YFR031C / SMC2

Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR031C / SMC2

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.42|P-value:1.85E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.10|P-value:6.17E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.23|P-value:6.43E-18 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:3.18|P-value:4.75E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.68|P-value:6.30E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.98|P-value:1.74E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.05|P-value:7.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.70|P-value:5.85E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.26|P-value:3.55E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.18|P-value:4.92E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.47|P-value:1.77E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.40|P-value:2.05E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.65|P-value:7.21E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.09|P-value:6.78E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.38|P-value:2.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.86|P-value:2.98E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.58|P-value:9.57E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.04|P-value:8.18E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.17|P-value:4.83E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.58|P-value:9.57E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.02|P-value:1.47E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.60|P-value:8.59E-7 ID:SGTC_2602|Compound:kawain|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.34|P-value:2.55E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.52|P-value:1.23E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.92|P-value:2.28E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.20|P-value:6.34E-6 ID:SGTC_3104|Compound:9120930|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.20|P-value:4.27E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.74|P-value:5.14E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.91|P-value:2.48E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.27|P-value:3.36E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.31|P-value:2.96E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.42|P-value:1.85E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.10|P-value:6.17E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.23|P-value:6.43E-18 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:3.18|P-value:4.75E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.68|P-value:6.30E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.98|P-value:1.74E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.05|P-value:7.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.70|P-value:5.85E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.26|P-value:3.55E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.18|P-value:4.92E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.99|P-value:9.29E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.47|P-value:1.77E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.40|P-value:2.05E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.65|P-value:7.21E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.01|P-value:8.64E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.09|P-value:6.78E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.38|P-value:2.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.86|P-value:2.98E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.58|P-value:9.57E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.04|P-value:8.18E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.17|P-value:4.83E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.58|P-value:9.57E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.02|P-value:1.47E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.60|P-value:8.59E-7 ID:SGTC_2602|Compound:kawain|FD-Score:-3.11|P-value:6.31E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.34|P-value:2.55E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.52|P-value:1.23E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.92|P-value:2.28E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.01|P-value:1.52E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.20|P-value:6.34E-6 ID:SGTC_3104|Compound:9120930|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.20|P-value:4.27E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.74|P-value:5.14E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.91|P-value:2.48E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.27|P-value:3.36E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.31|P-value:2.96E-4

Top fitness defect scores for YFR031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2596 sinensetin 4.60 100.0 µM 8.59E-7 2 2.13E-6 0.45
2 SGTC_3102 9121669 4.20 49.5 µM 6.34E-6 3 1.36E-5 0.08
3 SGTC_2565 isoliquiritigenin 4.02 100.0 µM 1.47E-5 10 2.96E-5 0.07
4 SGTC_3059 1327-0034 4.01 3.0 µM 1.52E-5 11 3.06E-5 0.13
5 SGTC_408 cantharidin 3.98 100.0 µM 1.74E-5 cell wall signaling 10 3.46E-5 0.08
6 SGTC_3045 9092950 3.92 49.5 µM 2.28E-5 4 4.47E-5 0.53
7 SGTC_2370 9071495 3.86 200.0 µM 2.98E-5 mitochondrial processes 12 5.72E-5 0.21
8 SGTC_456 gingerol 3.70 170.0 µM 5.85E-5 6 1.07E-4 0.21
9 SGTC_321 4534-3890 3.68 65.3 µM 6.30E-5 RPP1 & pyrimidine depletion 9 1.15E-4 0.00
10 SGTC_1632 st005650 3.65 90.0 µM 7.21E-5 8 1.30E-4 0.13
11 SGTC_2546 rhodinyl acetate 3.58 100.0 µM 9.57E-5 10 1.69E-4 0.01
12 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.58 200.0 µM 9.57E-5 8 1.69E-4 0.06
13 SGTC_1674 st016616 3.54 23.6 µM 1.14E-4 12 1.99E-4 0.10
14 SGTC_2947 9072639 3.52 7.7 µM 1.23E-4 tubulin folding & SWR complex 14 2.13E-4 3.90E-4
15 SGTC_115 0527-0192 3.42 112.0 µM 1.85E-4 36 3.11E-4 0.02
16 SGTC_1627 st003713 3.40 25.6 µM 2.05E-4 calcium & mitochondrial duress 14 3.43E-4 0.06
17 SGTC_2938 9059746 3.34 27.3 µM 2.55E-4 fatty acid desaturase (OLE1) 19 4.19E-4 0.08
18 SGTC_2882 9058044 3.33 58.4 µM 2.63E-4 14 4.33E-4 0.10
19 SGTC_3263 9137018 3.27 49.5 µM 3.36E-4 8 5.42E-4 0.00
20 SGTC_3104 9120930 3.25 49.5 µM 3.59E-4 7 5.77E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.50E-22 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.164 1.17E-21 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.158 3.64E-20 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.157 6.81E-20 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.146 2.39E-17 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.144 5.55E-17 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.140 3.68E-16 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.135 4.52E-15 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.132 2.08E-14 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.130 4.21E-14 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.129 5.44E-14 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.124 4.84E-13 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.122 1.56E-12 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.121 2.02E-12 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.121 2.10E-12 YDR292C SRP101 het Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p