YFR036W / CDC26

Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR036W / CDC26

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:4.40|P-value:5.11E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:11.10|P-value:1.55E-23 ID:SGTC_148|Compound:3253-0744|FD-Score:8.41|P-value:3.26E-14 ID:SGTC_182|Compound:3448-4371|FD-Score:4.86|P-value:8.76E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:10.20|P-value:6.03E-20 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.36|P-value:5.95E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:3.55|P-value:8.97E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.58|P-value:8.32E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.48|P-value:5.93E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:4.16|P-value:1.22E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:5.86|P-value:1.01E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.68|P-value:1.77E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:5.04|P-value:4.16E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:5.02|P-value:4.43E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:4.77|P-value:1.24E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.56|P-value:8.69E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:7.18|P-value:8.51E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:4.50|P-value:3.54E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.12|P-value:2.83E-8 ID:SGTC_860|Compound:0443-0016|FD-Score:4.55|P-value:2.91E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:4.75|P-value:1.31E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:10.40|P-value:8.01E-21 ID:SGTC_883|Compound:0850-0245|FD-Score:5.03|P-value:4.35E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:9.27|P-value:6.57E-17 ID:SGTC_918|Compound:glabranin|FD-Score:4.09|P-value:1.56E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.04|P-value:1.87E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:5.82|P-value:1.23E-7 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.45|P-value:4.26E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.74|P-value:1.81E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.63|P-value:7.11E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.68|P-value:1.74E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.77|P-value:1.53E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.58|P-value:8.30E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.78|P-value:2.49E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.07|P-value:3.53E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.91|P-value:7.00E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:7.67|P-value:4.18E-12 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.12|P-value:1.40E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.71|P-value:5.45E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.08|P-value:3.45E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.23|P-value:1.81E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.49|P-value:3.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.85|P-value:8.97E-6 ID:SGTC_1682|Compound:st012968|FD-Score:5.16|P-value:2.41E-6 ID:SGTC_1711|Compound:st032263|FD-Score:5.74|P-value:1.77E-7 ID:SGTC_1738|Compound:st035555|FD-Score:5.17|P-value:2.36E-6 ID:SGTC_1755|Compound:st041960|FD-Score:10.10|P-value:1.06E-19 ID:SGTC_1763|Compound:st044482|FD-Score:3.53|P-value:9.68E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.15|P-value:1.26E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.54|P-value:9.35E-4 ID:SGTC_1777|Compound:st045864|FD-Score:5.07|P-value:3.57E-6 ID:SGTC_1815|Compound:st051655|FD-Score:3.82|P-value:3.86E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.81|P-value:1.07E-5 ID:SGTC_1831|Compound:st055328|FD-Score:6.32|P-value:1.02E-8 ID:SGTC_1845|Compound:st056753|FD-Score:5.46|P-value:6.40E-7 ID:SGTC_1861|Compound:st057647|FD-Score:-3.79|P-value:2.46E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.82|P-value:2.23E-4 ID:SGTC_1978|Compound:st071761|FD-Score:5.14|P-value:2.71E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.83|P-value:3.71E-4 ID:SGTC_1982|Compound:st072467|FD-Score:5.04|P-value:4.08E-6 ID:SGTC_2012|Compound:4023501|FD-Score:4.89|P-value:7.51E-6 ID:SGTC_2025|Compound:5147754|FD-Score:4.98|P-value:5.27E-6 ID:SGTC_2027|Compound:5150920|FD-Score:3.82|P-value:3.92E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.21|P-value:1.01E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.65|P-value:6.72E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.55|P-value:8.94E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.50|P-value:3.56E-5 ID:SGTC_2110|Compound:5483698|FD-Score:6.99|P-value:2.48E-10 ID:SGTC_2136|Compound:5328288|FD-Score:4.67|P-value:1.83E-5 ID:SGTC_2225|Compound:6654152|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.98|P-value:2.27E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.81|P-value:3.95E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.77|P-value:4.58E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:11.80|P-value:1.84E-26 ID:SGTC_2473|Compound:5854593|FD-Score:5.75|P-value:1.69E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.68|P-value:2.37E-7 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.84|P-value:9.29E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.66|P-value:6.44E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.37|P-value:9.31E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.14|P-value:2.63E-6 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:2.06E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.67|P-value:6.30E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.16|P-value:1.23E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.82|P-value:9.93E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:4.22|P-value:9.92E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.82|P-value:6.70E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.66|P-value:6.48E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.30|P-value:7.27E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.54|P-value:9.29E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.33|P-value:6.54E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.40|P-value:5.11E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:11.10|P-value:1.55E-23 ID:SGTC_148|Compound:3253-0744|FD-Score:8.41|P-value:3.26E-14 ID:SGTC_182|Compound:3448-4371|FD-Score:4.86|P-value:8.76E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:10.20|P-value:6.03E-20 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.36|P-value:5.95E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:3.55|P-value:8.97E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.58|P-value:8.32E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.48|P-value:5.93E-7 ID:SGTC_508|Compound:roscovitine|FD-Score:4.16|P-value:1.22E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:5.86|P-value:1.01E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.68|P-value:1.77E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:5.04|P-value:4.16E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:5.02|P-value:4.43E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:4.77|P-value:1.24E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.56|P-value:8.69E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:7.18|P-value:8.51E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:4.50|P-value:3.54E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.12|P-value:2.83E-8 ID:SGTC_860|Compound:0443-0016|FD-Score:4.55|P-value:2.91E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:4.75|P-value:1.31E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:10.40|P-value:8.01E-21 ID:SGTC_883|Compound:0850-0245|FD-Score:5.03|P-value:4.35E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:9.27|P-value:6.57E-17 ID:SGTC_918|Compound:glabranin|FD-Score:4.09|P-value:1.56E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.04|P-value:1.87E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:5.82|P-value:1.23E-7 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.45|P-value:4.26E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.74|P-value:1.81E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.63|P-value:7.11E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.68|P-value:1.74E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.77|P-value:1.53E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.58|P-value:8.30E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.78|P-value:2.49E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.07|P-value:3.53E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.91|P-value:7.00E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:7.67|P-value:4.18E-12 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.12|P-value:1.40E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.71|P-value:5.45E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.08|P-value:3.45E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.23|P-value:1.81E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.49|P-value:3.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.85|P-value:8.97E-6 ID:SGTC_1682|Compound:st012968|FD-Score:5.16|P-value:2.41E-6 ID:SGTC_1711|Compound:st032263|FD-Score:5.74|P-value:1.77E-7 ID:SGTC_1738|Compound:st035555|FD-Score:5.17|P-value:2.36E-6 ID:SGTC_1755|Compound:st041960|FD-Score:10.10|P-value:1.06E-19 ID:SGTC_1763|Compound:st044482|FD-Score:3.53|P-value:9.68E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.15|P-value:1.26E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.54|P-value:9.35E-4 ID:SGTC_1777|Compound:st045864|FD-Score:5.07|P-value:3.57E-6 ID:SGTC_1815|Compound:st051655|FD-Score:3.82|P-value:3.86E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.81|P-value:1.07E-5 ID:SGTC_1831|Compound:st055328|FD-Score:6.32|P-value:1.02E-8 ID:SGTC_1845|Compound:st056753|FD-Score:5.46|P-value:6.40E-7 ID:SGTC_1861|Compound:st057647|FD-Score:-3.79|P-value:2.46E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.82|P-value:2.23E-4 ID:SGTC_1978|Compound:st071761|FD-Score:5.14|P-value:2.71E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.83|P-value:3.71E-4 ID:SGTC_1982|Compound:st072467|FD-Score:5.04|P-value:4.08E-6 ID:SGTC_2012|Compound:4023501|FD-Score:4.89|P-value:7.51E-6 ID:SGTC_2025|Compound:5147754|FD-Score:4.98|P-value:5.27E-6 ID:SGTC_2027|Compound:5150920|FD-Score:3.82|P-value:3.92E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.21|P-value:1.01E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.65|P-value:6.72E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.55|P-value:8.94E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.50|P-value:3.56E-5 ID:SGTC_2110|Compound:5483698|FD-Score:6.99|P-value:2.48E-10 ID:SGTC_2136|Compound:5328288|FD-Score:4.67|P-value:1.83E-5 ID:SGTC_2225|Compound:6654152|FD-Score:4.15|P-value:1.25E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.98|P-value:2.27E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.81|P-value:3.95E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.77|P-value:4.58E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:11.80|P-value:1.84E-26 ID:SGTC_2473|Compound:5854593|FD-Score:5.75|P-value:1.69E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.68|P-value:2.37E-7 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.84|P-value:9.29E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.66|P-value:6.44E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.37|P-value:9.31E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.14|P-value:2.63E-6 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.01|P-value:2.06E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.67|P-value:6.30E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.16|P-value:1.23E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.82|P-value:9.93E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:4.22|P-value:9.92E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.82|P-value:6.70E-10 ID:SGTC_2927|Compound:9011802|FD-Score:3.66|P-value:6.48E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.30|P-value:7.27E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.54|P-value:9.29E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.33|P-value:6.54E-5

Top fitness defect scores for YFR036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 11.80 3.5 µM 1.84E-26 7 1.25E-32
2 SGTC_87 0100-0052 11.10 35.5 µM 1.55E-23 3 5.30E-29
3 SGTC_879 0831-1030 10.40 162.0 µM 8.01E-21 4 1.24E-25
4 SGTC_208 k072-0098 10.20 12.4 µM 6.03E-20 heme biosynthesis & mitochondrial translocase 2 1.52E-24
5 SGTC_1755 st041960 10.10 45.2 µM 1.06E-19 2 3.07E-24
6 SGTC_885 0865-0106 9.27 16.8 µM 6.57E-17 TSC3-RPN4 4 8.95E-21
7 SGTC_148 3253-0744 8.41 288.0 µM 3.26E-14 2 2.00E-17
8 SGTC_1336 1486-0901 7.67 104.0 µM 4.18E-12 1 8.29E-15
9 SGTC_806 3966-4455 7.18 5.9 µM 8.51E-11 3 3.51E-13
10 SGTC_2110 5483698 6.99 200.0 µM 2.48E-10 TSC3-RPN4 4 1.33E-12
11 SGTC_2788 5282734 6.82 71.4 µM 6.70E-10 6 4.57E-12
12 SGTC_1831 st055328 6.32 12.0 µM 1.02E-8 heme biosynthesis & mitochondrial translocase 3 1.34E-10
13 SGTC_832 4083-0019 6.12 164.0 µM 2.83E-8 translation 17 4.79E-10
14 SGTC_511 blebbistatin 5.86 171.0 µM 1.01E-7 DNA intercalators 4 2.33E-9
15 SGTC_964 1287-0107 5.82 19.4 µM 1.23E-7 cell wall 13 2.99E-9
16 SGTC_1125 tnp00248 5.77 1.3 µM 1.53E-7 5 3.91E-9
17 SGTC_2473 5854593 5.75 8.9 µM 1.69E-7 2 4.42E-9
18 SGTC_1711 st032263 5.74 62.8 µM 1.77E-7 6 4.70E-9
19 SGTC_1011 4112-3381 5.74 17.4 µM 1.81E-7 13 4.81E-9
20 SGTC_2498 4'-Methoxychalcone 5.68 54.6 µM 2.37E-7 RPP1 & pyrimidine depletion 7 6.75E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.44E-24 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.170 3.51E-23 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.160 8.85E-21 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.127 1.42E-13 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.126 2.59E-13 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.107 5.53E-10 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.100 6.04E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.098 1.50E-8 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.097 1.98E-8 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.095 4.18E-8 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.093 6.80E-8 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.092 9.21E-8 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.090 1.88E-7 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.089 2.09E-7 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.086 6.83E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1