YFR029W / PTR3

Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR029W / PTR3

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.83|P-value:9.21E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:3.17|P-value:1.86E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.05|P-value:3.14E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.64|P-value:2.25E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.58|P-value:3.15E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.77|P-value:9.62E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.50|P-value:2.36E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:5.62E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.53|P-value:3.82E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.38|P-value:7.55E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.77|P-value:9.96E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.10|P-value:2.51E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:2.83|P-value:7.51E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.90|P-value:6.08E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.46|P-value:5.14E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.98|P-value:4.18E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.91|P-value:5.44E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.97|P-value:4.52E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.78|P-value:9.10E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.16|P-value:2.06E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.26|P-value:1.35E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.88|P-value:6.15E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.53|P-value:3.84E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.66|P-value:2.10E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.34|P-value:8.91E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.33|P-value:1.00E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.09|P-value:2.74E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.41|P-value:6.71E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-2.85|P-value:7.13E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.77|P-value:9.50E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.09|P-value:6.00E-9 ID:SGTC_2177|Compound:5811945|FD-Score:7.20|P-value:3.78E-16 ID:SGTC_2179|Compound:6298986|FD-Score:4.15|P-value:1.61E-6 ID:SGTC_2181|Compound:6316240|FD-Score:-2.97|P-value:4.51E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.94|P-value:4.97E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.84|P-value:7.37E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.37|P-value:8.04E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.16|P-value:1.56E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.73|P-value:1.42E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.19|P-value:1.35E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.24|P-value:1.07E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.70|P-value:7.27E-8 ID:SGTC_2798|Compound:7813637|FD-Score:3.28|P-value:1.16E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.34|P-value:9.62E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.54|P-value:3.62E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.14|P-value:1.72E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-2.91|P-value:5.65E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.92|P-value:5.78E-6 ID:SGTC_3186|Compound:9110464|FD-Score:2.77|P-value:9.34E-4 ID:SGTC_3308|Compound:9128332|FD-Score:2.87|P-value:6.46E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.83|P-value:9.21E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:3.17|P-value:1.86E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.05|P-value:3.14E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.64|P-value:2.25E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.58|P-value:3.15E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.77|P-value:9.62E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.50|P-value:2.36E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:5.62E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.53|P-value:3.82E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.38|P-value:7.55E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.77|P-value:9.96E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.10|P-value:2.51E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.15|P-value:2.16E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:2.83|P-value:7.51E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.90|P-value:6.08E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.46|P-value:5.14E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.98|P-value:4.18E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.91|P-value:5.44E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.97|P-value:4.52E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.78|P-value:9.10E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.16|P-value:2.06E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.26|P-value:1.35E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.88|P-value:6.15E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.53|P-value:3.84E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.66|P-value:2.10E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.34|P-value:8.91E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.33|P-value:1.00E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.09|P-value:2.74E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.41|P-value:6.71E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-2.85|P-value:7.13E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.77|P-value:9.50E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.09|P-value:6.00E-9 ID:SGTC_2177|Compound:5811945|FD-Score:7.20|P-value:3.78E-16 ID:SGTC_2179|Compound:6298986|FD-Score:4.15|P-value:1.61E-6 ID:SGTC_2181|Compound:6316240|FD-Score:-2.97|P-value:4.51E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.94|P-value:4.97E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.84|P-value:7.37E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.37|P-value:8.04E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.16|P-value:1.56E-6 ID:SGTC_2393|Compound:9031399|FD-Score:3.73|P-value:1.42E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.19|P-value:1.35E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:-4.24|P-value:1.07E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.70|P-value:7.27E-8 ID:SGTC_2798|Compound:7813637|FD-Score:3.28|P-value:1.16E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.34|P-value:9.62E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.54|P-value:3.62E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.14|P-value:1.72E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-2.91|P-value:5.65E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.92|P-value:5.78E-6 ID:SGTC_3186|Compound:9110464|FD-Score:2.77|P-value:9.34E-4 ID:SGTC_3308|Compound:9128332|FD-Score:2.87|P-value:6.46E-4

Top fitness defect scores for YFR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2177 5811945 7.20 192.0 µM 3.78E-16 1 3.11E-13 1.94
2 SGTC_2167 5876490 5.09 200.0 µM 6.00E-9 1 1.83E-7 1.83
3 SGTC_2751 anetholtrithion 4.19 17.2 µM 1.35E-6 6 1.42E-5 0.00
4 SGTC_2363 9053361 4.16 176.0 µM 1.56E-6 Golgi 10 1.59E-5 0.10
5 SGTC_2179 6298986 4.15 200.0 µM 1.61E-6 heme requiring 5 1.63E-5 0.32
6 SGTC_2919 7978188 4.14 46.4 µM 1.72E-6 2 1.72E-5 0.06
7 SGTC_2393 9031399 3.73 185.9 µM 1.42E-5 RNA processing & uracil transport 15 9.41E-5 0.14
8 SGTC_188 3229-0966 3.64 278.5 µM 2.25E-5 22 1.37E-4 0.03
9 SGTC_2918 7977171 3.54 22.1 µM 3.62E-5 7 2.01E-4 0.36
10 SGTC_665 3914-0008 3.53 307.0 µM 3.82E-5 4 2.09E-4 0.05
11 SGTC_1607 st000305 3.53 50.6 µM 3.84E-5 6 2.10E-4 0.15
12 SGTC_875 0709-0210 3.46 25.7 µM 5.14E-5 fatty acid desaturase (OLE1) 15 2.66E-4 0.18
13 SGTC_1713 st033146 3.41 12.8 µM 6.71E-5 14 3.30E-4 0.07
14 SGTC_713 1488-1073 3.38 324.0 µM 7.55E-5 ERG2 6 3.63E-4 0.23
15 SGTC_2362 9071156 3.37 126.0 µM 8.04E-5 7 3.82E-4 0.01
16 SGTC_1615 st002656 3.34 86.5 µM 8.91E-5 redox potentiating 10 4.15E-4 0.20
17 SGTC_2798 7813637 3.28 45.5 µM 1.16E-4 21 5.14E-4 0.00
18 SGTC_1716 st033144 3.27 30.6 µM 1.25E-4 10 5.44E-4 0.02
19 SGTC_1261 0712-0010 3.26 12.7 µM 1.30E-4 RNA processing & uracil transport 16 5.61E-4 0.13
20 SGTC_81 0411-0046 3.17 10.0 µM 1.86E-4 47 7.52E-4 4.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.99E-10 YBR225W_p YBR225W_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
0.102 3.25E-9 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.095 4.05E-8 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.091 1.49E-7 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.090 1.52E-7 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.090 1.78E-7 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.090 1.97E-7 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.088 3.15E-7 YEL010W_d YEL010W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.96E-7 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.086 6.23E-7 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.085 8.77E-7 YBR119W MUD1 hom U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
0.082 2.16E-6 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.080 3.14E-6 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.077 8.84E-6 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.076 9.71E-6 YPR094W RDS3 het Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance