YGL003C / CDH1

Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL003C / CDH1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.29|P-value:2.09E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.42|P-value:5.36E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.95|P-value:7.94E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.21|P-value:2.84E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.11|P-value:4.68E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.26|P-value:9.70E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.92|P-value:8.79E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.83|P-value:1.25E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.12|P-value:4.14E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.96|P-value:7.57E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:3.91|P-value:9.05E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.74|P-value:1.89E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.32|P-value:7.81E-10 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.55|P-value:3.46E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.96|P-value:7.51E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.00|P-value:8.88E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.47|P-value:4.56E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.73|P-value:2.17E-8 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.80|P-value:2.27E-6 ID:SGTC_1687|Compound:st020778|FD-Score:-3.65|P-value:2.60E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.64|P-value:3.96E-8 ID:SGTC_1715|Compound:st032160|FD-Score:4.41|P-value:1.24E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.39|P-value:6.32E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.60|P-value:2.84E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.46|P-value:5.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.31|P-value:8.35E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.79|P-value:1.43E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.25|P-value:9.38E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.25|P-value:9.43E-4 ID:SGTC_2040|Compound:5100729|FD-Score:9.79|P-value:4.57E-21 ID:SGTC_2158|Compound:5657123|FD-Score:3.40|P-value:5.70E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.31|P-value:2.06E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:4.44|P-value:1.10E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.63|P-value:3.67E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.27|P-value:9.29E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.34|P-value:7.42E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.53|P-value:7.39E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.50|P-value:4.11E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.27|P-value:8.73E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.65|P-value:4.29E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.74|P-value:1.76E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.27|P-value:8.74E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.64|P-value:4.55E-6 ID:SGTC_3104|Compound:9120930|FD-Score:-3.48|P-value:4.63E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.25|P-value:9.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:5.55E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.29|P-value:2.09E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.42|P-value:5.36E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.95|P-value:7.94E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.21|P-value:2.84E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.11|P-value:4.68E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.39|P-value:5.98E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.26|P-value:9.70E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.92|P-value:8.79E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.83|P-value:1.25E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.12|P-value:4.14E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.96|P-value:7.57E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:3.91|P-value:9.05E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.74|P-value:1.89E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:6.32|P-value:7.81E-10 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.55|P-value:3.46E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.96|P-value:7.51E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.00|P-value:8.88E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.47|P-value:4.56E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.73|P-value:2.17E-8 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.80|P-value:2.27E-6 ID:SGTC_1687|Compound:st020778|FD-Score:-3.65|P-value:2.60E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.64|P-value:3.96E-8 ID:SGTC_1715|Compound:st032160|FD-Score:4.41|P-value:1.24E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.39|P-value:6.32E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.60|P-value:2.84E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.46|P-value:5.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.31|P-value:8.35E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.79|P-value:1.43E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.25|P-value:9.38E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.25|P-value:9.43E-4 ID:SGTC_2040|Compound:5100729|FD-Score:9.79|P-value:4.57E-21 ID:SGTC_2158|Compound:5657123|FD-Score:3.40|P-value:5.70E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.81|P-value:1.32E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.31|P-value:2.06E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:4.44|P-value:1.10E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.63|P-value:3.67E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.27|P-value:9.29E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.34|P-value:7.42E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.53|P-value:7.39E-6 ID:SGTC_2893|Compound:9048488|FD-Score:3.50|P-value:4.11E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.27|P-value:8.73E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.65|P-value:4.29E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.74|P-value:1.76E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.27|P-value:8.74E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.64|P-value:4.55E-6 ID:SGTC_3104|Compound:9120930|FD-Score:-3.48|P-value:4.63E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.25|P-value:9.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.41|P-value:5.55E-4

Top fitness defect scores for YGL003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2040 5100729 9.79 123.0 µM 4.57E-21 4 6.36E-23
2 SGTC_974 1326-0144 6.32 138.0 µM 7.81E-10 ERG2 9 1.31E-10
3 SGTC_1533 dihydroergotamine mesylate 5.73 29.4 µM 2.17E-8 DNA intercalators 3 5.00E-9
4 SGTC_2622 2-methoxyxanthone 5.63 59.9 µM 3.67E-8 6 8.87E-9
5 SGTC_1445 4239-0156 5.00 97.7 µM 8.88E-7 6 2.90E-7
6 SGTC_1551 6-bromo-3'-methylflavone 4.80 63.5 µM 2.27E-6 3 8.10E-7
7 SGTC_2970 9090938 4.65 41.9 µM 4.29E-6 RNA processing & uracil transport 19 1.62E-6
8 SGTC_3049 9092223 4.64 49.5 µM 4.55E-6 9 1.73E-6
9 SGTC_2860 9025725 4.53 39.0 µM 7.39E-6 RPP1 & pyrimidine depletion 4 2.94E-6
10 SGTC_2532 xanthone 4.44 78.9 µM 1.10E-5 19 4.55E-6
11 SGTC_1715 st032160 4.41 10.2 µM 1.24E-5 34 5.15E-6
12 SGTC_46 0329-0187a 4.29 2.2 µM 2.09E-5 58 9.13E-6
13 SGTC_259 usnic acid 4.21 108.9 µM 2.84E-5 12 1.28E-5
14 SGTC_784 4579-0127 4.12 173.0 µM 4.14E-5 18 1.93E-5
15 SGTC_1260 0700-1617 3.96 7.8 µM 7.51E-5 calcium & mitochondrial duress 29 3.70E-5
16 SGTC_786 4544-0069 3.96 423.0 µM 7.57E-5 25 3.73E-5
17 SGTC_230 MPP+ 3.95 141.7 µM 7.94E-5 14 3.93E-5
18 SGTC_682 0kpi-0099 3.92 17.0 µM 8.79E-5 71 4.39E-5
19 SGTC_914 3820-6779 3.91 408.0 µM 9.05E-5 24 4.53E-5
20 SGTC_780 0109-0199 3.83 192.0 µM 1.25E-4 16 6.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.29E-14 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.126 2.96E-13 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.111 1.24E-10 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.106 8.59E-10 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.103 2.35E-9 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.102 3.02E-9 YPR006C ICL2 hom 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
0.097 1.93E-8 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.096 2.75E-8 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.33E-7 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.087 5.15E-7 YCL059C KRR1 het Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
0.084 9.79E-7 YDR254W CHL4 hom Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15
0.081 3.05E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.080 3.52E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.078 6.18E-6 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.075 1.33E-5 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching