YFR048W / RMD8

Cytosolic protein required for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR048W / RMD8

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.47|P-value:5.16E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.78|P-value:1.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.65|P-value:1.78E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:5.48|P-value:3.38E-8 ID:SGTC_136|Compound:0097-0015|FD-Score:3.59|P-value:1.99E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.31|P-value:5.33E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:7.73|P-value:1.36E-14 ID:SGTC_276|Compound:colchicine|FD-Score:4.60|P-value:2.92E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.47|P-value:3.44E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:5.41|P-value:4.86E-8 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.98|P-value:5.46E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.93|P-value:6.05E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.38|P-value:4.73E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.77|P-value:1.26E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.30|P-value:1.28E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:5.40|P-value:5.20E-8 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.33|P-value:5.69E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.70|P-value:1.46E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.29|P-value:6.51E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.49|P-value:3.17E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.35|P-value:6.80E-8 ID:SGTC_956|Compound:1185-0240|FD-Score:3.87|P-value:6.70E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.05|P-value:3.28E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.72|P-value:1.37E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.16|P-value:8.98E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.38|P-value:4.82E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.42|P-value:3.70E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.51|P-value:2.63E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.36|P-value:8.61E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.12|P-value:2.41E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.00|P-value:3.94E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.14|P-value:9.76E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.14|P-value:9.51E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.47|P-value:5.31E-6 ID:SGTC_1786|Compound:berberine|FD-Score:4.18|P-value:1.88E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.85|P-value:7.19E-5 ID:SGTC_2119|Compound:5528445|FD-Score:-3.27|P-value:6.87E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.90|P-value:3.16E-27 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:7.41E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.26|P-value:6.42E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.49|P-value:3.23E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.63|P-value:2.47E-6 ID:SGTC_2461|Compound:5755302|FD-Score:4.08|P-value:2.89E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.92|P-value:5.44E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.83|P-value:7.88E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.41|P-value:6.81E-6 ID:SGTC_2787|Compound:5284540|FD-Score:5.33|P-value:7.57E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-7.73|P-value:1.69E-14 ID:SGTC_3057|Compound:9095946|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.31|P-value:6.04E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.47|P-value:5.16E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.78|P-value:1.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.65|P-value:1.78E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:5.48|P-value:3.38E-8 ID:SGTC_136|Compound:0097-0015|FD-Score:3.59|P-value:1.99E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.31|P-value:5.33E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:7.73|P-value:1.36E-14 ID:SGTC_276|Compound:colchicine|FD-Score:4.60|P-value:2.92E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.47|P-value:3.44E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:5.41|P-value:4.86E-8 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.98|P-value:5.46E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.93|P-value:6.05E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.38|P-value:4.73E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.77|P-value:1.26E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.30|P-value:1.28E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:5.40|P-value:5.20E-8 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.33|P-value:5.69E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.70|P-value:1.46E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.29|P-value:6.51E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.49|P-value:3.17E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.35|P-value:6.80E-8 ID:SGTC_956|Compound:1185-0240|FD-Score:3.87|P-value:6.70E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.05|P-value:3.28E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.72|P-value:1.37E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.16|P-value:8.98E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.38|P-value:4.82E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.42|P-value:3.70E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.51|P-value:2.63E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.36|P-value:8.61E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.12|P-value:2.41E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.00|P-value:3.94E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.14|P-value:9.76E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.14|P-value:9.51E-4 ID:SGTC_1775|Compound:st081588|FD-Score:4.47|P-value:5.31E-6 ID:SGTC_1786|Compound:berberine|FD-Score:4.18|P-value:1.88E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.60|P-value:1.88E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.85|P-value:7.19E-5 ID:SGTC_2119|Compound:5528445|FD-Score:-3.27|P-value:6.87E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.90|P-value:3.16E-27 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:7.41E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.26|P-value:6.42E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.70|P-value:1.28E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.49|P-value:3.23E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.63|P-value:2.47E-6 ID:SGTC_2461|Compound:5755302|FD-Score:4.08|P-value:2.89E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.92|P-value:5.44E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.83|P-value:7.88E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.41|P-value:6.81E-6 ID:SGTC_2787|Compound:5284540|FD-Score:5.33|P-value:7.57E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-7.73|P-value:1.69E-14 ID:SGTC_3057|Compound:9095946|FD-Score:3.38|P-value:4.17E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-3.31|P-value:6.04E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.26|P-value:6.34E-4

Top fitness defect scores for YFR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2250 alverine citrate 10.90 130.0 µM 3.16E-27 5 4.63E-28
2 SGTC_176 1486-1328 7.73 72.8 µM 1.36E-14 13 5.36E-15
3 SGTC_62 0180-0423 5.48 3.2 µM 3.38E-8 60S ribosome export 7 2.15E-8
4 SGTC_312 4092-0653 5.47 6.8 µM 3.44E-8 ergosterol depletion effects on membrane 43 2.19E-8
5 SGTC_344 k064-0035 5.41 6.4 µM 4.86E-8 60S ribosome export 6 3.14E-8
6 SGTC_730 1436-0052 5.40 41.2 µM 5.20E-8 mitochondrial processes 1 3.36E-8
7 SGTC_950 1165-0508 5.35 94.1 µM 6.80E-8 9 4.43E-8
8 SGTC_2787 5284540 5.33 71.4 µM 7.57E-8 7 4.95E-8
9 SGTC_518 1021-0119 4.77 62.6 µM 1.26E-6 ERG2 17 9.03E-7
10 SGTC_2449 5812982 4.63 45.8 µM 2.47E-6 3 1.81E-6
11 SGTC_276 colchicine 4.60 750.0 µM 2.92E-6 8 2.14E-6
12 SGTC_6 0844-0013 4.47 19.8 µM 5.16E-6 54 3.85E-6
13 SGTC_1775 st081588 4.47 35.2 µM 5.31E-6 60S ribosome export 15 3.97E-6
14 SGTC_2782 7736369 4.41 71.4 µM 6.81E-6 27 5.14E-6
15 SGTC_1284 0929-0043 4.36 16.0 µM 8.61E-6 16 6.53E-6
16 SGTC_1337 1486-1011 4.26 40.3 µM 1.31E-5 11 1.01E-5
17 SGTC_1786 berberine 4.18 21.6 µM 1.88E-5 60S ribosome export 23 1.46E-5
18 SGTC_1380 2291-0730 4.12 164.0 µM 2.41E-5 20 1.89E-5
19 SGTC_2461 5755302 4.08 26.1 µM 2.89E-5 30 2.28E-5
20 SGTC_957 1187-1561 4.05 14.1 µM 3.28E-5 16 2.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 7.30E-24 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.169 7.77E-23 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.124 5.08E-13 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.122 1.18E-12 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.119 3.84E-12 YGR135W PRE9 hom Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
0.104 1.65E-9 YLR083C EMP70 hom Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments
0.102 3.36E-9 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.097 1.95E-8 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.093 6.37E-8 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.092 8.81E-8 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.091 1.15E-7 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.089 2.36E-7 YPR067W ISA2 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
0.086 5.57E-7 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.086 5.77E-7 YOR048C RAT1 het Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
0.085 8.02E-7 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1