YFR057W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR057W / YFR057W

Click on Significant Values for Screen Details ID:SGTC_300|Compound:r073-0011|FD-Score:3.75|P-value:1.63E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.28|P-value:8.41E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.74|P-value:1.67E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.25|P-value:2.32E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.53|P-value:3.52E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.54|P-value:3.04E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.51|P-value:3.86E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.44|P-value:4.92E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.24|P-value:9.46E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.94|P-value:1.04E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.65|P-value:2.31E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.33|P-value:7.14E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.83|P-value:1.18E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.23|P-value:2.08E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.57|P-value:3.10E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.75|P-value:1.63E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.28|P-value:8.41E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.74|P-value:1.67E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.25|P-value:2.32E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.53|P-value:3.52E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.54|P-value:3.04E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.51|P-value:3.86E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.44|P-value:4.92E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.24|P-value:9.46E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.94|P-value:1.04E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.65|P-value:2.31E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.33|P-value:7.14E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.83|P-value:1.18E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.23|P-value:2.08E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.57|P-value:3.10E-4

Top fitness defect scores for YFR057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2343 7990716 4.94 14.8 µM 1.04E-6 6 3.86E-7
2 SGTC_1378 2093-0007 4.25 380.0 nM 2.32E-5 16 1.09E-5
3 SGTC_1737 st035557 3.94 69.7 µM 8.01E-5 18 4.15E-5
4 SGTC_2695 st077686 3.83 52.0 µM 1.18E-4 40 6.32E-5
5 SGTC_300 r073-0011 3.75 5.0 µM 1.63E-4 25 8.91E-5
6 SGTC_1030 k029-0042 3.74 36.7 µM 1.67E-4 TSC3-RPN4 33 9.13E-5
7 SGTC_306 1672-3436 3.74 11.6 µM 1.69E-4 Golgi 19 9.30E-5
8 SGTC_2349 9023730 3.65 187.1 µM 2.31E-4 37 1.30E-4
9 SGTC_369 0957-0393 3.60 4.5 µM 2.82E-4 cell wall signaling 34 1.61E-4
10 SGTC_2857 9024691 3.57 58.4 µM 3.10E-4 35 1.78E-4
11 SGTC_1722 st034304 3.53 3.6 µM 3.52E-4 mitochondrial processes 45 2.04E-4
12 SGTC_1740 st038286 3.51 13.2 µM 3.86E-4 42 2.25E-4
13 SGTC_1816 st051957 3.44 91.6 µM 4.92E-4 19 2.93E-4
14 SGTC_2680 butyl paraben 3.33 22.2 µM 7.14E-4 amide catabolism 22 4.38E-4
15 SGTC_411 enrofloxacin 3.28 100.0 µM 8.41E-4 DNA damage response 24 5.22E-4
16 SGTC_2800 7887935 3.26 81.8 µM 8.94E-4 RPP1 & pyrimidine depletion 59 5.58E-4
17 SGTC_2144 5628481 3.24 200.0 µM 9.46E-4 ERG2 53 5.93E-4
18 SGTC_1852 st056254 3.22 31.4 µM 0.00103 33 6.50E-4
19 SGTC_301 4119-0100 3.19 24.5 µM 0.00113 NEO1 122 7.15E-4
20 SGTC_2051 5263410 3.13 176.0 µM 0.00138 43 8.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.28E-13 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
0.120 3.58E-12 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.114 3.86E-11 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.110 1.80E-10 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.094 4.51E-8 YKR005C_p YKR005C_p hom Putative protein of unknown function
0.092 9.54E-8 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.090 1.79E-7 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.086 5.90E-7 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.085 7.77E-7 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.083 1.51E-6 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.081 2.61E-6 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.080 3.75E-6 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.078 5.41E-6 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.076 1.03E-5 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.076 1.07E-5 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc