YFR047C / BNA6

Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR047C / BNA6

Click on Significant Values for Screen Details ID:SGTC_424|Compound:splitomicin|FD-Score:3.86|P-value:3.74E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.23|P-value:4.55E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.81|P-value:3.87E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.53|P-value:1.39E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.63|P-value:9.37E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.22|P-value:7.25E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:3.90|P-value:3.13E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.02|P-value:9.61E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.56|P-value:1.41E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:4.76|P-value:5.10E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.44|P-value:2.04E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.07|P-value:7.80E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.15|P-value:6.18E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.26|P-value:4.06E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.16|P-value:5.92E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.50|P-value:1.89E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.27|P-value:3.96E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-5.34|P-value:2.03E-8 ID:SGTC_3006|Compound:9075424|FD-Score:4.34|P-value:4.25E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:3.86|P-value:3.74E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.23|P-value:4.55E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.81|P-value:3.87E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.53|P-value:1.39E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.63|P-value:9.37E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.22|P-value:7.25E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:3.90|P-value:3.13E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.02|P-value:9.61E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.56|P-value:1.41E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:4.76|P-value:5.10E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.41|P-value:2.37E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.44|P-value:2.04E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.07|P-value:7.80E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.15|P-value:6.18E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.26|P-value:4.06E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.16|P-value:5.92E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.50|P-value:1.89E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.27|P-value:3.96E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-5.34|P-value:2.03E-8 ID:SGTC_3006|Compound:9075424|FD-Score:4.34|P-value:4.25E-6

Top fitness defect scores for YFR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_706 4262-0057 4.81 46.9 µM 3.87E-7 fatty acid desaturase (OLE1) 12 7.43E-7
2 SGTC_984 1492-0255 4.76 2.9 µM 5.10E-7 SWF1 & branched chain AA biosynthesis 20 9.65E-7
3 SGTC_983 1491-0821 4.56 12.2 µM 1.41E-6 5 2.53E-6
4 SGTC_2683 piperine 4.50 63.0 µM 1.89E-6 7 3.34E-6
5 SGTC_3006 9075424 4.34 71.4 µM 4.25E-6 9 7.22E-6
6 SGTC_736 0958-0254 4.22 92.6 µM 7.25E-6 Golgi 26 1.20E-5
7 SGTC_739 1486-1183 3.90 203.0 µM 3.13E-5 18 4.82E-5
8 SGTC_424 splitomicin 3.86 100.0 mM 3.74E-5 24 5.71E-5
9 SGTC_1150 3909-7983 3.50 10.9 µM 1.67E-4 42 2.37E-4
10 SGTC_1870 st057514 3.44 26.5 µM 2.04E-4 RSC & ERG11 41 2.86E-4
11 SGTC_1868 st057644 3.43 42.7 µM 2.13E-4 50 2.98E-4
12 SGTC_1317 1273-0028 3.41 910.0 nM 2.37E-4 azole & statin 71 3.30E-4
13 SGTC_2287 7945887 3.31 168.8 µM 3.41E-4 19 4.68E-4
14 SGTC_1878 temozolomide 3.27 1.0 mM 3.91E-4 24 5.31E-4
15 SGTC_2709 st078560 3.27 56.0 µM 3.94E-4 28 5.36E-4
16 SGTC_2713 st079149 3.27 53.4 µM 3.96E-4 47 5.38E-4
17 SGTC_2642 cholecalciferol 3.26 100.0 µM 4.06E-4 31 5.52E-4
18 SGTC_462 ag-879 3.23 158.0 µM 4.55E-4 62 6.14E-4
19 SGTC_2674 ligustilide 3.16 100.0 µM 5.92E-4 25 7.90E-4
20 SGTC_2615 purpurogallin-4-carboxylic acid 3.15 100.0 µM 6.18E-4 redox potentiating 108 8.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.87E-9 YHR098C SFB3 hom Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
0.100 6.10E-9 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.098 1.09E-8 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.083 1.33E-6 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.083 1.39E-6 YKR081C RPF2 het Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
0.082 1.77E-6 YJL103C GSM1 hom Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
0.081 2.28E-6 YNL224C SQS1 hom Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
0.081 2.75E-6 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.076 1.01E-5 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.072 3.07E-5 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.071 3.54E-5 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.071 4.04E-5 YHR096C HXT5 hom Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication
0.069 5.67E-5 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.069 6.31E-5 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
0.067 9.58E-5 YOL117W RRI2 hom Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response