YFR026C / ULI1

Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR026C / ULI1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.92|P-value:3.98E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.57|P-value:1.79E-11 ID:SGTC_162|Compound:k030-0015|FD-Score:5.43|P-value:2.21E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:3.82|P-value:5.93E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.83|P-value:5.76E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.08|P-value:9.85E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.27|P-value:4.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.70|P-value:9.16E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.68|P-value:9.97E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.12|P-value:8.36E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.23|P-value:5.42E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.39|P-value:3.23E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.24|P-value:5.15E-4 ID:SGTC_1628|Compound:st004252|FD-Score:6.00|P-value:7.51E-10 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.39|P-value:3.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:5.97E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.72|P-value:9.91E-7 ID:SGTC_2074|Compound:5212007|FD-Score:3.48|P-value:2.28E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.18|P-value:6.92E-4 ID:SGTC_2319|Compound:6033012|FD-Score:6.08|P-value:4.62E-10 ID:SGTC_2371|Compound:9071574|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.92|P-value:4.02E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.51|P-value:1.90E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.88|P-value:4.37E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:5.15|P-value:1.05E-7 ID:SGTC_2956|Compound:9076196|FD-Score:3.18|P-value:6.86E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.92|P-value:3.98E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.57|P-value:1.79E-11 ID:SGTC_162|Compound:k030-0015|FD-Score:5.43|P-value:2.21E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:3.82|P-value:5.93E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.83|P-value:5.76E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.08|P-value:9.85E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.27|P-value:4.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.70|P-value:9.16E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.68|P-value:9.97E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.12|P-value:8.36E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.23|P-value:5.42E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.39|P-value:3.23E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.24|P-value:5.15E-4 ID:SGTC_1628|Compound:st004252|FD-Score:6.00|P-value:7.51E-10 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.39|P-value:3.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:5.97E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.72|P-value:9.91E-7 ID:SGTC_2074|Compound:5212007|FD-Score:3.48|P-value:2.28E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.18|P-value:6.92E-4 ID:SGTC_2319|Compound:6033012|FD-Score:6.08|P-value:4.62E-10 ID:SGTC_2371|Compound:9071574|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.92|P-value:4.02E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.51|P-value:1.90E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.88|P-value:4.37E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:5.15|P-value:1.05E-7 ID:SGTC_2956|Compound:9076196|FD-Score:3.18|P-value:6.86E-4

Top fitness defect scores for YFR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_87 0100-0052 6.57 35.5 µM 1.79E-11 24 2.53E-11
2 SGTC_2319 6033012 6.08 152.6 µM 4.62E-10 tubulin folding & SWR complex 14 6.20E-10
3 SGTC_1628 st004252 6.00 77.7 µM 7.51E-10 2 9.99E-10
4 SGTC_162 k030-0015 5.43 37.8 µM 2.21E-8 iron homeostasis 4 2.78E-8
5 SGTC_2607 solasodine 5.15 47.4 µM 1.05E-7 34 1.29E-7
6 SGTC_170 4197-0004 4.83 226.0 µM 5.76E-7 8 6.88E-7
7 SGTC_2062 5245942 4.72 200.0 µM 9.91E-7 2 1.17E-6
8 SGTC_86 0417-1630 3.92 471.9 µM 3.98E-5 ubiquinone biosynthesis & proteasome 152 4.45E-5
9 SGTC_2376 9072922 3.92 81.3 µM 4.02E-5 31 4.50E-5
10 SGTC_165 k038-0023 3.82 64.4 µM 5.93E-5 ubiquinone biosynthesis & proteasome 86 6.59E-5
11 SGTC_2371 9071574 3.49 200.0 µM 2.20E-4 24 2.40E-4
12 SGTC_2074 5212007 3.48 75.4 µM 2.28E-4 21 2.49E-4
13 SGTC_781 4335-2806 3.47 94.4 µM 2.39E-4 34 2.60E-4
14 SGTC_494 Boc-Gly-Val-Val-CHO 3.39 140.0 µM 3.23E-4 16 3.51E-4
15 SGTC_2492 derrusnin 3.31 100.0 µM 4.35E-4 14 4.69E-4
16 SGTC_2956 9076196 3.18 2.5 µM 6.86E-4 57 7.35E-4
17 SGTC_2311 7694451 3.18 200.0 µM 6.92E-4 56 7.42E-4
18 SGTC_448 monastrol 3.12 171.0 µM 8.36E-4 25 8.94E-4
19 SGTC_178 4092-0806 3.08 87.5 µM 9.85E-4 ergosterol depletion effects on membrane 151 0.00105
20 SGTC_1288 0973-0013 2.99 65.5 µM 0.00130 52 0.00138

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.35E-31 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.183 1.41E-26 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.164 1.11E-21 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.136 2.37E-15 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.127 1.36E-13 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.125 3.69E-13 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.120 3.56E-12 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.117 1.23E-11 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.114 3.06E-11 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.114 3.32E-11 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.113 6.40E-11 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.111 1.38E-10 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.110 1.73E-10 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.109 2.50E-10 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.107 5.41E-10 YMR019W STB4 hom Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;