YFR049W / YMR31

Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR049W / YMR31

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:4.03|P-value:7.47E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.65|P-value:3.02E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.51|P-value:4.91E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.71E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.48|P-value:1.24E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.34|P-value:8.51E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.41|P-value:6.72E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.64|P-value:6.16E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.20|P-value:3.87E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.89|P-value:1.98E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.61|P-value:6.92E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.33|P-value:8.93E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.07|P-value:4.67E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.85|P-value:2.39E-6 ID:SGTC_1744|Compound:st037937|FD-Score:-3.56|P-value:3.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.96|P-value:9.75E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.35|P-value:8.15E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.57|P-value:8.23E-6 ID:SGTC_1964|Compound:st076914|FD-Score:3.51|P-value:4.88E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.00|P-value:8.39E-5 ID:SGTC_2157|Compound:5649910|FD-Score:5.54|P-value:8.32E-8 ID:SGTC_2181|Compound:6316240|FD-Score:4.61|P-value:7.00E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.85|P-value:1.44E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.61|P-value:2.15E-10 ID:SGTC_2431|Compound:5490079|FD-Score:3.82|P-value:1.61E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.41|P-value:1.64E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.88|P-value:1.44E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.19|P-value:3.95E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.51|P-value:9.76E-8 ID:SGTC_2837|Compound:9008476|FD-Score:4.54|P-value:9.58E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.76|P-value:1.49E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.64|P-value:3.11E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.90|P-value:1.22E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.83|P-value:1.56E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.61|P-value:2.56E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.58|P-value:2.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.47|P-value:5.57E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.45|P-value:5.94E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.46|P-value:5.82E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.90|P-value:8.88E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.03|P-value:7.47E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.65|P-value:3.02E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.51|P-value:4.91E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.81|P-value:1.71E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.48|P-value:1.24E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.34|P-value:8.51E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.41|P-value:6.72E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.64|P-value:6.16E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.20|P-value:3.87E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.89|P-value:1.98E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.61|P-value:6.92E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.33|P-value:8.93E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.07|P-value:4.67E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.85|P-value:2.39E-6 ID:SGTC_1744|Compound:st037937|FD-Score:-3.56|P-value:3.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.96|P-value:9.75E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.35|P-value:8.15E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.57|P-value:8.23E-6 ID:SGTC_1964|Compound:st076914|FD-Score:3.51|P-value:4.88E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.00|P-value:8.39E-5 ID:SGTC_2157|Compound:5649910|FD-Score:5.54|P-value:8.32E-8 ID:SGTC_2181|Compound:6316240|FD-Score:4.61|P-value:7.00E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.85|P-value:1.44E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.61|P-value:2.15E-10 ID:SGTC_2431|Compound:5490079|FD-Score:3.82|P-value:1.61E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.41|P-value:1.64E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.88|P-value:1.44E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.19|P-value:3.95E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.51|P-value:9.76E-8 ID:SGTC_2837|Compound:9008476|FD-Score:4.54|P-value:9.58E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-3.76|P-value:1.49E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.64|P-value:3.11E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.90|P-value:1.22E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.83|P-value:1.56E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.61|P-value:2.56E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.58|P-value:2.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.47|P-value:5.57E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.45|P-value:5.94E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.46|P-value:5.82E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.90|P-value:8.88E-5

Top fitness defect scores for YFR049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2322 7413319 6.61 38.2 µM 2.15E-10 ERAD & cell cycle 54 1.98E-11
2 SGTC_2157 5649910 5.54 96.4 µM 8.32E-8 5 1.47E-8
3 SGTC_2688 kanamycin b 5.51 96.7 µM 9.76E-8 calcium & mitochondrial duress 194 1.76E-8
4 SGTC_1135 dihydrocapsaicin 4.89 536.7 nM 1.98E-6 14 4.98E-7
5 SGTC_1736 st036774 4.85 51.0 µM 2.39E-6 16 6.13E-7
6 SGTC_1075 aripiprazole 4.64 15.2 µM 6.16E-6 13 1.75E-6
7 SGTC_1417 3966-0327 4.61 90.4 µM 6.92E-6 8 1.99E-6
8 SGTC_2181 6316240 4.61 54.3 µM 7.00E-6 13 2.02E-6
9 SGTC_1923 st058458 4.57 19.1 µM 8.23E-6 19 2.42E-6
10 SGTC_2837 9008476 4.54 45.5 µM 9.58E-6 19 2.86E-6
11 SGTC_638 3970-0837 4.48 4.1 µM 1.24E-5 24 3.79E-6
12 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.41 66.7 µM 1.64E-5 9 5.20E-6
13 SGTC_1113 artemisinin 4.20 1.2 µM 3.87E-5 heme biosynthesis & mitochondrial translocase 10 1.35E-5
14 SGTC_2664 lyso-paf C-16 4.19 73.5 µM 3.95E-5 8 1.38E-5
15 SGTC_165 k038-0023 4.03 64.4 µM 7.47E-5 ubiquinone biosynthesis & proteasome 73 2.80E-5
16 SGTC_1999 st074831 4.00 12.5 µM 8.39E-5 plasma membrane duress 30 3.18E-5
17 SGTC_1754 st042065 3.96 16.1 µM 9.75E-5 NEO1-PIK1 178 3.76E-5
18 SGTC_3031 9088762 3.90 49.5 µM 1.22E-4 21 4.81E-5
19 SGTC_2250 alverine citrate 3.85 130.0 µM 1.44E-4 164 5.80E-5
20 SGTC_3037 9091026 3.83 49.5 µM 1.56E-4 NEO1-PIK1 129 6.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.92E-16 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.140 4.72E-16 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.135 5.16E-15 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.131 2.31E-14 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.128 1.11E-13 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.127 1.28E-13 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.124 5.37E-13 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.119 4.24E-12 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.119 5.06E-12 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.117 1.11E-11 YDR508C GNP1 hom High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication
0.116 1.86E-11 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication
0.114 3.10E-11 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.114 3.19E-11 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.114 3.22E-11 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.114 4.32E-11 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species