YFR044C / DUG1

Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR044C / DUG1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.54|P-value:3.02E-8 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.75|P-value:1.21E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.48|P-value:4.15E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.80|P-value:9.92E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.36|P-value:9.91E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.21|P-value:8.40E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.19|P-value:9.15E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.32|P-value:5.92E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.86|P-value:5.08E-9 ID:SGTC_820|Compound:1582-0060|FD-Score:3.98|P-value:5.01E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.85|P-value:8.37E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:4.04|P-value:3.83E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.52|P-value:2.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.27|P-value:6.93E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.94|P-value:5.69E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.12|P-value:2.75E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.99|P-value:4.67E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.93|P-value:6.00E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.56|P-value:2.48E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.95|P-value:6.50E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.45|P-value:3.70E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.70|P-value:2.09E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.23|P-value:7.97E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.44|P-value:5.02E-8 ID:SGTC_1919|Compound:st067113|FD-Score:3.82|P-value:9.26E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.32|P-value:5.74E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.68|P-value:1.62E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-3.97|P-value:5.07E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.19|P-value:2.03E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.85|P-value:8.24E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.79|P-value:1.39E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-5.10|P-value:2.97E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-5.70|P-value:1.27E-8 ID:SGTC_2396|Compound:5342950|FD-Score:-3.37|P-value:4.93E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.33|P-value:5.61E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:7.24|P-value:7.31E-13 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.83|P-value:9.02E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.23|P-value:1.73E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.30|P-value:6.29E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.19|P-value:9.11E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.85|P-value:8.35E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.60|P-value:2.14E-4 ID:SGTC_2844|Compound:9010103|FD-Score:6.55|P-value:7.35E-11 ID:SGTC_2980|Compound:9014342|FD-Score:-4.38|P-value:9.25E-6 ID:SGTC_2981|Compound:9013952|FD-Score:4.57|P-value:3.87E-6 ID:SGTC_3193|Compound:9111931|FD-Score:3.19|P-value:8.95E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.44|P-value:3.78E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.55|P-value:2.60E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.49|P-value:5.63E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.54|P-value:3.02E-8 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.75|P-value:1.21E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.48|P-value:4.15E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.80|P-value:9.92E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.36|P-value:9.91E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.21|P-value:8.40E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.19|P-value:9.15E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.32|P-value:5.92E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.86|P-value:5.08E-9 ID:SGTC_820|Compound:1582-0060|FD-Score:3.98|P-value:5.01E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.85|P-value:8.37E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:4.04|P-value:3.83E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.52|P-value:2.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.27|P-value:6.93E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.94|P-value:5.69E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.12|P-value:2.75E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.99|P-value:4.67E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.93|P-value:6.00E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.56|P-value:2.48E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.95|P-value:6.50E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.45|P-value:3.70E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.70|P-value:2.09E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.23|P-value:7.97E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.44|P-value:5.02E-8 ID:SGTC_1919|Compound:st067113|FD-Score:3.82|P-value:9.26E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.32|P-value:5.74E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.68|P-value:1.62E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-3.97|P-value:5.07E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.19|P-value:2.03E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.85|P-value:8.24E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.79|P-value:1.39E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-5.10|P-value:2.97E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-5.70|P-value:1.27E-8 ID:SGTC_2396|Compound:5342950|FD-Score:-3.37|P-value:4.93E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.33|P-value:5.61E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:7.24|P-value:7.31E-13 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.83|P-value:9.02E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.23|P-value:1.73E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.30|P-value:6.29E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.19|P-value:9.11E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.85|P-value:8.35E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.60|P-value:2.14E-4 ID:SGTC_2844|Compound:9010103|FD-Score:6.55|P-value:7.35E-11 ID:SGTC_2980|Compound:9014342|FD-Score:-4.38|P-value:9.25E-6 ID:SGTC_2981|Compound:9013952|FD-Score:4.57|P-value:3.87E-6 ID:SGTC_3193|Compound:9111931|FD-Score:3.19|P-value:8.95E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.44|P-value:3.78E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.55|P-value:2.60E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.49|P-value:5.63E-6

Top fitness defect scores for YFR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2543 pimpinellin 7.24 60.7 µM 7.31E-13 Golgi 1 2.32E-13
2 SGTC_2844 9010103 6.55 26.0 µM 7.35E-11 2 2.86E-11
3 SGTC_788 1182-0090 5.86 188.0 µM 5.08E-9 endomembrane recycling 38 2.38E-9
4 SGTC_58 0957-0393 5.54 9.0 µM 3.02E-8 cell wall 241 1.53E-8
5 SGTC_1847 st056231 5.44 15.0 µM 5.02E-8 10 2.60E-8
6 SGTC_691 1548-0686 5.30 185.0 µM 1.07E-7 8 5.70E-8
7 SGTC_1580 hydrocortisone 21-hemisuccinate 4.95 43.2 µM 6.50E-7 6 3.76E-7
8 SGTC_2289 7946404 4.79 165.1 µM 1.39E-6 63 8.29E-7
9 SGTC_1627 st003713 4.70 25.6 µM 2.09E-6 calcium & mitochondrial duress 48 1.27E-6
10 SGTC_2981 9013952 4.57 39.0 µM 3.87E-6 30 2.42E-6
11 SGTC_474 dl-dihydrosphingosine 4.36 5.0 µM 9.91E-6 18 6.45E-6
12 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.23 100.0 µM 1.73E-5 26 1.15E-5
13 SGTC_2265 7929201 4.19 200.0 µM 2.03E-5 18 1.37E-5
14 SGTC_1187 1391-0724 4.12 117.0 µM 2.75E-5 amide catabolism 15 1.87E-5
15 SGTC_866 0495-0101 4.04 262.0 µM 3.83E-5 60S ribosome export 17 2.64E-5
16 SGTC_1188 1403-0014 3.99 4.6 µM 4.67E-5 mitochondrial stress 51 3.25E-5
17 SGTC_820 1582-0060 3.98 59.9 µM 5.01E-5 30 3.50E-5
18 SGTC_1132 3456-3614 3.94 2.5 µM 5.69E-5 tubulin folding & SWR complex 45 3.99E-5
19 SGTC_1427 4048-4900 3.93 550.0 nM 6.00E-5 27 4.22E-5
20 SGTC_2267 7931562 3.85 200.0 µM 8.24E-5 21 5.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 5.92E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.117 1.18E-11 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.106 6.52E-10 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.104 1.40E-9 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.103 1.86E-9 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.101 3.95E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.100 6.54E-9 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.099 8.38E-9 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.097 1.61E-8 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.096 2.14E-8 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.096 2.66E-8 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.095 3.76E-8 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.093 7.38E-8 YCR098C GIT1 hom Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
0.090 1.76E-7 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.089 2.10E-7 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W