HIPHOP chemogenomics database
YFR036W / CDC26 
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFR036W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.176 | 1.44E-24 | YOR282W_d | YOR282W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C |
| 0.170 | 3.51E-23 | YBR058C-A | TSC3 | hom | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
| 0.160 | 8.85E-21 | YER107C | GLE2 | hom | RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 |
| 0.127 | 1.42E-13 | YAL024C | LTE1 | hom | Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures |
| 0.126 | 2.59E-13 | YNL298W | CLA4 | hom | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p |
| 0.107 | 5.53E-10 | YJL111W | CCT7 | het | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
| 0.100 | 6.04E-9 | YER074W | RPS24A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication |
| 0.098 | 1.50E-8 | YNL134C | YNL134C | hom | Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress |
| 0.097 | 1.98E-8 | YCR001W_d | YCR001W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene |
| 0.095 | 4.18E-8 | YOR295W | UAF30 | hom | Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication |
| 0.093 | 6.80E-8 | YAR027W | UIP3 | hom | Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family |
| 0.092 | 9.21E-8 | YNL148C | ALF1 | hom | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |
| 0.090 | 1.88E-7 | YNL067W-B_p | YNL067W-B_p | hom | Putative protein of unknown function |
| 0.089 | 2.09E-7 | YDR527W | RBA50 | het | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
| 0.086 | 6.83E-7 | YPR085C | ASA1 | het | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |