YFR030W / MET10

Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR030W / MET10

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.68|P-value:1.46E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.60|P-value:3.25E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.37|P-value:7.61E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.18|P-value:1.44E-7 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.23|P-value:6.82E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.13|P-value:2.18E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.87|P-value:6.76E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.92|P-value:5.24E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.74|P-value:6.58E-9 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.14|P-value:2.06E-5 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.87|P-value:6.37E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.47|P-value:2.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.82|P-value:7.67E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.50|P-value:4.19E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.61|P-value:1.75E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.03|P-value:3.30E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.55|P-value:2.32E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1852|Compound:st056254|FD-Score:5.41|P-value:4.38E-8 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:5.05|P-value:2.86E-7 ID:SGTC_1956|Compound:st077085|FD-Score:5.87|P-value:3.20E-9 ID:SGTC_1998|Compound:st075797|FD-Score:5.07|P-value:2.57E-7 ID:SGTC_2087|Compound:5276107|FD-Score:5.31|P-value:7.20E-8 ID:SGTC_2119|Compound:5528445|FD-Score:4.07|P-value:2.81E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.85|P-value:3.49E-9 ID:SGTC_2307|Compound:7538926|FD-Score:3.19|P-value:7.95E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.87|P-value:6.30E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.26|P-value:6.68E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.24|P-value:1.32E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.47|P-value:2.93E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.31|P-value:5.27E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.40|P-value:3.77E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.84|P-value:8.23E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.17|P-value:8.41E-4 ID:SGTC_3068|Compound:9116768|FD-Score:5.76|P-value:5.82E-9 ID:SGTC_3074|Compound:9116018|FD-Score:4.11|P-value:2.38E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.17|P-value:8.83E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.68|P-value:1.46E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.60|P-value:3.25E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.37|P-value:7.61E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.18|P-value:1.44E-7 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.23|P-value:6.82E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.13|P-value:2.18E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.87|P-value:6.76E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.92|P-value:5.24E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.74|P-value:6.58E-9 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.14|P-value:2.06E-5 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.87|P-value:6.37E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.47|P-value:2.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.82|P-value:7.67E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.50|P-value:4.19E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.61|P-value:1.75E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.03|P-value:3.30E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.55|P-value:2.32E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1852|Compound:st056254|FD-Score:5.41|P-value:4.38E-8 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:5.05|P-value:2.86E-7 ID:SGTC_1956|Compound:st077085|FD-Score:5.87|P-value:3.20E-9 ID:SGTC_1998|Compound:st075797|FD-Score:5.07|P-value:2.57E-7 ID:SGTC_2087|Compound:5276107|FD-Score:5.31|P-value:7.20E-8 ID:SGTC_2119|Compound:5528445|FD-Score:4.07|P-value:2.81E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.85|P-value:3.49E-9 ID:SGTC_2307|Compound:7538926|FD-Score:3.19|P-value:7.95E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.87|P-value:6.30E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.54|P-value:2.40E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.26|P-value:6.68E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.24|P-value:1.32E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.47|P-value:2.93E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.31|P-value:5.27E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.40|P-value:3.77E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.84|P-value:8.23E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.17|P-value:8.41E-4 ID:SGTC_3068|Compound:9116768|FD-Score:5.76|P-value:5.82E-9 ID:SGTC_3074|Compound:9116018|FD-Score:4.11|P-value:2.38E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.17|P-value:8.83E-4

Top fitness defect scores for YFR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_119 0121-0043 6.60 24.8 µM 3.25E-11 mitochondrial stress 19 2.03E-11
2 SGTC_1956 st077085 5.87 54.0 µM 3.20E-9 2 2.21E-9
3 SGTC_2286 7945697 5.85 125.0 µM 3.49E-9 15 2.42E-9
4 SGTC_3068 9116768 5.76 49.5 µM 5.82E-9 4 4.08E-9
5 SGTC_430 0958-0115 5.74 16.4 µM 6.58E-9 8 4.63E-9
6 SGTC_1852 st056254 5.41 31.4 µM 4.38E-8 3 3.22E-8
7 SGTC_2087 5276107 5.31 200.0 µM 7.20E-8 3 5.34E-8
8 SGTC_257 daunorubicin 5.18 18.5 µM 1.44E-7 anthracycline transcription coupled DNA repair 15 1.08E-7
9 SGTC_1998 st075797 5.07 76.8 µM 2.57E-7 mitochondrial response to ROS 5 1.96E-7
10 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 5.05 62.6 µM 2.86E-7 TSC3-RPN4 7 2.19E-7
11 SGTC_2926 9010726 4.84 65.2 µM 8.23E-7 16 6.43E-7
12 SGTC_820 1582-0060 4.50 59.9 µM 4.19E-6 21 3.39E-6
13 SGTC_123 0083-0120 4.37 66.7 µM 7.61E-6 38 6.24E-6
14 SGTC_2604 4'-hydroxychalcone 4.24 11.3 µM 1.32E-5 29 1.10E-5
15 SGTC_449 xestospongin c 4.14 11.2 µM 2.06E-5 NEO1-PIK1 59 1.73E-5
16 SGTC_265 mycophenolic acid 4.13 32.9 µM 2.18E-5 RPP1 & pyrimidine depletion 13 1.83E-5
17 SGTC_3074 9116018 4.11 49.5 µM 2.38E-5 RNA processing & uracil transport 19 2.00E-5
18 SGTC_2119 5528445 4.07 120.6 µM 2.81E-5 14 2.37E-5
19 SGTC_1131 3454-3128 4.03 32.3 µM 3.30E-5 43 2.79E-5
20 SGTC_285 1486-1325 3.92 46.0 µM 5.24E-5 20 4.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.74E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.107 5.33E-10 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.106 6.29E-10 YOR226C ISU2 hom Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved
0.097 1.60E-8 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.093 7.29E-8 YPR040W TIP41 hom Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
0.090 1.59E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.088 2.84E-7 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.088 3.84E-7 YMR082C_d YMR082C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.47E-6 YHL021C AIM17 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.083 1.55E-6 YPL173W MRPL40 hom Mitochondrial ribosomal protein of the large subunit
0.082 1.80E-6 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.082 2.14E-6 YLR438W CAR2 hom L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
0.081 2.52E-6 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.080 3.37E-6 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.079 4.61E-6 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data