YFR054C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR054C / YFR054C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.33|P-value:2.70E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.73|P-value:5.34E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.37|P-value:1.55E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.40|P-value:2.17E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:9.56E-5 ID:SGTC_500|Compound:h-89|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:2.90|P-value:9.25E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.11|P-value:6.09E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.58|P-value:9.79E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.04|P-value:5.51E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:2.89|P-value:9.47E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.13|P-value:8.08E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.08|P-value:6.75E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.59|P-value:9.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.99|P-value:6.56E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.17|P-value:4.24E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.23|P-value:2.67E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.09|P-value:6.31E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.00|P-value:9.08E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:4.92E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.22|P-value:2.83E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.99|P-value:5.27E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.64|P-value:9.72E-10 ID:SGTC_1745|Compound:st081495|FD-Score:-3.24|P-value:3.70E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.24|P-value:3.71E-4 ID:SGTC_1767|Compound:st044992|FD-Score:2.91|P-value:8.95E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.35|P-value:5.96E-9 ID:SGTC_1843|Compound:st055809|FD-Score:-5.31|P-value:1.35E-8 ID:SGTC_1957|Compound:st077035|FD-Score:-3.17|P-value:4.88E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.69|P-value:6.08E-5 ID:SGTC_2019|Compound:4016004|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:2.93|P-value:8.40E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.51|P-value:8.40E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.75|P-value:4.58E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.55|P-value:7.11E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.69|P-value:7.04E-10 ID:SGTC_2643|Compound:anethole|FD-Score:-3.54|P-value:1.13E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.05|P-value:7.67E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:4.12|P-value:5.25E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.09|P-value:6.72E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.99|P-value:9.59E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.89|P-value:9.51E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.15|P-value:5.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-7.01|P-value:9.96E-14 ID:SGTC_2967|Compound:9089538|FD-Score:8.99|P-value:7.10E-22 ID:SGTC_2980|Compound:9014342|FD-Score:3.01|P-value:6.23E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.47|P-value:8.98E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.52|P-value:8.19E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.73|P-value:3.36E-5 ID:SGTC_3084|Compound:9116877|FD-Score:2.92|P-value:8.71E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.78|P-value:4.07E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.05|P-value:7.45E-6 ID:SGTC_3184|Compound:9108758|FD-Score:-3.13|P-value:5.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.33|P-value:2.70E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.73|P-value:5.34E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.37|P-value:1.55E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.40|P-value:2.17E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:9.56E-5 ID:SGTC_500|Compound:h-89|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:2.90|P-value:9.25E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.11|P-value:6.09E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.58|P-value:9.79E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.04|P-value:5.51E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:2.89|P-value:9.47E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-4.13|P-value:8.08E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-3.08|P-value:6.75E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.39|P-value:1.40E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.59|P-value:9.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.99|P-value:6.56E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.17|P-value:4.24E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.23|P-value:2.67E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.09|P-value:6.31E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.00|P-value:9.08E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:4.92E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.22|P-value:2.83E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.99|P-value:5.27E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.64|P-value:9.72E-10 ID:SGTC_1745|Compound:st081495|FD-Score:-3.24|P-value:3.70E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.24|P-value:3.71E-4 ID:SGTC_1767|Compound:st044992|FD-Score:2.91|P-value:8.95E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.35|P-value:5.96E-9 ID:SGTC_1843|Compound:st055809|FD-Score:-5.31|P-value:1.35E-8 ID:SGTC_1957|Compound:st077035|FD-Score:-3.17|P-value:4.88E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.69|P-value:6.08E-5 ID:SGTC_2019|Compound:4016004|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_2029|Compound:5175081|FD-Score:2.93|P-value:8.40E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.11|P-value:6.19E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.51|P-value:8.40E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.75|P-value:4.58E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.55|P-value:7.11E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.50|P-value:1.34E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.69|P-value:7.04E-10 ID:SGTC_2643|Compound:anethole|FD-Score:-3.54|P-value:1.13E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.05|P-value:7.67E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:4.12|P-value:5.25E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.09|P-value:6.72E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.99|P-value:9.59E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.89|P-value:9.51E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.15|P-value:5.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-7.01|P-value:9.96E-14 ID:SGTC_2967|Compound:9089538|FD-Score:8.99|P-value:7.10E-22 ID:SGTC_2980|Compound:9014342|FD-Score:3.01|P-value:6.23E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.47|P-value:8.98E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.52|P-value:8.19E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.73|P-value:3.36E-5 ID:SGTC_3084|Compound:9116877|FD-Score:2.92|P-value:8.71E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.78|P-value:4.07E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.05|P-value:7.45E-6 ID:SGTC_3184|Compound:9108758|FD-Score:-3.13|P-value:5.81E-4

Top fitness defect scores for YFR054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2967 9089538 8.99 49.9 µM 7.10E-22 2 1.27E-19
2 SGTC_39 0986-0283 5.73 58.4 µM 5.34E-10 calcium & mitochondrial duress 6 5.11E-9
3 SGTC_2616 abietic acid 5.69 100.0 µM 7.04E-10 12 6.53E-9
4 SGTC_1742 st038235 5.64 28.9 µM 9.72E-10 mitochondrial stress 57 8.71E-9
5 SGTC_1839 st053978 5.35 48.0 µM 5.96E-9 3 4.39E-8
6 SGTC_1735 st034310 4.99 56.8 µM 5.27E-8 Golgi 8 3.07E-7
7 SGTC_3013 9080133 4.47 71.4 µM 8.98E-7 11 3.85E-6
8 SGTC_41 0478-0632 4.37 82.6 µM 1.55E-6 21 6.27E-6
9 SGTC_1302 1159-0335 4.17 255.0 µM 4.24E-6 12 1.54E-5
10 SGTC_2773 thioridazine 4.12 9.1 µM 5.25E-6 7 1.86E-5
11 SGTC_1509 1326-1131 4.09 80.0 µM 6.31E-6 10 2.19E-5
12 SGTC_3149 9097855 4.05 49.5 µM 7.45E-6 Golgi 27 2.54E-5
13 SGTC_3075 9116269 3.73 49.5 µM 3.36E-5 26 9.71E-5
14 SGTC_1519 esterone 3.64 74.0 µM 4.92E-5 DNA intercalators 26 1.37E-4
15 SGTC_2607 solasodine 3.55 47.4 µM 7.11E-5 74 1.90E-4
16 SGTC_3043 9092303 3.52 49.5 µM 8.19E-5 31 2.15E-4
17 SGTC_2276 7947513 3.51 42.1 µM 8.40E-5 33 2.20E-4
18 SGTC_371 0195-0006 3.48 7.4 µM 9.56E-5 34 2.47E-4
19 SGTC_976 1348-1067 3.47 47.6 µM 1.01E-4 60S ribosome export 50 2.60E-4
20 SGTC_1091 telmisartan 3.39 47.6 µM 1.40E-4 36 3.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.23E-25 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.130 3.73E-14 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.129 7.66E-14 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.125 3.59E-13 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.112 7.73E-11 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.111 1.18E-10 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.108 3.37E-10 YPL090C RPS6A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
0.104 1.34E-9 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.095 3.74E-8 YDL130W-A STF1 hom Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress
0.095 4.04E-8 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.093 7.36E-8 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.092 1.12E-7 YMR001C CDC5 het Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
0.091 1.12E-7 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.089 2.52E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.087 4.79E-7 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication