YFR055W_p / IRC7

Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR055W / IRC7

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.80|P-value:2.21E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.34|P-value:8.19E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.70|P-value:2.00E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.80|P-value:2.19E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:4.66|P-value:4.25E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.37|P-value:1.47E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.37|P-value:6.10E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.95|P-value:7.71E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.73|P-value:2.20E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.47|P-value:1.20E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:5.92|P-value:7.80E-9 ID:SGTC_433|Compound:pimozide|FD-Score:-4.17|P-value:4.12E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.62|P-value:5.02E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.74|P-value:3.84E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:5.18|P-value:3.72E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.59|P-value:2.90E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.96|P-value:7.45E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.51|P-value:3.85E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.80|P-value:2.18E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.66|P-value:2.84E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.31|P-value:9.14E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.36|P-value:6.31E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.14|P-value:3.65E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.79|P-value:2.37E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.07|P-value:4.84E-5 ID:SGTC_1759|Compound:st043059|FD-Score:3.30|P-value:7.83E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.05|P-value:5.21E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.49|P-value:4.11E-4 ID:SGTC_1853|Compound:st056710|FD-Score:5.72|P-value:2.39E-8 ID:SGTC_1941|Compound:st076221|FD-Score:3.83|P-value:1.22E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.85|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.54|P-value:4.29E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.36|P-value:6.41E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.45|P-value:1.02E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.35|P-value:6.67E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.30|P-value:9.40E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.63|P-value:2.50E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.28|P-value:8.30E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.45|P-value:4.69E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.45|P-value:5.87E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.54|P-value:3.51E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.73|P-value:4.06E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-4.44|P-value:1.42E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.53|P-value:4.44E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.78|P-value:1.83E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.68|P-value:2.10E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.80|P-value:2.21E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.34|P-value:8.19E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.70|P-value:2.00E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.80|P-value:2.19E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:4.66|P-value:4.25E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.37|P-value:1.47E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.37|P-value:6.10E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.95|P-value:7.71E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.73|P-value:2.20E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.47|P-value:1.20E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:5.92|P-value:7.80E-9 ID:SGTC_433|Compound:pimozide|FD-Score:-4.17|P-value:4.12E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.62|P-value:5.02E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-4.74|P-value:3.84E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:5.18|P-value:3.72E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.59|P-value:2.90E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.96|P-value:7.45E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.51|P-value:3.85E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.80|P-value:2.18E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.66|P-value:2.84E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.31|P-value:9.14E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.36|P-value:6.31E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.14|P-value:3.65E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.79|P-value:2.37E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.07|P-value:4.84E-5 ID:SGTC_1759|Compound:st043059|FD-Score:3.30|P-value:7.83E-4 ID:SGTC_1806|Compound:st050005|FD-Score:4.05|P-value:5.21E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.49|P-value:4.11E-4 ID:SGTC_1853|Compound:st056710|FD-Score:5.72|P-value:2.39E-8 ID:SGTC_1941|Compound:st076221|FD-Score:3.83|P-value:1.22E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.85|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.54|P-value:4.29E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.36|P-value:6.41E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.45|P-value:1.02E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.35|P-value:6.67E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.30|P-value:9.40E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.63|P-value:2.50E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.28|P-value:8.30E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.45|P-value:4.69E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.45|P-value:5.87E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.54|P-value:3.51E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.73|P-value:4.06E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-4.44|P-value:1.42E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.53|P-value:4.44E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.78|P-value:1.83E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.68|P-value:2.10E-4

Top fitness defect scores for YFR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_429 1112-0049 5.92 25.5 µM 7.80E-9 DNA damage response 13 1.60E-9
2 SGTC_1853 st056710 5.72 91.2 µM 2.39E-8 amide catabolism 5 5.48E-9
3 SGTC_544 k015-0020 5.18 52.4 µM 3.72E-7 3 1.12E-7
4 SGTC_1082 camptothecin 4.80 424.9 nM 2.18E-6 DNA damage response 33 7.78E-7
5 SGTC_62 0180-0423 4.80 3.2 µM 2.19E-6 60S ribosome export 8 7.84E-7
6 SGTC_41 0478-0632 4.80 82.6 µM 2.21E-6 14 7.93E-7
7 SGTC_1533 dihydroergotamine mesylate 4.79 29.4 µM 2.37E-6 DNA intercalators 6 8.54E-7
8 SGTC_136 0097-0015 4.66 404.5 µM 4.25E-6 60S ribosome export 6 1.62E-6
9 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.62 8.0 µM 5.02E-6 16 1.94E-6
10 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.45 100.0 µM 1.02E-5 6 4.24E-6
11 SGTC_208 k072-0098 4.37 12.4 µM 1.47E-5 heme biosynthesis & mitochondrial translocase 32 6.32E-6
12 SGTC_1377 2944-0135 4.29 198.0 µM 2.04E-5 calcium & mitochondrial duress 29 9.06E-6
13 SGTC_1382 3002-2117 4.14 298.0 µM 3.65E-5 8 1.71E-5
14 SGTC_1737 st035557 4.07 69.7 µM 4.84E-5 16 2.33E-5
15 SGTC_1806 st050005 4.05 60.3 µM 5.21E-5 5 2.53E-5
16 SGTC_696 1560-0013 3.96 611.0 µM 7.45E-5 20 3.73E-5
17 SGTC_341 1486-1430 3.95 230.0 µM 7.71E-5 24 3.87E-5
18 SGTC_2105 5350118 3.85 200.0 µM 1.14E-4 30 5.97E-5
19 SGTC_1941 st076221 3.83 61.8 µM 1.22E-4 sphingolipid biosynthesis & PDR1 86 6.40E-5
20 SGTC_61 0978-8327 3.70 98.6 µM 2.00E-4 ergosterol biosynthesis 37 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.09E-11 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.096 2.67E-8 YCR022C_d YCR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
0.090 1.67E-7 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.090 1.91E-7 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.085 8.75E-7 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.084 1.02E-6 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.082 2.00E-6 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.082 2.06E-6 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.077 8.72E-6 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
0.076 1.09E-5 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
0.075 1.30E-5 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.075 1.40E-5 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.074 1.99E-5 YBR066C NRG2 hom Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication
0.073 2.18E-5 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.073 2.30E-5 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4