YFR038W / IRC5

Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR038W / IRC5

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.30|P-value:2.47E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.55|P-value:3.94E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.84|P-value:2.62E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.68|P-value:4.25E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.07|P-value:9.16E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.49|P-value:4.76E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.05|P-value:1.04E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.12|P-value:5.07E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.89|P-value:1.20E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.35|P-value:7.45E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:3.41E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:9.37|P-value:1.04E-18 ID:SGTC_592|Compound:k241-0073|FD-Score:4.01|P-value:7.59E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.35|P-value:2.03E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:6.31|P-value:1.61E-9 ID:SGTC_861|Compound:0443-0273|FD-Score:5.02|P-value:1.18E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.63|P-value:6.55E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.59|P-value:1.44E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.43|P-value:1.49E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.33|P-value:2.18E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.54|P-value:4.09E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.92|P-value:1.81E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.45|P-value:5.45E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.41|P-value:1.61E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.95|P-value:1.63E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.09|P-value:5.66E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.94|P-value:9.98E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.41|P-value:9.97E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.93|P-value:1.03E-4 ID:SGTC_1605|Compound:st000082|FD-Score:6.90|P-value:5.21E-11 ID:SGTC_1609|Compound:st001574|FD-Score:-3.56|P-value:6.32E-4 ID:SGTC_1618|Compound:st003135|FD-Score:7.90|P-value:7.24E-14 ID:SGTC_1708|Compound:st033234|FD-Score:-3.66|P-value:4.59E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.13|P-value:4.88E-5 ID:SGTC_1778|Compound:st046819|FD-Score:5.00|P-value:1.28E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.30|P-value:8.68E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.04|P-value:6.77E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.35|P-value:2.08E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.39|P-value:6.55E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.41|P-value:6.19E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.35|P-value:2.09E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.09|P-value:5.55E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.70|P-value:2.35E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.86|P-value:1.33E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.69|P-value:5.06E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.99|P-value:8.14E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.35|P-value:2.06E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.86|P-value:2.40E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.05|P-value:6.56E-5 ID:SGTC_2839|Compound:9003951|FD-Score:-3.72|P-value:3.73E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.43|P-value:9.36E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.74|P-value:2.01E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.93|P-value:1.04E-4 ID:SGTC_2933|Compound:9026794|FD-Score:5.16|P-value:6.03E-7 ID:SGTC_3138|Compound:9097216|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.54|P-value:1.00E-7 ID:SGTC_11|Compound:0438-0307|FD-Score:4.30|P-value:2.47E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.55|P-value:3.94E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.84|P-value:2.62E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.68|P-value:4.25E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:5.07|P-value:9.16E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.49|P-value:4.76E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.05|P-value:1.04E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.12|P-value:5.07E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.89|P-value:1.20E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.35|P-value:7.45E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:3.41E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:9.37|P-value:1.04E-18 ID:SGTC_592|Compound:k241-0073|FD-Score:4.01|P-value:7.59E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.35|P-value:2.03E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:6.31|P-value:1.61E-9 ID:SGTC_861|Compound:0443-0273|FD-Score:5.02|P-value:1.18E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.63|P-value:6.55E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.59|P-value:1.44E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.43|P-value:1.49E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.33|P-value:2.18E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.54|P-value:4.09E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.92|P-value:1.81E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.45|P-value:5.45E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.41|P-value:1.61E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.95|P-value:1.63E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.09|P-value:5.66E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.94|P-value:9.98E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.41|P-value:9.97E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.93|P-value:1.03E-4 ID:SGTC_1605|Compound:st000082|FD-Score:6.90|P-value:5.21E-11 ID:SGTC_1609|Compound:st001574|FD-Score:-3.56|P-value:6.32E-4 ID:SGTC_1618|Compound:st003135|FD-Score:7.90|P-value:7.24E-14 ID:SGTC_1708|Compound:st033234|FD-Score:-3.66|P-value:4.59E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.13|P-value:4.88E-5 ID:SGTC_1778|Compound:st046819|FD-Score:5.00|P-value:1.28E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.30|P-value:8.68E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.04|P-value:6.77E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.35|P-value:2.08E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.39|P-value:6.55E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.41|P-value:6.19E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.35|P-value:2.09E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.09|P-value:5.55E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.70|P-value:2.35E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.86|P-value:1.33E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.69|P-value:5.06E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.99|P-value:8.14E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.35|P-value:2.06E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.86|P-value:2.40E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.05|P-value:6.56E-5 ID:SGTC_2839|Compound:9003951|FD-Score:-3.72|P-value:3.73E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.43|P-value:9.36E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.74|P-value:2.01E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.93|P-value:1.04E-4 ID:SGTC_2933|Compound:9026794|FD-Score:5.16|P-value:6.03E-7 ID:SGTC_3138|Compound:9097216|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.54|P-value:1.00E-7

Top fitness defect scores for YFR038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_588 3970-1144 9.37 52.9 µM 1.04E-18 1 3.58E-21
2 SGTC_1618 st003135 7.90 44.5 µM 7.24E-14 2 1.37E-15
3 SGTC_1605 st000082 6.90 49.1 µM 5.21E-11 60S ribosome export 1 2.66E-12
4 SGTC_777 1315-0167 6.31 517.0 µM 1.61E-9 Golgi 5 1.36E-10
5 SGTC_3146 9095609 5.54 49.5 µM 1.00E-7 3 1.56E-8
6 SGTC_2933 9026794 5.16 32.5 µM 6.03E-7 5 1.21E-7
7 SGTC_350 k064-0020 5.07 19.8 µM 9.16E-7 heme requiring 12 1.96E-7
8 SGTC_562 3772-2733 5.05 112.0 µM 1.04E-6 ERG2 51 2.25E-7
9 SGTC_861 0443-0273 5.02 110.0 µM 1.18E-6 2 2.60E-7
10 SGTC_1778 st046819 5.00 58.9 µM 1.28E-6 11 2.87E-7
11 SGTC_1112 tnp00069 4.95 1.2 µM 1.63E-6 10 3.77E-7
12 SGTC_1025 k007-0731 4.92 70.0 µM 1.81E-6 4 4.26E-7
13 SGTC_2712 st079126 4.86 47.7 µM 2.40E-6 2 5.88E-7
14 SGTC_60 0986-0278 4.84 202.0 µM 2.62E-6 2 6.51E-7
15 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.69 100.0 µM 5.06E-6 15 1.38E-6
16 SGTC_905 2-aminofluorene 4.63 215.0 µM 6.55E-6 cell wall signaling 17 1.85E-6
17 SGTC_915 methyl methanesulfonate (MMS) 4.43 110.0 mM 1.49E-5 DNA damage response 29 4.71E-6
18 SGTC_1085 doxorubicin 4.41 7.7 µM 1.61E-5 anthracycline transcription coupled DNA repair 10 5.16E-6
19 SGTC_1070 indatraline 4.40 8.8 µM 1.67E-5 60S ribosome export 15 5.38E-6
20 SGTC_612 0302-0167 4.35 22.4 µM 2.03E-5 copper-dependent oxidative stress 27 6.71E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.95E-12 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.095 3.75E-8 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.092 9.77E-8 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.085 7.06E-7 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.081 2.87E-6 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.079 5.16E-6 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.078 6.75E-6 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.073 2.10E-5 YCL059C KRR1 het Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
0.073 2.14E-5 YHR199C AIM46 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.073 2.58E-5 YOL070C NBA1 hom Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.072 3.03E-5 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.071 3.62E-5 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.070 4.81E-5 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
0.069 5.63E-5 YLR438W CAR2 hom L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
0.068 8.83E-5 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14