YFR045W_p

Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR045W / YFR045W

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-4.66|P-value:7.38E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:5.40E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:3.17|P-value:3.89E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.19|P-value:3.66E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.57|P-value:6.91E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.18|P-value:5.28E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.35|P-value:2.18E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.08|P-value:4.33E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.50|P-value:1.05E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.53|P-value:1.37E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.71|P-value:6.53E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.10|P-value:4.98E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.93|P-value:1.61E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.30|P-value:3.34E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.16|P-value:3.97E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.13|P-value:6.46E-4 ID:SGTC_1819|Compound:st053448|FD-Score:5.02|P-value:5.93E-8 ID:SGTC_1840|Compound:st055363|FD-Score:3.68|P-value:4.96E-5 ID:SGTC_1967|Compound:st070177|FD-Score:2.94|P-value:8.99E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.65|P-value:1.32E-9 ID:SGTC_2107|Compound:5363541|FD-Score:-3.16|P-value:5.85E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.34|P-value:2.05E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.71|P-value:8.18E-13 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.20|P-value:3.45E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.49|P-value:1.07E-6 ID:SGTC_2805|Compound:7950783|FD-Score:2.94|P-value:9.13E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.05|P-value:8.61E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.67|P-value:5.16E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.61|P-value:9.78E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.66|P-value:7.38E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:5.40E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:3.17|P-value:3.89E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.19|P-value:3.66E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.57|P-value:6.91E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.18|P-value:5.28E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.35|P-value:2.18E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.08|P-value:4.33E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.50|P-value:1.05E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.53|P-value:1.37E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.71|P-value:6.53E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.10|P-value:4.98E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.93|P-value:1.61E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.30|P-value:3.34E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.16|P-value:3.97E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.13|P-value:6.46E-4 ID:SGTC_1819|Compound:st053448|FD-Score:5.02|P-value:5.93E-8 ID:SGTC_1840|Compound:st055363|FD-Score:3.68|P-value:4.96E-5 ID:SGTC_1967|Compound:st070177|FD-Score:2.94|P-value:8.99E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.65|P-value:1.32E-9 ID:SGTC_2107|Compound:5363541|FD-Score:-3.16|P-value:5.85E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.34|P-value:2.05E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.71|P-value:8.18E-13 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.20|P-value:3.45E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.49|P-value:1.07E-6 ID:SGTC_2805|Compound:7950783|FD-Score:2.94|P-value:9.13E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.05|P-value:8.61E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.67|P-value:5.16E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.61|P-value:9.78E-5

Top fitness defect scores for YFR045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2409 alverine citrate 6.71 64.0 µM 8.18E-13 18 9.47E-12
2 SGTC_2105 5350118 5.65 200.0 µM 1.32E-9 8 7.93E-9
3 SGTC_1003 4049-0218 5.08 100.0 µM 4.33E-8 6 1.92E-7
4 SGTC_1819 st053448 5.02 58.6 µM 5.93E-8 amide catabolism 6 2.55E-7
5 SGTC_929 2805-0021 4.57 398.0 µM 6.91E-7 7 2.39E-6
6 SGTC_2802 7925815 4.49 54.5 µM 1.07E-6 28 3.55E-6
7 SGTC_1000 4048-0884 4.35 8.7 µM 2.18E-6 copper-dependent oxidative stress 25 6.79E-6
8 SGTC_1184 1269-1718 3.93 139.0 µM 1.61E-5 28 4.19E-5
9 SGTC_1840 st055363 3.68 71.0 µM 4.96E-5 17 1.17E-4
10 SGTC_2996 9066192 3.67 71.4 µM 5.16E-5 44 1.21E-4
11 SGTC_622 1348-1566 3.66 26.3 µM 5.40E-5 27 1.26E-4
12 SGTC_1007 4101-0031 3.50 70.0 µM 1.05E-4 31 2.31E-4
13 SGTC_2833 9001315 3.45 45.5 µM 1.27E-4 amide catabolism 76 2.76E-4
14 SGTC_2319 6033012 3.34 152.6 µM 2.05E-4 tubulin folding & SWR complex 47 4.26E-4
15 SGTC_2683 piperine 3.28 63.0 µM 2.55E-4 33 5.19E-4
16 SGTC_2520 obtusaquinone 3.20 4.7 µM 3.45E-4 45 6.84E-4
17 SGTC_853 0419-0306 3.19 21.0 µM 3.66E-4 40 7.21E-4
18 SGTC_2535 4',4'-dimethoxydalbergione 3.18 51.2 µM 3.75E-4 DNA damage response 38 7.37E-4
19 SGTC_698 k064-0052 3.17 127.0 µM 3.89E-4 DNA damage response 14 7.62E-4
20 SGTC_1719 st032227 3.16 49.2 µM 3.97E-4 55 7.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.30E-13 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.103 2.11E-9 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.103 2.49E-9 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.097 1.71E-8 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.095 4.05E-8 YMR086W SEG1 hom Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes
0.090 1.91E-7 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.089 2.17E-7 YPL025C_d YPL025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 4.82E-7 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.085 8.59E-7 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.085 9.24E-7 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.085 9.43E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.082 1.71E-6 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.082 2.08E-6 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.081 2.28E-6 YNL224C SQS1 hom Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
0.080 3.49E-6 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER