YFR051C / RET2

Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFR051C / RET2

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.64|P-value:6.55E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:11.20|P-value:9.42E-30 ID:SGTC_41|Compound:0478-0632|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.45|P-value:3.86E-11 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.36|P-value:3.62E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.19|P-value:6.55E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:6.35E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:8.62|P-value:1.87E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.66|P-value:1.35E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.98|P-value:2.61E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:4.86|P-value:4.78E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:3.78|P-value:6.86E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.83|P-value:5.61E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:6.16|P-value:2.72E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:5.94|P-value:1.04E-9 ID:SGTC_542|Compound:3381-0244|FD-Score:8.27|P-value:3.93E-17 ID:SGTC_562|Compound:3772-2733|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.59|P-value:1.48E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.89|P-value:4.12E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:6.48|P-value:3.29E-11 ID:SGTC_848|Compound:0368-0089|FD-Score:5.55|P-value:1.08E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.14|P-value:7.91E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.91|P-value:7.76E-16 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.99|P-value:2.95E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.46|P-value:2.47E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.80|P-value:6.46E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.11|P-value:8.51E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.15|P-value:1.43E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:12.20|P-value:7.29E-35 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.32|P-value:4.08E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.01|P-value:2.22E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:21.60|P-value:3.46E-105 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:8.08E-6 ID:SGTC_1711|Compound:st032263|FD-Score:-3.26|P-value:5.07E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.09|P-value:9.21E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.34|P-value:5.97E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.40|P-value:9.59E-42 ID:SGTC_1800|Compound:st050079|FD-Score:-3.42|P-value:2.82E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.37|P-value:3.46E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.21|P-value:6.03E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.59|P-value:1.83E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.96|P-value:3.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.72|P-value:1.00E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-3.31|P-value:4.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.22|P-value:1.76E-13 ID:SGTC_2038|Compound:4100038|FD-Score:7.31|P-value:8.92E-14 ID:SGTC_2041|Compound:5107442|FD-Score:4.28|P-value:8.14E-6 ID:SGTC_2086|Compound:5274770|FD-Score:-4.48|P-value:3.12E-6 ID:SGTC_2099|Compound:5377090|FD-Score:-3.60|P-value:1.42E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:36.60|P-value:5.53E-298 ID:SGTC_2402|Compound:5553605|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:4.02E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.35|P-value:3.67E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.31|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:4.57E-7 ID:SGTC_2698|Compound:st077697|FD-Score:3.17|P-value:7.02E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.02|P-value:2.53E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.43|P-value:2.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.85|P-value:5.14E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.34|P-value:3.83E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.25|P-value:5.22E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.29|P-value:4.63E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.15|P-value:7.50E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.44|P-value:2.63E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.37|P-value:3.44E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_3142|Compound:9086498|FD-Score:11.60|P-value:6.08E-32 ID:SGTC_3252|Compound:9135871|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.33|P-value:4.00E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:5.64|P-value:6.55E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:11.20|P-value:9.42E-30 ID:SGTC_41|Compound:0478-0632|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.45|P-value:3.86E-11 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.36|P-value:3.62E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.19|P-value:6.55E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:6.35E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:8.62|P-value:1.87E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.66|P-value:1.35E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.98|P-value:2.61E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:4.86|P-value:4.78E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:3.78|P-value:6.86E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.83|P-value:5.61E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:6.16|P-value:2.72E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:5.94|P-value:1.04E-9 ID:SGTC_542|Compound:3381-0244|FD-Score:8.27|P-value:3.93E-17 ID:SGTC_562|Compound:3772-2733|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.59|P-value:1.48E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.89|P-value:4.12E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:6.48|P-value:3.29E-11 ID:SGTC_848|Compound:0368-0089|FD-Score:5.55|P-value:1.08E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.14|P-value:7.91E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.91|P-value:7.76E-16 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.99|P-value:2.95E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.46|P-value:2.47E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.80|P-value:6.46E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.11|P-value:8.51E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.15|P-value:1.43E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:12.20|P-value:7.29E-35 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.32|P-value:4.08E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.01|P-value:2.22E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:21.60|P-value:3.46E-105 ID:SGTC_1687|Compound:st020778|FD-Score:4.28|P-value:8.08E-6 ID:SGTC_1711|Compound:st032263|FD-Score:-3.26|P-value:5.07E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.09|P-value:9.21E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.34|P-value:5.97E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.40|P-value:9.59E-42 ID:SGTC_1800|Compound:st050079|FD-Score:-3.42|P-value:2.82E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.37|P-value:3.46E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.21|P-value:6.03E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.59|P-value:1.83E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.96|P-value:3.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.72|P-value:1.00E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-3.31|P-value:4.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.22|P-value:1.76E-13 ID:SGTC_2038|Compound:4100038|FD-Score:7.31|P-value:8.92E-14 ID:SGTC_2041|Compound:5107442|FD-Score:4.28|P-value:8.14E-6 ID:SGTC_2086|Compound:5274770|FD-Score:-4.48|P-value:3.12E-6 ID:SGTC_2099|Compound:5377090|FD-Score:-3.60|P-value:1.42E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:36.60|P-value:5.53E-298 ID:SGTC_2402|Compound:5553605|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:4.02E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.35|P-value:3.67E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.31|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:4.57E-7 ID:SGTC_2698|Compound:st077697|FD-Score:3.17|P-value:7.02E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.02|P-value:2.53E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.43|P-value:2.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.85|P-value:5.14E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.34|P-value:3.83E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.25|P-value:5.22E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.29|P-value:4.63E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.15|P-value:7.50E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.44|P-value:2.63E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.37|P-value:3.44E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_3142|Compound:9086498|FD-Score:11.60|P-value:6.08E-32 ID:SGTC_3252|Compound:9135871|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.33|P-value:4.00E-4

Top fitness defect scores for YFR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2232 chlorophetanol 36.60 41.5 µM 5.53E-298 TRP & mitochondrial translation 1 2.11E-293 27.70
2 SGTC_1597 7-benzyloxygramine 21.60 47.5 µM 3.46E-105 calcium & mitochondrial duress 1 1.37E-103 2.63
3 SGTC_1789 tunicamycin 13.40 25.0 nM 9.59E-42 unfolded protein response 4 3.98E-41 4.44
4 SGTC_1306 1185-0270 12.20 9.0 µM 7.29E-35 Golgi 1 2.37E-34 3.92
5 SGTC_3142 9086498 11.60 49.5 µM 6.08E-32 iron homeostasis 6 1.78E-31 0.86
6 SGTC_22 0964-0034 11.20 14.5 µM 9.42E-30 unfolded protein response 2 2.55E-29 2.81
7 SGTC_255 tunicamycin 8.66 200.5 nM 1.35E-18 unfolded protein response 5 2.46E-18 0.31
8 SGTC_245 methotrexate 8.62 289.6 µM 1.87E-18 2 3.39E-18 1.43
9 SGTC_542 3381-0244 8.27 89.3 µM 3.93E-17 2 6.81E-17 1.16
10 SGTC_999 4022-0066 7.91 22.7 µM 7.76E-16 Golgi 2 1.29E-15 0.23
11 SGTC_2038 4100038 7.31 31.0 µM 8.92E-14 plasma membrane duress 2 1.37E-13 1.14
12 SGTC_2021 4019055 7.22 173.0 µM 1.76E-13 endomembrane recycling 13 2.68E-13 0.35
13 SGTC_763 3453-1109 6.48 128.0 µM 3.29E-11 1 4.63E-11 2.06
14 SGTC_103 0844-0104 6.45 51.8 µM 3.86E-11 ERAD & cell cycle 20 5.42E-11 0.04
15 SGTC_524 r073-0010 6.16 27.8 µM 2.72E-10 5 3.71E-10 0.66
16 SGTC_535 2293-4129 5.94 48.2 µM 1.04E-9 NEO1 3 1.38E-9 0.64
17 SGTC_3 0833-0587 5.64 95.6 µM 6.55E-9 redox potentiating 6 8.50E-9 0.76
18 SGTC_848 0368-0089 5.55 85.6 µM 1.08E-8 iron homeostasis 5 1.39E-8 1.00
19 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 5.01 54.9 µM 2.22E-7 redox potentiating 4 2.73E-7 0.90
20 SGTC_733 4069-0007 4.89 56.1 µM 4.12E-7 ERAD & cell cycle 13 5.02E-7 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.383 2.34E-117 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.326 5.99E-84 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.261 2.54E-53 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.191 7.37E-29 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.183 9.01E-27 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.177 6.15E-25 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.172 1.22E-23 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.163 1.77E-21 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.150 2.62E-18 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.150 3.19E-18 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.147 1.37E-17 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.143 9.72E-17 YER151C UBP3 hom Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.138 1.12E-15 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.134 7.63E-15 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.133 9.18E-15 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis