YGL005C / COG7

Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL005C / COG7

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:6.85|P-value:2.65E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:8.55|P-value:7.50E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:9.28|P-value:1.31E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:18.30|P-value:1.00E-20 ID:SGTC_70|Compound:0141-0289|FD-Score:9.52|P-value:7.10E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:7.24|P-value:1.23E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:10.50|P-value:4.83E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:10.50|P-value:5.07E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:6.33|P-value:6.80E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:12.30|P-value:2.13E-10 ID:SGTC_108|Compound:0509-0257|FD-Score:6.17|P-value:8.94E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:9.08|P-value:2.13E-6 ID:SGTC_389|Compound:tpck|FD-Score:13.60|P-value:3.15E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.71|P-value:3.40E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.39|P-value:9.07E-5 ID:SGTC_470|Compound:aa-861|FD-Score:7.49|P-value:7.49E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:7.14|P-value:1.50E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:6.52|P-value:4.85E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:7.55|P-value:6.68E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:10.10|P-value:1.42E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:19.90|P-value:3.98E-24 ID:SGTC_679|Compound:0422-0091|FD-Score:7.01|P-value:1.93E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:7.46|P-value:7.95E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:6.50|P-value:5.00E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:8.11|P-value:2.01E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:6.69|P-value:3.55E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.40|P-value:5.98E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:6.96|P-value:2.14E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:6.94|P-value:2.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:7.11|P-value:1.61E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:11.00|P-value:1.33E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:9.82|P-value:3.35E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:12.90|P-value:3.12E-11 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:9.95|P-value:2.35E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-10.00|P-value:1.86E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:13.40|P-value:6.89E-12 ID:SGTC_1084|Compound:voriconazole|FD-Score:-7.10|P-value:1.62E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:14.10|P-value:3.93E-13 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.22|P-value:8.22E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.86|P-value:2.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:12.50|P-value:1.37E-10 ID:SGTC_1306|Compound:1185-0270|FD-Score:22.50|P-value:2.16E-30 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.43|P-value:8.46E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:7.08|P-value:1.70E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:7.70|P-value:4.84E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:8.24|P-value:1.51E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-6.56|P-value:4.47E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:12.10|P-value:4.28E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:1.90E-9 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.27|P-value:1.17E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-6.30|P-value:7.07E-4 ID:SGTC_1775|Compound:st081588|FD-Score:8.75|P-value:4.70E-6 ID:SGTC_1790|Compound:st045711|FD-Score:8.84|P-value:3.86E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-6.11|P-value:9.78E-4 ID:SGTC_1837|Compound:st055472|FD-Score:6.48|P-value:5.22E-4 ID:SGTC_1985|Compound:st071382|FD-Score:6.83|P-value:2.73E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.65|P-value:3.79E-4 ID:SGTC_2041|Compound:5107442|FD-Score:9.85|P-value:3.09E-7 ID:SGTC_2059|Compound:5238311|FD-Score:8.40|P-value:1.05E-5 ID:SGTC_2063|Compound:5246145|FD-Score:7.38|P-value:9.38E-5 ID:SGTC_2194|Compound:5927483|FD-Score:8.15|P-value:1.83E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.63|P-value:3.95E-4 ID:SGTC_2242|Compound:6630449|FD-Score:7.98|P-value:2.70E-5 ID:SGTC_2268|Compound:7933382|FD-Score:9.24|P-value:1.46E-6 ID:SGTC_2269|Compound:7935389|FD-Score:7.83|P-value:3.72E-5 ID:SGTC_2271|Compound:7849410|FD-Score:6.70|P-value:3.45E-4 ID:SGTC_2277|Compound:7947813|FD-Score:7.50|P-value:7.31E-5 ID:SGTC_2435|Compound:5706476|FD-Score:6.63|P-value:3.98E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-6.13|P-value:9.48E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:8.84|P-value:3.85E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:6.23|P-value:8.00E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:6.75|P-value:3.14E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.74|P-value:3.23E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:7.21|P-value:1.31E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:7.68|P-value:5.01E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.58|P-value:7.00E-6 ID:SGTC_2671|Compound:danthron|FD-Score:7.22|P-value:1.29E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.30|P-value:7.10E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.00|P-value:2.98E-16 ID:SGTC_2766|Compound:oltipraz|FD-Score:11.60|P-value:1.84E-9 ID:SGTC_2770|Compound:toltrazuril|FD-Score:9.43|P-value:9.05E-7 ID:SGTC_2815|Compound:7968870|FD-Score:8.58|P-value:7.01E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-6.31|P-value:6.93E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-7.05|P-value:1.79E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-6.13|P-value:9.47E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.88|P-value:2.46E-4 ID:SGTC_3166|Compound:9102297|FD-Score:6.47|P-value:5.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:10.30|P-value:9.52E-8 ID:SGTC_1|Compound:0258-0098|FD-Score:6.85|P-value:2.65E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:8.55|P-value:7.50E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:9.28|P-value:1.31E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:18.30|P-value:1.00E-20 ID:SGTC_70|Compound:0141-0289|FD-Score:9.52|P-value:7.10E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:7.24|P-value:1.23E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:10.50|P-value:4.83E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:10.50|P-value:5.07E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:6.33|P-value:6.80E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:12.30|P-value:2.13E-10 ID:SGTC_108|Compound:0509-0257|FD-Score:6.17|P-value:8.94E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:9.08|P-value:2.13E-6 ID:SGTC_389|Compound:tpck|FD-Score:13.60|P-value:3.15E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.71|P-value:3.40E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.39|P-value:9.07E-5 ID:SGTC_470|Compound:aa-861|FD-Score:7.49|P-value:7.49E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:7.14|P-value:1.50E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:6.52|P-value:4.85E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:7.55|P-value:6.68E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:10.10|P-value:1.42E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:19.90|P-value:3.98E-24 ID:SGTC_679|Compound:0422-0091|FD-Score:7.01|P-value:1.93E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:7.46|P-value:7.95E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:6.50|P-value:5.00E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:8.11|P-value:2.01E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:6.69|P-value:3.55E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.40|P-value:5.98E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:6.96|P-value:2.14E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:6.94|P-value:2.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:7.11|P-value:1.61E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:11.00|P-value:1.33E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:9.82|P-value:3.35E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:12.90|P-value:3.12E-11 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:9.95|P-value:2.35E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-10.00|P-value:1.86E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:13.40|P-value:6.89E-12 ID:SGTC_1084|Compound:voriconazole|FD-Score:-7.10|P-value:1.62E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:14.10|P-value:3.93E-13 ID:SGTC_1241|Compound:0364-0022|FD-Score:6.22|P-value:8.22E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.86|P-value:2.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:12.50|P-value:1.37E-10 ID:SGTC_1306|Compound:1185-0270|FD-Score:22.50|P-value:2.16E-30 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.43|P-value:8.46E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:7.08|P-value:1.70E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:7.70|P-value:4.84E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:8.24|P-value:1.51E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-6.56|P-value:4.47E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:12.10|P-value:4.28E-10 ID:SGTC_1581|Compound:himbacine|FD-Score:11.60|P-value:1.90E-9 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.27|P-value:1.17E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-6.30|P-value:7.07E-4 