Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFR030W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.107 | 4.74E-10 | YGR204W | ADE3 | hom | Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine |
0.107 | 5.33E-10 | YER147C | SCC4 | het | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX |
0.106 | 6.29E-10 | YOR226C | ISU2 | hom | Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved |
0.097 | 1.60E-8 | YLR351C | NIT3 | hom | Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member |
0.093 | 7.29E-8 | YPR040W | TIP41 | hom | Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress |
0.090 | 1.59E-7 | YIL143C | SSL2 | het | Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3 |
0.088 | 2.84E-7 | YPR050C_d | YPR050C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W |
0.088 | 3.84E-7 | YMR082C_d | YMR082C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.083 | 1.47E-6 | YHL021C | AIM17 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss |
0.083 | 1.55E-6 | YPL173W | MRPL40 | hom | Mitochondrial ribosomal protein of the large subunit |
0.082 | 1.80E-6 | YGR094W | VAS1 | het | Mitochondrial and cytoplasmic valyl-tRNA synthetase |
0.082 | 2.14E-6 | YLR438W | CAR2 | hom | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress |
0.081 | 2.52E-6 | YDL153C | SAS10 | het | Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance |
0.080 | 3.37E-6 | YLL040C | VPS13 | hom | Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively |
0.079 | 4.61E-6 | YOL150C_d | YOL150C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |