YFR043C / IRC6

Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR043C / IRC6

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.36|P-value:4.73E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.28|P-value:6.30E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.73|P-value:1.32E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.15|P-value:2.43E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:9.36E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.19|P-value:8.58E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.44|P-value:6.24E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:4.79|P-value:1.22E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.31|P-value:5.58E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.32|P-value:5.37E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.41|P-value:4.02E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.22|P-value:1.68E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.24|P-value:7.63E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.26|P-value:1.40E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.39|P-value:7.87E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.69|P-value:1.98E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.64|P-value:1.46E-8 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.22|P-value:1.69E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.14|P-value:2.32E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.22|P-value:8.07E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.87|P-value:4.05E-9 ID:SGTC_1724|Compound:st037281|FD-Score:7.46|P-value:1.16E-13 ID:SGTC_1762|Compound:st045503|FD-Score:-3.44|P-value:3.73E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.36|P-value:9.02E-6 ID:SGTC_1910|Compound:st062352|FD-Score:5.24|P-value:1.29E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.17|P-value:8.96E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.69|P-value:1.49E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.64|P-value:1.53E-8 ID:SGTC_2263|Compound:7948595|FD-Score:-4.74|P-value:1.69E-6 ID:SGTC_2265|Compound:7929201|FD-Score:4.89|P-value:7.55E-7 ID:SGTC_2275|Compound:7947463|FD-Score:4.47|P-value:5.61E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.01|P-value:3.96E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.14|P-value:9.96E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.94|P-value:5.44E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.03|P-value:3.66E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.85|P-value:7.61E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-4.36|P-value:9.93E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.52|P-value:4.80E-6 ID:SGTC_2806|Compound:7952793|FD-Score:5.53|P-value:2.72E-8 ID:SGTC_2808|Compound:7946468|FD-Score:6.72|P-value:2.00E-11 ID:SGTC_2838|Compound:9002687|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.47|P-value:3.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.00|P-value:4.23E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.89|P-value:7.82E-7 ID:SGTC_2995|Compound:9067767|FD-Score:-7.12|P-value:1.45E-12 ID:SGTC_3002|Compound:9075603|FD-Score:4.62|P-value:2.84E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.17|P-value:9.07E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.36|P-value:8.91E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.84|P-value:9.79E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.20|P-value:8.26E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.94|P-value:5.60E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.36|P-value:4.73E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.28|P-value:6.30E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.73|P-value:1.32E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.15|P-value:2.43E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.38|P-value:4.37E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.52|P-value:2.68E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.16|P-value:9.36E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.19|P-value:8.58E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.44|P-value:6.24E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:4.79|P-value:1.22E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.31|P-value:5.58E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.32|P-value:5.37E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.41|P-value:4.02E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.22|P-value:1.68E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.24|P-value:7.63E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.26|P-value:1.40E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.39|P-value:7.87E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:4.69|P-value:1.98E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.64|P-value:1.46E-8 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.22|P-value:1.69E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.14|P-value:2.32E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.22|P-value:8.07E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.87|P-value:4.05E-9 ID:SGTC_1724|Compound:st037281|FD-Score:7.46|P-value:1.16E-13 ID:SGTC_1762|Compound:st045503|FD-Score:-3.44|P-value:3.73E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.36|P-value:9.02E-6 ID:SGTC_1910|Compound:st062352|FD-Score:5.24|P-value:1.29E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.17|P-value:8.96E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.69|P-value:1.49E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.64|P-value:1.53E-8 ID:SGTC_2263|Compound:7948595|FD-Score:-4.74|P-value:1.69E-6 ID:SGTC_2265|Compound:7929201|FD-Score:4.89|P-value:7.55E-7 ID:SGTC_2275|Compound:7947463|FD-Score:4.47|P-value:5.61E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.01|P-value:3.96E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.14|P-value:9.96E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.94|P-value:5.44E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.03|P-value:3.66E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.85|P-value:7.61E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-4.36|P-value:9.93E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.52|P-value:4.80E-6 ID:SGTC_2806|Compound:7952793|FD-Score:5.53|P-value:2.72E-8 ID:SGTC_2808|Compound:7946468|FD-Score:6.72|P-value:2.00E-11 ID:SGTC_2838|Compound:9002687|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.47|P-value:3.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.00|P-value:4.23E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.89|P-value:7.82E-7 ID:SGTC_2995|Compound:9067767|FD-Score:-7.12|P-value:1.45E-12 ID:SGTC_3002|Compound:9075603|FD-Score:4.62|P-value:2.84E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.17|P-value:9.07E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.36|P-value:8.91E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.84|P-value:9.79E-7 ID:SGTC_3316|Compound:9136639|FD-Score:3.20|P-value:8.26E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.94|P-value:5.60E-5

Top fitness defect scores for YFR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1724 st037281 7.46 8.3 µM 1.16E-13 5 4.34E-14
2 SGTC_2808 7946468 6.72 45.5 µM 2.00E-11 3 9.00E-12
3 SGTC_1717 st033143 5.87 58.0 µM 4.05E-9 12 2.21E-9
4 SGTC_1221 2958-7315 5.64 257.0 µM 1.46E-8 3 8.34E-9
5 SGTC_2242 6630449 5.64 61.3 µM 1.53E-8 Golgi 19 8.74E-9
6 SGTC_2806 7952793 5.53 58.4 µM 2.72E-8 7 1.59E-8
7 SGTC_1910 st062352 5.24 60.4 µM 1.29E-7 10 7.94E-8
8 SGTC_2265 7929201 4.89 200.0 µM 7.55E-7 10 4.96E-7
9 SGTC_2992 9074591 4.89 71.4 µM 7.82E-7 8 5.15E-7
10 SGTC_3216 9129716 4.84 49.5 µM 9.79E-7 RPP1 & pyrimidine depletion 12 6.49E-7
11 SGTC_820 1582-0060 4.79 59.9 µM 1.22E-6 14 8.13E-7
12 SGTC_1218 1348-1416 4.69 30.7 µM 1.98E-6 SWF1 & branched chain AA biosynthesis 6 1.34E-6
13 SGTC_3002 9075603 4.62 71.4 µM 2.84E-6 8 1.96E-6
14 SGTC_2275 7947463 4.47 200.0 µM 5.61E-6 iron homeostasis 29 3.96E-6
15 SGTC_632 0781-2353 4.44 4.7 µM 6.24E-6 Golgi 27 4.42E-6
16 SGTC_1199 1638-0010 4.39 4.5 µM 7.87E-6 endomembrane recycling 10 5.62E-6
17 SGTC_3037 9091026 4.36 49.5 µM 8.91E-6 NEO1-PIK1 99 6.39E-6
18 SGTC_1900 st060200 4.36 72.8 µM 9.02E-6 16 6.47E-6
19 SGTC_1166 k206-0078 4.26 225.0 µM 1.40E-5 16 1.02E-5
20 SGTC_1114 scopoletin 4.22 1.7 µM 1.68E-5 17 1.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.93E-11 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.105 1.21E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.098 1.23E-8 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
0.096 2.62E-8 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.093 5.80E-8 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.093 6.29E-8 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.089 2.56E-7 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.085 7.57E-7 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.084 1.09E-6 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.083 1.31E-6 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.083 1.70E-6 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.080 3.65E-6 YER123W YCK3 hom Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
0.080 3.69E-6 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.080 3.65E-6 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.079 4.37E-6 YNL329C PEX6 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol