YFR046C / CNN1

Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR046C / CNN1

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.41|P-value:1.17E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.21|P-value:2.70E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.53|P-value:6.95E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:4.92|P-value:5.49E-8 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.16|P-value:3.19E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.78|P-value:2.27E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-4.71|P-value:1.82E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.20|P-value:2.93E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:2.99|P-value:6.25E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.08|P-value:5.41E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.34|P-value:1.56E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.95|P-value:1.02E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.37|P-value:1.35E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.92|P-value:1.17E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.96|P-value:6.99E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.28|P-value:1.97E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.75|P-value:2.57E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.08|P-value:5.24E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.15|P-value:3.31E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.05|P-value:4.92E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.50|P-value:8.01E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.08|P-value:4.45E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.19|P-value:2.88E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.12|P-value:3.86E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.88|P-value:9.41E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.41|P-value:2.60E-9 ID:SGTC_1719|Compound:st032227|FD-Score:-3.66|P-value:3.96E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-5.76|P-value:2.52E-10 ID:SGTC_1727|Compound:st034309|FD-Score:3.47|P-value:9.16E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.52|P-value:7.36E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.03|P-value:5.31E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.08|P-value:4.43E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.15|P-value:3.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.75|P-value:2.62E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-4.07|P-value:5.72E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.88|P-value:9.50E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.81|P-value:1.92E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.05|P-value:4.95E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.74|P-value:2.70E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.90|P-value:1.25E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.98|P-value:8.82E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.39|P-value:1.27E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.61|P-value:4.92E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.05|P-value:4.92E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.50|P-value:7.87E-5 ID:SGTC_2853|Compound:9015042|FD-Score:4.70|P-value:1.92E-7 ID:SGTC_2916|Compound:7875993|FD-Score:4.01|P-value:7.58E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-4.49|P-value:6.29E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.25|P-value:2.23E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.43|P-value:8.88E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.41|P-value:1.17E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.21|P-value:2.70E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.53|P-value:6.95E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:4.92|P-value:5.49E-8 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.16|P-value:3.19E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.78|P-value:2.27E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-4.71|P-value:1.82E-7 ID:SGTC_549|Compound:1661-1316|FD-Score:4.20|P-value:2.93E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:2.99|P-value:6.25E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.08|P-value:5.41E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.34|P-value:1.56E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.95|P-value:1.02E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.37|P-value:1.35E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.92|P-value:1.17E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.96|P-value:6.99E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.28|P-value:1.97E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.75|P-value:2.57E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.08|P-value:5.24E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.15|P-value:3.31E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.05|P-value:4.92E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.50|P-value:8.01E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.08|P-value:4.45E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.19|P-value:2.88E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.12|P-value:3.86E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.88|P-value:9.41E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.41|P-value:2.60E-9 ID:SGTC_1719|Compound:st032227|FD-Score:-3.66|P-value:3.96E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-5.76|P-value:2.52E-10 ID:SGTC_1727|Compound:st034309|FD-Score:3.47|P-value:9.16E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.52|P-value:7.36E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.03|P-value:5.31E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.08|P-value:4.43E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.15|P-value:3.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.75|P-value:2.62E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-4.07|P-value:5.72E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.88|P-value:9.50E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.81|P-value:1.92E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.05|P-value:4.95E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.74|P-value:2.70E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.90|P-value:1.25E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.98|P-value:8.82E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.39|P-value:1.27E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.61|P-value:4.92E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.05|P-value:4.92E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.50|P-value:7.87E-5 ID:SGTC_2853|Compound:9015042|FD-Score:4.70|P-value:1.92E-7 ID:SGTC_2916|Compound:7875993|FD-Score:4.01|P-value:7.58E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-4.49|P-value:6.29E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.25|P-value:2.23E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.43|P-value:8.88E-7

Top fitness defect scores for YFR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1633 st005664 5.41 67.9 µM 2.60E-9 11 3.13E-8
2 SGTC_428 3448-4153 4.92 16.5 µM 5.49E-8 TSC3-RPN4 15 4.34E-7
3 SGTC_2853 9015042 4.70 58.4 µM 1.92E-7 15 1.28E-6
4 SGTC_3307 9126885 4.43 69.3 µM 8.88E-7 23 4.79E-6
5 SGTC_549 1661-1316 4.20 519.0 µM 2.93E-6 13 1.35E-5
6 SGTC_730 1436-0052 4.08 41.2 µM 5.41E-6 mitochondrial processes 11 2.29E-5
7 SGTC_2916 7875993 4.01 68.8 µM 7.58E-6 26 3.06E-5
8 SGTC_2598 perillyl alcohol 3.98 100.0 µM 8.82E-6 31 3.48E-5
9 SGTC_906 1165-0455 3.95 526.0 µM 1.02E-5 12 3.94E-5
10 SGTC_1092 toremifene 3.75 6.3 µM 2.57E-5 23 8.80E-5
11 SGTC_2285 7945142 3.75 200.0 µM 2.62E-5 28 8.92E-5
12 SGTC_2489 cantharidin 3.74 73.4 µM 2.70E-5 cell wall signaling 50 9.17E-5
13 SGTC_2718 lomofungin 3.61 53.0 µM 4.92E-5 mitochondrial processes 17 1.54E-4
14 SGTC_424 splitomicin 3.53 100.0 mM 6.95E-5 30 2.08E-4
15 SGTC_1734 st037168 3.52 69.4 µM 7.36E-5 40 2.19E-4
16 SGTC_2851 9015922 3.50 71.4 µM 7.87E-5 60 2.32E-4
17 SGTC_1727 st034309 3.47 9.9 µM 9.16E-5 64 2.64E-4
18 SGTC_948 3448-0295 3.40 75.3 µM 1.22E-4 50 3.39E-4
19 SGTC_2621 lithochol-11-enic acid 3.39 100.0 µM 1.27E-4 51 3.50E-4
20 SGTC_950 1165-0508 3.37 94.1 µM 1.35E-4 46 3.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.18E-12 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.095 3.54E-8 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.092 9.68E-8 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.089 2.62E-7 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.088 3.01E-7 YMR023C MSS1 hom Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
0.085 7.99E-7 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.083 1.66E-6 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.082 2.16E-6 YFR053C HXK1 hom Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication
0.081 2.74E-6 YDR116C MRPL1 hom Mitochondrial ribosomal protein of the large subunit
0.079 4.43E-6 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.079 4.56E-6 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.077 7.13E-6 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.076 9.50E-6 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.075 1.27E-5 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.074 1.62E-5 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin