YFR040W / SAP155

Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR040W / SAP155

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:4.56E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.39|P-value:1.29E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:4.10|P-value:4.23E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:5.25|P-value:2.44E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.47|P-value:4.41E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.04|P-value:5.35E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.45|P-value:4.79E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.77|P-value:2.45E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.58|P-value:3.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.15|P-value:3.55E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.90|P-value:9.15E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:5.50|P-value:6.88E-8 ID:SGTC_1220|Compound:1838-0075|FD-Score:6.72|P-value:5.95E-11 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.44|P-value:4.83E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.11|P-value:4.02E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.72|P-value:1.80E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.98|P-value:6.95E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.68|P-value:2.13E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.79|P-value:1.42E-4 ID:SGTC_1737|Compound:st035557|FD-Score:5.49|P-value:7.26E-8 ID:SGTC_1781|Compound:st038725|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.93|P-value:8.21E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.28|P-value:8.50E-4 ID:SGTC_1994|Compound:st072947|FD-Score:5.92|P-value:6.92E-9 ID:SGTC_2007|Compound:4011539|FD-Score:3.95|P-value:7.74E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.37|P-value:1.32E-7 ID:SGTC_2078|Compound:5212016|FD-Score:4.17|P-value:3.29E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.96|P-value:7.47E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.30|P-value:7.80E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.44|P-value:4.96E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.14|P-value:3.57E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.52|P-value:7.37E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.33|P-value:1.64E-7 ID:SGTC_2678|Compound:equilin|FD-Score:4.15|P-value:3.50E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.78|P-value:1.50E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.25|P-value:9.15E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:7.03E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.75|P-value:1.64E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.06|P-value:6.21E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.38|P-value:5.98E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.49|P-value:4.14E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.30|P-value:1.87E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.15|P-value:3.95E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:4.56E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.39|P-value:1.29E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:4.10|P-value:4.23E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:5.25|P-value:2.44E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.47|P-value:4.41E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.04|P-value:5.35E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.45|P-value:4.79E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.77|P-value:2.45E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.58|P-value:3.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.15|P-value:3.55E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.90|P-value:9.15E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:5.50|P-value:6.88E-8 ID:SGTC_1220|Compound:1838-0075|FD-Score:6.72|P-value:5.95E-11 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.44|P-value:4.83E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.11|P-value:4.02E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.72|P-value:1.80E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.98|P-value:6.95E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.68|P-value:2.13E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.79|P-value:1.42E-4 ID:SGTC_1737|Compound:st035557|FD-Score:5.49|P-value:7.26E-8 ID:SGTC_1781|Compound:st038725|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.93|P-value:8.21E-5 ID:SGTC_1812|Compound:st052057|FD-Score:3.28|P-value:8.50E-4 ID:SGTC_1994|Compound:st072947|FD-Score:5.92|P-value:6.92E-9 ID:SGTC_2007|Compound:4011539|FD-Score:3.95|P-value:7.74E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.37|P-value:1.32E-7 ID:SGTC_2078|Compound:5212016|FD-Score:4.17|P-value:3.29E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.96|P-value:7.47E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.30|P-value:7.80E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.44|P-value:4.96E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.14|P-value:3.57E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.52|P-value:7.37E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.33|P-value:1.64E-7 ID:SGTC_2678|Compound:equilin|FD-Score:4.15|P-value:3.50E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.78|P-value:1.50E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.25|P-value:9.15E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:7.03E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.75|P-value:1.64E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.06|P-value:6.21E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.38|P-value:5.98E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.49|P-value:4.14E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.30|P-value:1.87E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.78|P-value:1.44E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.15|P-value:3.95E-7

Top fitness defect scores for YFR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1220 1838-0075 6.72 193.0 µM 5.95E-11 3 9.11E-12
2 SGTC_1994 st072947 5.92 40.9 µM 6.92E-9 2 1.59E-9
3 SGTC_2688 kanamycin b 5.78 96.7 µM 1.50E-8 calcium & mitochondrial duress 170 3.70E-9
4 SGTC_1217 1183-1422 5.50 255.0 µM 6.88E-8 2 1.93E-8
5 SGTC_1737 st035557 5.49 69.7 µM 7.26E-8 5 2.05E-8
6 SGTC_2009 4012297 5.37 12.1 µM 1.32E-7 cell wall signaling 31 3.92E-8
7 SGTC_2589 lobaric acid 5.33 100.0 µM 1.64E-7 8 4.95E-8
8 SGTC_312 4092-0653 5.25 6.8 µM 2.44E-7 ergosterol depletion effects on membrane 48 7.62E-8
9 SGTC_3159 9100096 5.15 49.5 µM 3.95E-7 7 1.29E-7
10 SGTC_2833 9001315 5.06 45.5 µM 6.21E-7 amide catabolism 29 2.10E-7
11 SGTC_1153 4055-0057 4.77 267.0 µM 2.45E-6 6 9.30E-7
12 SGTC_2582 agaric acid 4.52 100.0 µM 7.37E-6 redox potentiating 254 3.07E-6
13 SGTC_100 0086-0128 4.39 49.6 µM 1.29E-5 copper-dependent oxidative stress 33 5.67E-6
14 SGTC_3123 9126162 4.30 49.5 µM 1.87E-5 14 8.44E-6
15 SGTC_2078 5212016 4.17 200.0 µM 3.29E-5 60S ribosome export 12 1.56E-5
16 SGTC_2678 equilin 4.15 100.0 µM 3.50E-5 20 1.66E-5
17 SGTC_1183 1254-0324 4.15 198.0 µM 3.55E-5 17 1.69E-5
18 SGTC_2520 obtusaquinone 4.14 4.7 µM 3.57E-5 15 1.70E-5
19 SGTC_1510 1123-0200 4.11 71.5 µM 4.02E-5 38 1.94E-5
20 SGTC_233 rapamycin 4.10 362.0 pM 4.23E-5 8 2.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.86E-25 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.174 3.92E-24 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.140 3.91E-16 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.133 1.19E-14 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.123 1.03E-12 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.119 5.65E-12 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.103 2.05E-9 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.103 2.46E-9 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.103 2.49E-9 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.101 4.15E-9 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.101 4.53E-9 YOR216C RUD3 hom Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
0.100 6.73E-9 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.100 7.12E-9 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.098 1.35E-8 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.097 1.60E-8 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress