HIPHOP chemogenomics database

YFR030W / MET10

Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR030W / MET10

Click on Significant Values for Screen Details

Top fitness defect scores for YFR030W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_119	0121-0043	6.60	24.8 µM	3.25E-11	mitochondrial stress	19	2.03E-11
2	SGTC_1956	st077085	5.87	54.0 µM	3.20E-9		2	2.21E-9
3	SGTC_2286	7945697	5.85	125.0 µM	3.49E-9		15	2.42E-9
4	SGTC_3068	9116768	5.76	49.5 µM	5.82E-9		4	4.08E-9
5	SGTC_430	0958-0115	5.74	16.4 µM	6.58E-9		8	4.63E-9
6	SGTC_1852	st056254	5.41	31.4 µM	4.38E-8		3	3.22E-8
7	SGTC_2087	5276107	5.31	200.0 µM	7.20E-8		3	5.34E-8
8	SGTC_257	daunorubicin	5.18	18.5 µM	1.44E-7	anthracycline transcription coupled DNA repair	15	1.08E-7
9	SGTC_1998	st075797	5.07	76.8 µM	2.57E-7	mitochondrial response to ROS	5	1.96E-7
10	SGTC_1858	4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione	5.05	62.6 µM	2.86E-7	TSC3-RPN4	7	2.19E-7
11	SGTC_2926	9010726	4.84	65.2 µM	8.23E-7		16	6.43E-7
12	SGTC_820	1582-0060	4.50	59.9 µM	4.19E-6		21	3.39E-6
13	SGTC_123	0083-0120	4.37	66.7 µM	7.61E-6		38	6.24E-6
14	SGTC_2604	4'-hydroxychalcone	4.24	11.3 µM	1.32E-5		29	1.10E-5
15	SGTC_449	xestospongin c	4.14	11.2 µM	2.06E-5	NEO1-PIK1	59	1.73E-5
16	SGTC_265	mycophenolic acid	4.13	32.9 µM	2.18E-5	RPP1 & pyrimidine depletion	13	1.83E-5
17	SGTC_3074	9116018	4.11	49.5 µM	2.38E-5	RNA processing & uracil transport	19	2.00E-5
18	SGTC_2119	5528445	4.07	120.6 µM	2.81E-5		14	2.37E-5
19	SGTC_1131	3454-3128	4.03	32.3 µM	3.30E-5		43	2.79E-5
20	SGTC_285	1486-1325	3.92	46.0 µM	5.24E-5		20	4.48E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.107	4.74E-10	YGR204W	ADE3	hom	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.107	5.33E-10	YER147C	SCC4	het	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.106	6.29E-10	YOR226C	ISU2	hom	Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved
0.097	1.60E-8	YLR351C	NIT3	hom	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.093	7.29E-8	YPR040W	TIP41	hom	Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
0.090	1.59E-7	YIL143C	SSL2	het	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.088	2.84E-7	YPR050C_d	YPR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.088	3.84E-7	YMR082C_d	YMR082C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083	1.47E-6	YHL021C	AIM17	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.083	1.55E-6	YPL173W	MRPL40	hom	Mitochondrial ribosomal protein of the large subunit
0.082	1.80E-6	YGR094W	VAS1	het	Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.082	2.14E-6	YLR438W	CAR2	hom	L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
0.081	2.52E-6	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.080	3.37E-6	YLL040C	VPS13	hom	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.079	4.61E-6	YOL150C_d	YOL150C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data