ID:SGTC_1775|Compound:st081588|FD-Score:8.75|P-value:4.70E-6 ID:SGTC_1790|Compound:st045711|FD-Score:8.84|P-value:3.86E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-6.11|P-value:9.78E-4 ID:SGTC_1837|Compound:st055472|FD-Score:6.48|P-value:5.22E-4 ID:SGTC_1985|Compound:st071382|FD-Score:6.83|P-value:2.73E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.65|P-value:3.79E-4 ID:SGTC_2041|Compound:5107442|FD-Score:9.85|P-value:3.09E-7 ID:SGTC_2059|Compound:5238311|FD-Score:8.40|P-value:1.05E-5 ID:SGTC_2063|Compound:5246145|FD-Score:7.38|P-value:9.38E-5 ID:SGTC_2194|Compound:5927483|FD-Score:8.15|P-value:1.83E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.63|P-value:3.95E-4 ID:SGTC_2242|Compound:6630449|FD-Score:7.98|P-value:2.70E-5 ID:SGTC_2268|Compound:7933382|FD-Score:9.24|P-value:1.46E-6 ID:SGTC_2269|Compound:7935389|FD-Score:7.83|P-value:3.72E-5 ID:SGTC_2271|Compound:7849410|FD-Score:6.70|P-value:3.45E-4 ID:SGTC_2277|Compound:7947813|FD-Score:7.50|P-value:7.31E-5 ID:SGTC_2435|Compound:5706476|FD-Score:6.63|P-value:3.98E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-6.13|P-value:9.48E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:8.84|P-value:3.85E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:6.23|P-value:8.00E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:6.75|P-value:3.14E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.74|P-value:3.23E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:7.21|P-value:1.31E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:7.68|P-value:5.01E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.58|P-value:7.00E-6 ID:SGTC_2671|Compound:danthron|FD-Score:7.22|P-value:1.29E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.30|P-value:7.10E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.00|P-value:2.98E-16 ID:SGTC_2766|Compound:oltipraz|FD-Score:11.60|P-value:1.84E-9 ID:SGTC_2770|Compound:toltrazuril|FD-Score:9.43|P-value:9.05E-7 ID:SGTC_2815|Compound:7968870|FD-Score:8.58|P-value:7.01E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-6.31|P-value:6.93E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-7.05|P-value:1.79E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-6.13|P-value:9.47E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.88|P-value:2.46E-4 ID:SGTC_3166|Compound:9102297|FD-Score:6.47|P-value:5.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:10.30|P-value:9.52E-8

Top fitness defect scores for YGL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 22.50 9.0 µM 2.16E-30 Golgi 1 1.74E-112
2 SGTC_632 0781-2353 19.90 4.7 µM 3.98E-24 Golgi 1 3.31E-88
3 SGTC_22 0964-0034 18.30 14.5 µM 1.00E-20 unfolded protein response 3 4.81E-75
4 SGTC_2737 bleomycin 16.00 30.5 nM 2.98E-16 Golgi 5 9.09E-58
5 SGTC_1162 k048-0130 14.10 20.1 µM 3.93E-13 Golgi 1 9.55E-46
6 SGTC_389 tpck 13.60 16.7 µM 3.15E-12 2 2.86E-42
7 SGTC_1078 idebenone 13.40 36.1 µM 6.89E-12 Golgi 1 5.78E-41
8 SGTC_1068 loratadine 12.90 26.9 µM 3.12E-11 1 1.92E-38
9 SGTC_1250 0485-0349 12.50 40.2 µM 1.37E-10 1 5.53E-36
10 SGTC_98 0074-0023 12.30 107.7 µM 2.13E-10 Golgi 1 3.00E-35
11 SGTC_1525 8-methoxypsoralen 12.10 92.5 µM 4.28E-10 DNA damage response 1 4.36E-34
12 SGTC_2766 oltipraz 11.60 83.9 µM 1.84E-9 heme requiring 4 1.16E-31
13 SGTC_1581 himbacine 11.60 57.9 µM 1.90E-9 Golgi 3 1.32E-31
14 SGTC_999 4022-0066 11.00 22.7 µM 1.33E-8 Golgi 4 2.24E-28
15 SGTC_81 0411-0046 10.50 10.0 µM 4.83E-8 3 3.03E-26
16 SGTC_91 0417-1751 10.50 58.4 µM 5.07E-8 Golgi 5 3.63E-26
17 SGTC_3325 9138760 10.30 55.2 µM 9.52E-8 Golgi 4 4.00E-25
18 SGTC_624 k048-0052 10.10 28.0 µM 1.42E-7 Golgi 2 1.82E-24
19 SGTC_1069 diphenylcyclopropenone 9.95 8.5 µM 2.35E-7 1 1.25E-23
20 SGTC_2041 5107442 9.85 45.3 µM 3.09E-7 RSC complex & mRNA processing 3 3.54E-23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.609 0 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.528 2.24E-239 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.446 9.99E-163 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.370 3.71E-109 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.359 5.99E-102 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.309 5.26E-75 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.297 4.52E-69 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.297 5.07E-69 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.292 1.05E-66 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.275 7.09E-59 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.272 1.81E-57 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.271 2.65E-57 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.271 3.03E-57 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.222 1.53E-38 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.177 7.35E-25 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles