P-value:4.29E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.21|P-value:2.67E-5 ID:SGTC_2585|Compound:alliin|FD-Score:4.59|P-value:5.43E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.67|P-value:2.18E-4 ID:SGTC_2812|Compound:7970281|FD-Score:6.03|P-value:3.84E-9 ID:SGTC_2826|Compound:7992541|FD-Score:4.87|P-value:1.57E-6 ID:SGTC_2895|Compound:9054447|FD-Score:3.27|P-value:8.64E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.78|P-value:1.40E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.98|P-value:4.70E-9 ID:SGTC_3067|Compound:9117431|FD-Score:3.65|P-value:2.38E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.41|P-value:5.44E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.35|P-value:1.51E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.59|P-value:2.93E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.87|P-value:9.97E-5 ID:SGTC_3239|Compound:9133757|FD-Score:3.31|P-value:7.60E-4

Top fitness defect scores for YFR023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_747 3448-8087 6.17 38.7 µM 1.70E-9 2 3.47E-10
2 SGTC_2812 7970281 6.03 58.4 µM 3.84E-9 2 8.41E-10
3 SGTC_1120 ficusin 5.47 1.8 µM 7.93E-8 4 2.25E-8
4 SGTC_2312 7706453 5.28 155.7 µM 2.15E-7 10 6.63E-8
5 SGTC_2826 7992541 4.87 19.5 µM 1.57E-6 6 5.71E-7
6 SGTC_2097 5376186 4.64 200.0 µM 4.28E-6 8 1.70E-6
7 SGTC_2585 alliin 4.59 100.0 µM 5.43E-6 13 2.20E-6
8 SGTC_43 0570-0105 4.52 72.5 µM 7.36E-6 ERG2 69 3.06E-6
9 SGTC_541 4513-1321 4.50 94.0 µM 8.13E-6 14 3.41E-6
10 SGTC_1442 4112-3290 4.48 3.0 µM 8.70E-6 2 3.67E-6
11 SGTC_811 0416-0114 4.48 265.0 µM 8.74E-6 9 3.69E-6
12 SGTC_2344 7990960 4.42 77.0 µM 1.16E-5 19 5.00E-6
13 SGTC_3189 9110682 4.35 49.5 µM 1.51E-5 26 6.69E-6
14 SGTC_1815 st051655 4.16 58.2 µM 3.31E-5 TSC3-RPN4 9 1.56E-5
15 SGTC_2345 9052315 4.10 157.4 µM 4.29E-5 17 2.07E-5
16 SGTC_426 0988-0037 4.01 14.6 µM 6.11E-5 ERAD & cell cycle 30 3.04E-5
17 SGTC_1816 st051957 4.00 91.6 µM 6.25E-5 10 3.11E-5
18 SGTC_795 0685-0265 3.95 78.0 µM 7.87E-5 excess fatty acid 27 3.99E-5
19 SGTC_2259 7964009 3.85 200.0 µM 1.14E-4 superoxide 33 5.98E-5
20 SGTC_1236 0330-0013 3.84 258.0 µM 1.17E-4 10 6.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.05E-15 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.113 5.37E-11 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.104 1.70E-9 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.101 4.63E-9 YDR504C SPG3 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.084 9.51E-7 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.082 1.86E-6 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.079 5.30E-6 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.078 5.99E-6 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.077 8.26E-6 YAL031C GIP4 hom Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
0.076 1.01E-5 YGR080W TWF1 hom Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
0.075 1.20E-5 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.075 1.49E-5 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.073 2.05E-5 YER166W DNF1 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.069 6.88E-5 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.068 8.56E-5 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3