YFR027W / ECO1

Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR027W / ECO1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.89|P-value:9.31E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.94|P-value:3.66E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.25|P-value:9.22E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.97|P-value:2.30E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.79|P-value:6.02E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.49|P-value:2.90E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.74|P-value:8.27E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.07|P-value:1.99E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.70|P-value:9.09E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.88|P-value:4.54E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.23|P-value:9.58E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.82|P-value:5.74E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.30|P-value:3.69E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:3.35|P-value:5.65E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.02|P-value:2.43E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.94|P-value:3.45E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.73|P-value:8.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.92|P-value:4.61E-12 ID:SGTC_1117|Compound:retinoic acid|FD-Score:2.69|P-value:9.54E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.77|P-value:7.24E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.34|P-value:5.95E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.28|P-value:7.80E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.56|P-value:7.31E-8 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.23|P-value:1.01E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.40|P-value:4.48E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.94|P-value:2.72E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-4.28|P-value:4.18E-7 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.94|P-value:3.42E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.71|P-value:8.73E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.75|P-value:7.83E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.07|P-value:2.10E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.09|P-value:1.19E-6 ID:SGTC_2048|Compound:5246248|FD-Score:3.15|P-value:1.40E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.04|P-value:1.58E-6 ID:SGTC_2197|Compound:6588183|FD-Score:-3.04|P-value:2.35E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.39|P-value:2.05E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.73|P-value:8.10E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-2.80|P-value:6.32E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.66|P-value:1.19E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.89|P-value:9.31E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-2.94|P-value:3.66E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.25|P-value:9.22E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.97|P-value:2.30E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.79|P-value:6.02E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:3.49|P-value:2.90E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.74|P-value:8.27E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.07|P-value:1.99E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.70|P-value:9.09E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.88|P-value:4.54E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.23|P-value:9.58E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.82|P-value:5.74E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.30|P-value:3.69E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:3.35|P-value:5.65E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.02|P-value:2.43E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.94|P-value:3.45E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.73|P-value:8.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.92|P-value:4.61E-12 ID:SGTC_1117|Compound:retinoic acid|FD-Score:2.69|P-value:9.54E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.77|P-value:7.24E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.34|P-value:5.95E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.28|P-value:7.80E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.56|P-value:7.31E-8 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.23|P-value:1.01E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.40|P-value:4.48E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.94|P-value:2.72E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-4.28|P-value:4.18E-7 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.94|P-value:3.42E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.71|P-value:8.73E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.75|P-value:7.83E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.07|P-value:2.10E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.09|P-value:1.19E-6 ID:SGTC_2048|Compound:5246248|FD-Score:3.15|P-value:1.40E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.04|P-value:1.58E-6 ID:SGTC_2197|Compound:6588183|FD-Score:-3.04|P-value:2.35E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.39|P-value:2.05E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.73|P-value:8.10E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-2.80|P-value:6.32E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.66|P-value:1.19E-5

Top fitness defect scores for YFR027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1176 0848-0131 4.56 83.3 µM 7.31E-8 Golgi 2 2.58E-6 0.77
2 SGTC_2295 7971645 4.39 200.0 µM 2.05E-7 4 5.63E-6 0.46
3 SGTC_2035 5154463 4.09 94.6 µM 1.19E-6 10 2.16E-5 2.07E-4
4 SGTC_2196 6573537 4.04 42.7 µM 1.58E-6 copper-dependent oxidative stress 2 2.67E-5 0.44
5 SGTC_153 4077-0274 3.97 519.7 µM 2.30E-6 6 3.56E-5 0.10
6 SGTC_1263 0774-1208 3.94 64.8 µM 2.72E-6 3 4.04E-5 0.13
7 SGTC_155 k072-0202 3.79 43.6 µM 6.02E-6 5 7.40E-5 0.03
8 SGTC_2327 6189656 3.66 200.0 µM 1.19E-5 10 1.25E-4 0.02
9 SGTC_156 3474-0145 3.49 5.6 µM 2.90E-5 endomembrane recycling 11 2.46E-4 0.49
10 SGTC_1261 0712-0010 3.40 12.7 µM 4.48E-5 RNA processing & uracil transport 13 3.42E-4 0.01
11 SGTC_780 0109-0199 3.35 192.0 µM 5.65E-5 8 4.09E-4 0.02
12 SGTC_1169 aniline yellow 3.28 25.8 µM 7.80E-5 3 5.24E-4 0.02
13 SGTC_459 nigericin 3.23 15.3 µM 9.58E-5 17 6.13E-4 0.14
14 SGTC_2048 5246248 3.15 200.0 µM 1.40E-4 6 8.21E-4 0.25
15 SGTC_370 0180-0345 3.07 38.7 µM 1.99E-4 DNA intercalators 15 0.00107 0.01
16 SGTC_1058 3448-5425 3.02 97.3 µM 2.43E-4 21 0.00125 0.02
17 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 2.94 66.5 µM 3.42E-4 11 0.00163 0.05
18 SGTC_1059 3448-6867 2.94 171.0 µM 3.45E-4 20 0.00164 0.04
19 SGTC_639 0833-0042 2.82 114.0 µM 5.74E-4 15 0.00242 0.00
20 SGTC_2298 7976326 2.73 193.8 µM 8.10E-4 3 0.00315 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 3.46E-41 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.224 2.34E-39 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213 9.16E-36 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.211 3.03E-35 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.208 5.12E-34 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.206 2.41E-33 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.200 1.38E-31 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.195 3.95E-30 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.191 6.42E-29 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.190 1.17E-28 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.185 3.88E-27 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.181 4.58E-26 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.180 6.75E-26 YLR267W_p BOP2_p hom Protein of unknown function
0.179 1.30E-25 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.176 7.34E-25 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER