YFR033C / QCR6

Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR033C / QCR6

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:4.97|P-value:1.54E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.87|P-value:2.48E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.49|P-value:1.28E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.63|P-value:6.44E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.97|P-value:1.60E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:5.22E-32 ID:SGTC_362|Compound:0310-0100|FD-Score:4.66|P-value:8.16E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.04|P-value:1.62E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.09|P-value:1.32E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:4.26|P-value:5.75E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:4.19|P-value:7.97E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-7.48|P-value:3.06E-15 ID:SGTC_788|Compound:1182-0090|FD-Score:4.45|P-value:2.34E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:5.18|P-value:4.68E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:5.05|P-value:9.64E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:3.13|P-value:6.72E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.04|P-value:7.16E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.28|P-value:3.88E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.32|P-value:3.28E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:5.27|P-value:2.85E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.84|P-value:2.13E-7 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.32|P-value:3.28E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.30|P-value:4.77E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.60|P-value:4.77E-12 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.68|P-value:7.67E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.12|P-value:6.87E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.78|P-value:3.72E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.32|P-value:4.43E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.04|P-value:9.12E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.74|P-value:6.02E-5 ID:SGTC_1695|Compound:st026914|FD-Score:4.33|P-value:4.27E-6 ID:SGTC_1707|Compound:st032323|FD-Score:4.40|P-value:2.91E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.97|P-value:2.25E-5 ID:SGTC_1711|Compound:st032263|FD-Score:4.52|P-value:1.66E-6 ID:SGTC_1762|Compound:st045503|FD-Score:3.58|P-value:1.20E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.57|P-value:9.08E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-3.57|P-value:8.97E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.03|P-value:1.71E-5 ID:SGTC_1943|Compound:st076331|FD-Score:7.75|P-value:5.87E-16 ID:SGTC_1953|Compound:st076800|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.26|P-value:4.14E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.71|P-value:6.92E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.05|P-value:8.82E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.12|P-value:1.14E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.02|P-value:9.86E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.98|P-value:2.12E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.22|P-value:4.81E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:9.27E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.96|P-value:9.26E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.07|P-value:1.88E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.59|P-value:1.13E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.65|P-value:8.90E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.70|P-value:7.27E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.11|P-value:1.21E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.02|P-value:9.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.30|P-value:2.71E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.97|P-value:1.54E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.87|P-value:2.48E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.49|P-value:1.28E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.63|P-value:6.44E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.97|P-value:1.60E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:5.22E-32 ID:SGTC_362|Compound:0310-0100|FD-Score:4.66|P-value:8.16E-7 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.04|P-value:1.62E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.09|P-value:1.32E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:4.26|P-value:5.75E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:4.19|P-value:7.97E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-7.48|P-value:3.06E-15 ID:SGTC_788|Compound:1182-0090|FD-Score:4.45|P-value:2.34E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:5.18|P-value:4.68E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:5.05|P-value:9.64E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:3.13|P-value:6.72E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.04|P-value:7.16E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.28|P-value:3.88E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.32|P-value:3.28E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:5.27|P-value:2.85E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.84|P-value:2.13E-7 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.32|P-value:3.28E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.30|P-value:4.77E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.60|P-value:4.77E-12 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.68|P-value:7.67E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.12|P-value:6.87E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.78|P-value:3.72E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.32|P-value:4.43E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.04|P-value:9.12E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.74|P-value:6.02E-5 ID:SGTC_1695|Compound:st026914|FD-Score:4.33|P-value:4.27E-6 ID:SGTC_1707|Compound:st032323|FD-Score:4.40|P-value:2.91E-6 ID:SGTC_1709|Compound:st033179|FD-Score:3.97|P-value:2.25E-5 ID:SGTC_1711|Compound:st032263|FD-Score:4.52|P-value:1.66E-6 ID:SGTC_1762|Compound:st045503|FD-Score:3.58|P-value:1.20E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.57|P-value:9.08E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-3.57|P-value:8.97E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.03|P-value:1.71E-5 ID:SGTC_1943|Compound:st076331|FD-Score:7.75|P-value:5.87E-16 ID:SGTC_1953|Compound:st076800|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.26|P-value:4.14E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.71|P-value:6.92E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.05|P-value:8.82E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.12|P-value:1.14E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.35|P-value:2.93E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.02|P-value:9.86E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.98|P-value:2.12E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.22|P-value:4.81E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:9.27E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.96|P-value:9.26E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:6.07|P-value:1.88E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.59|P-value:1.13E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.65|P-value:8.90E-5 ID:SGTC_2853|Compound:9015042|FD-Score:3.70|P-value:7.27E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.11|P-value:1.21E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.02|P-value:9.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.30|P-value:2.71E-4

Top fitness defect scores for YFR033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.30 5.3 µM 5.22E-32 165 4.85E-30
2 SGTC_1943 st076331 7.75 65.2 µM 5.87E-16 1 4.53E-15
3 SGTC_1368 1852-0141 6.60 284.0 µM 4.77E-12 ERG2 5 2.04E-11
4 SGTC_2756 carbadox 6.07 75.1 µM 1.88E-10 17 6.30E-10
5 SGTC_1185 1319-0113 5.27 81.3 µM 2.85E-8 DNA damage response 2 6.95E-8
6 SGTC_790 1575-0012 5.18 79.1 µM 4.68E-8 TSC3-RPN4 11 1.10E-7
7 SGTC_869 0564-0080 5.05 44.1 µM 9.64E-8 8 2.17E-7
8 SGTC_51 1013-0126 4.97 23.4 µM 1.54E-7 20 3.38E-7
9 SGTC_362 0310-0100 4.66 9.0 µM 8.16E-7 RPP1 & pyrimidine depletion 16 1.61E-6
10 SGTC_2757 clomiphene 4.59 4.2 µM 1.13E-6 fatty acid desaturase (OLE1) 24 2.18E-6
11 SGTC_1711 st032263 4.52 62.8 µM 1.66E-6 10 3.13E-6
12 SGTC_788 1182-0090 4.45 188.0 µM 2.34E-6 endomembrane recycling 65 4.32E-6
13 SGTC_1707 st032323 4.40 6.3 µM 2.91E-6 DNA damage response 46 5.31E-6
14 SGTC_1695 st026914 4.33 34.5 µM 4.27E-6 9 7.60E-6
15 SGTC_1635 st007035 4.32 42.4 µM 4.43E-6 194 7.87E-6
16 SGTC_1354 1498-1681 4.30 81.0 µM 4.77E-6 12 8.44E-6
17 SGTC_739 1486-1183 4.26 203.0 µM 5.75E-6 13 1.01E-5
18 SGTC_775 4577-0580 4.19 57.3 µM 7.97E-6 6 1.37E-5
19 SGTC_2178 5812956 4.12 200.0 µM 1.14E-5 11 1.92E-5
20 SGTC_2907 7721985 4.11 69.9 µM 1.21E-5 16 2.02E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.302 9.48E-72 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.298 9.37E-70 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.296 4.82E-69 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.288 5.43E-65 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.273 2.36E-58 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.267 1.21E-55 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.266 2.49E-55 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.265 6.24E-55 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.265 6.25E-55 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.263 3.90E-54 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.250 4.79E-49 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.246 2.83E-47 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.245 2.98E-47 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.243 3.27E-46 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.241 1.74E-45 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes