YFR056C_d

Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR056C / YFR056C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.33|P-value:2.86E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.65|P-value:8.20E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.46|P-value:1.98E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.09|P-value:6.99E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.78|P-value:4.13E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:5.44|P-value:9.28E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:10.50|P-value:6.76E-28 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.92|P-value:2.65E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.21|P-value:4.52E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.06|P-value:7.92E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.44|P-value:2.24E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:7.54E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.10|P-value:7.05E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.77|P-value:4.83E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.03|P-value:1.61E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.06|P-value:7.68E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.95|P-value:2.30E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.89|P-value:3.02E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.20|P-value:7.07E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.28|P-value:3.65E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.57|P-value:1.16E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.94|P-value:2.37E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.43|P-value:2.05E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.84|P-value:2.85E-7 ID:SGTC_1978|Compound:st071761|FD-Score:5.39|P-value:1.29E-8 ID:SGTC_1979|Compound:st071809|FD-Score:9.51|P-value:4.66E-23 ID:SGTC_1980|Compound:st071811|FD-Score:4.89|P-value:2.13E-7 ID:SGTC_1986|Compound:st071812|FD-Score:-3.49|P-value:1.63E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.17|P-value:5.20E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.84|P-value:2.91E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-4.75|P-value:4.85E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.32|P-value:2.99E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.23|P-value:4.13E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.67|P-value:7.76E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.74|P-value:5.52E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.06|P-value:8.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.10|P-value:6.75E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.70|P-value:1.97E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.57|P-value:1.12E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.69|P-value:6.42E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-4.27|P-value:5.28E-6 ID:SGTC_3205|Compound:9113483|FD-Score:5.73|P-value:1.59E-9 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:8.25E-4 ID:SGTC_3352|Compound:9151559|FD-Score:7.10|P-value:1.14E-13 ID:SGTC_6|Compound:0844-0013|FD-Score:3.33|P-value:2.86E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.65|P-value:8.20E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.46|P-value:1.98E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.09|P-value:6.99E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.78|P-value:4.13E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:5.44|P-value:9.28E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:10.50|P-value:6.76E-28 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.92|P-value:2.65E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.21|P-value:4.52E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.06|P-value:7.92E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.44|P-value:2.24E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:7.54E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.10|P-value:7.05E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.77|P-value:4.83E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.03|P-value:1.61E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.06|P-value:7.68E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.95|P-value:2.30E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.89|P-value:3.02E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.20|P-value:7.07E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.28|P-value:3.65E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.57|P-value:1.16E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.94|P-value:2.37E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.43|P-value:2.05E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.84|P-value:2.85E-7 ID:SGTC_1978|Compound:st071761|FD-Score:5.39|P-value:1.29E-8 ID:SGTC_1979|Compound:st071809|FD-Score:9.51|P-value:4.66E-23 ID:SGTC_1980|Compound:st071811|FD-Score:4.89|P-value:2.13E-7 ID:SGTC_1986|Compound:st071812|FD-Score:-3.49|P-value:1.63E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.17|P-value:5.20E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.84|P-value:2.91E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-4.75|P-value:4.85E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.32|P-value:2.99E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.23|P-value:4.13E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.67|P-value:7.76E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.74|P-value:5.52E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.06|P-value:8.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.10|P-value:6.75E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.70|P-value:1.97E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.57|P-value:1.12E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.69|P-value:6.42E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-4.27|P-value:5.28E-6 ID:SGTC_3205|Compound:9113483|FD-Score:5.73|P-value:1.59E-9 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:8.25E-4 ID:SGTC_3352|Compound:9151559|FD-Score:7.10|P-value:1.14E-13

Top fitness defect scores for YFR056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_516 3992-2719 10.50 87.3 µM 6.76E-28 1 2.86E-26
2 SGTC_1979 st071809 9.51 45.3 µM 4.66E-23 RPP1 & pyrimidine depletion 1 9.91E-22
3 SGTC_3352 9151559 7.10 45.6 µM 1.14E-13 1 6.42E-13
4 SGTC_3205 9113483 5.73 49.5 µM 1.59E-9 5 4.97E-9
5 SGTC_2571 chrysanthemic acid 5.70 100.0 µM 1.97E-9 3 6.09E-9
6 SGTC_515 4092-1064 5.44 102.0 µM 9.28E-9 plasma membrane duress 30 2.61E-8
7 SGTC_1978 st071761 5.39 42.0 µM 1.29E-8 TSC3-RPN4 6 3.55E-8
8 SGTC_1980 st071811 4.89 45.7 µM 2.13E-7 RPP1 & pyrimidine depletion 6 4.96E-7
9 SGTC_1977 st070720 4.84 65.3 µM 2.85E-7 2 6.50E-7
10 SGTC_1991 st073000 4.84 8.9 µM 2.91E-7 NEO1 53 6.63E-7
11 SGTC_2832 7992762 4.69 52.0 µM 6.42E-7 18 1.39E-6
12 SGTC_303 1348-1668 4.46 34.2 µM 1.98E-6 3 4.02E-6
13 SGTC_960 1222-0186 4.44 7.7 µM 2.24E-6 19 4.52E-6
14 SGTC_1465 k213-0056 4.20 144.0 µM 7.07E-6 DNA intercalators 18 1.33E-5
15 SGTC_972 1319-0219 4.19 195.0 µM 7.54E-6 21 1.41E-5
16 SGTC_1684 st024538 3.94 14.6 µM 2.37E-5 4 4.14E-5
17 SGTC_983 1491-0821 3.77 12.2 µM 4.83E-5 16 8.09E-5
18 SGTC_2279 7948423 3.74 32.9 µM 5.52E-5 17 9.18E-5
19 SGTC_75 0159-0059 3.65 199.0 µM 8.20E-5 fatty acid desaturase (OLE1) 27 1.33E-4
20 SGTC_2583 asiatic acid 3.57 100.0 µM 1.12E-4 47 1.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.19E-19 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.141 1.90E-16 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.141 2.47E-16 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.140 4.36E-16 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.127 1.59E-13 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.125 3.70E-13 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.124 4.85E-13 YDR037W KRS1 het Lysyl-tRNA synthetase
0.123 7.22E-13 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.121 1.90E-12 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.116 1.90E-11 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.116 1.97E-11 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.114 3.75E-11 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.111 9.77E-11 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.107 4.84E-10 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.106 6.61E-10 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies