YFR035C_p

Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR035C / YFR035C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.53|P-value:2.35E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.19|P-value:7.83E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.18|P-value:6.37E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.24|P-value:5.16E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.47|P-value:3.13E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.15|P-value:1.39E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.29|P-value:4.31E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.33|P-value:3.66E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.24|P-value:5.14E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.46|P-value:2.29E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.12|P-value:1.55E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.28|P-value:5.76E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.83|P-value:5.31E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.23|P-value:9.62E-6 ID:SGTC_1736|Compound:st036774|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.27|P-value:4.64E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.08|P-value:8.92E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.81|P-value:2.40E-9 ID:SGTC_1945|Compound:st075991|FD-Score:-3.36|P-value:4.43E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.26|P-value:4.68E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2273|Compound:7815444|FD-Score:5.76|P-value:3.23E-9 ID:SGTC_2310|Compound:7668677|FD-Score:5.88|P-value:1.51E-9 ID:SGTC_2459|Compound:5811157|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.49|P-value:1.53E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.58|P-value:1.90E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.92|P-value:3.69E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.09|P-value:8.49E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.00|P-value:2.19E-7 ID:SGTC_2902|Compound:5787006|FD-Score:3.18|P-value:6.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.52|P-value:1.80E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.75|P-value:7.39E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.89|P-value:3.89E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:3.24E-4 ID:SGTC_3178|Compound:9107506|FD-Score:5.52|P-value:1.29E-8 ID:SGTC_3205|Compound:9113483|FD-Score:4.50|P-value:2.77E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.05|P-value:9.79E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.20|P-value:5.97E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.97|P-value:3.01E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-6.93|P-value:2.59E-12 ID:SGTC_3312|Compound:9133330|FD-Score:-6.13|P-value:5.23E-10 ID:SGTC_3326|Compound:9140064|FD-Score:11.60|P-value:6.86E-32 ID:SGTC_3330|Compound:9141424|FD-Score:5.54|P-value:1.18E-8 ID:SGTC_3332|Compound:9141069|FD-Score:-4.37|P-value:6.98E-6 ID:SGTC_3333|Compound:9141820|FD-Score:-4.34|P-value:8.21E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-5.08|P-value:2.23E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.53|P-value:2.35E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.19|P-value:7.83E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.18|P-value:6.37E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.24|P-value:5.16E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.47|P-value:3.13E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.15|P-value:1.39E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.29|P-value:4.31E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.33|P-value:3.66E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.24|P-value:5.14E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.46|P-value:2.29E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.12|P-value:1.55E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.28|P-value:5.76E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.83|P-value:5.31E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.23|P-value:9.62E-6 ID:SGTC_1736|Compound:st036774|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.27|P-value:4.64E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.08|P-value:8.92E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.81|P-value:2.40E-9 ID:SGTC_1945|Compound:st075991|FD-Score:-3.36|P-value:4.43E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.26|P-value:4.68E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2273|Compound:7815444|FD-Score:5.76|P-value:3.23E-9 ID:SGTC_2310|Compound:7668677|FD-Score:5.88|P-value:1.51E-9 ID:SGTC_2459|Compound:5811157|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.49|P-value:1.53E-8 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.58|P-value:1.90E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.92|P-value:3.69E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.09|P-value:8.49E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.00|P-value:2.19E-7 ID:SGTC_2902|Compound:5787006|FD-Score:3.18|P-value:6.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.52|P-value:1.80E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.75|P-value:7.39E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.89|P-value:3.89E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:3.24E-4 ID:SGTC_3178|Compound:9107506|FD-Score:5.52|P-value:1.29E-8 ID:SGTC_3205|Compound:9113483|FD-Score:4.50|P-value:2.77E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.05|P-value:9.79E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.20|P-value:5.97E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.97|P-value:3.01E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-6.93|P-value:2.59E-12 ID:SGTC_3312|Compound:9133330|FD-Score:-6.13|P-value:5.23E-10 ID:SGTC_3326|Compound:9140064|FD-Score:11.60|P-value:6.86E-32 ID:SGTC_3330|Compound:9141424|FD-Score:5.54|P-value:1.18E-8 ID:SGTC_3332|Compound:9141069|FD-Score:-4.37|P-value:6.98E-6 ID:SGTC_3333|Compound:9141820|FD-Score:-4.34|P-value:8.21E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-5.08|P-value:2.23E-7

Top fitness defect scores for YFR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3326 9140064 11.60 16.4 µM 6.86E-32 1 1.37E-31
2 SGTC_2310 7668677 5.88 200.0 µM 1.51E-9 6 2.04E-9
3 SGTC_1869 3',7'-dimethoxyflavone 5.81 40.3 µM 2.40E-9 3 3.21E-9
4 SGTC_2273 7815444 5.76 169.1 µM 3.23E-9 2 4.32E-9
5 SGTC_3330 9141424 5.54 71.4 µM 1.18E-8 amide catabolism 6 1.55E-8
6 SGTC_3178 9107506 5.52 49.5 µM 1.29E-8 1 1.70E-8
7 SGTC_2686 alizarin 5.49 95.4 µM 1.53E-8 RPP1 & pyrimidine depletion 13 2.01E-8
8 SGTC_2837 9008476 5.00 45.5 µM 2.19E-7 14 2.80E-7
9 SGTC_2959 9079155 4.89 11.0 µM 3.89E-7 13 4.94E-7
10 SGTC_2757 clomiphene 4.58 4.2 µM 1.90E-6 fatty acid desaturase (OLE1) 25 2.38E-6
11 SGTC_3205 9113483 4.50 49.5 µM 2.77E-6 15 3.45E-6
12 SGTC_632 0781-2353 4.47 4.7 µM 3.13E-6 Golgi 26 3.89E-6
13 SGTC_1629 st005085 4.23 44.9 µM 9.62E-6 RPP1 & pyrimidine depletion 28 1.18E-5
14 SGTC_902 1120-0002 4.15 2.1 µM 1.39E-5 azole & statin 42 1.70E-5
15 SGTC_1430 4049-0248 4.12 69.1 µM 1.55E-5 15 1.90E-5
16 SGTC_3260 9137109 3.97 49.5 µM 3.01E-5 60S ribosome export 11 3.64E-5
17 SGTC_2758 dehydroepiandrosterone 3.92 69.3 µM 3.69E-5 38 4.45E-5
18 SGTC_1514 1189-1591 3.83 158.0 µM 5.31E-5 38 6.39E-5
19 SGTC_3236 9132701 3.82 49.5 µM 5.53E-5 TSC3-RPN4 29 6.64E-5
20 SGTC_2958 9077254 3.75 16.7 µM 7.39E-5 37 8.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.48E-11 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.111 1.08E-10 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.102 2.68E-9 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.097 1.77E-8 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
0.086 5.55E-7 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.081 2.42E-6 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.081 2.50E-6 YCR095W-A_p YCR095W-A_p hom Putative protein of unknown function
0.081 2.96E-6 YOR358W HAP5 hom Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
0.079 4.84E-6 YPL200W CSM4 hom Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.077 9.04E-6 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.076 1.18E-5 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.075 1.38E-5 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.074 1.80E-5 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.072 3.14E-5 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.072 3.23E-5 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p