YGL007C-A_p

Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL007C-A / YGL007C-A

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.38|P-value:8.07E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.31|P-value:8.53E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.60|P-value:3.30E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.17|P-value:4.04E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.60|P-value:3.93E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.42|P-value:7.06E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.09|P-value:6.71E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.73|P-value:2.10E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.27|P-value:2.73E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.89|P-value:1.42E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.54|P-value:4.74E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.30|P-value:9.06E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.42|P-value:7.10E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.38|P-value:6.94E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.48|P-value:5.80E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.81|P-value:1.57E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.03|P-value:6.97E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.29|P-value:9.19E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.42|P-value:1.77E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.27|P-value:9.98E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.39|P-value:7.73E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.89|P-value:1.19E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:8.02E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.45|P-value:5.52E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.57|P-value:7.76E-6 ID:SGTC_2029|Compound:5175081|FD-Score:3.62|P-value:3.10E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.41|P-value:6.36E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.47|P-value:1.46E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.24|P-value:3.06E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.71|P-value:2.23E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_2703|Compound:st077852|FD-Score:4.54|P-value:8.84E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.70|P-value:2.30E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.61|P-value:3.77E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.38|P-value:8.07E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.31|P-value:8.53E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.41|P-value:7.30E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.60|P-value:3.30E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.17|P-value:4.04E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.60|P-value:3.93E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.42|P-value:7.06E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.03|P-value:7.01E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.09|P-value:6.71E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.73|P-value:2.10E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.27|P-value:2.73E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.89|P-value:1.42E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.54|P-value:4.74E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.30|P-value:9.06E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.42|P-value:7.10E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.38|P-value:6.94E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.48|P-value:5.80E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.81|P-value:1.57E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.03|P-value:6.97E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.29|P-value:9.19E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.54|P-value:4.02E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.42|P-value:1.77E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.27|P-value:9.98E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.39|P-value:7.73E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.89|P-value:1.19E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:8.02E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.45|P-value:5.52E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.57|P-value:7.76E-6 ID:SGTC_2029|Compound:5175081|FD-Score:3.62|P-value:3.10E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.41|P-value:6.36E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.47|P-value:1.46E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.24|P-value:3.06E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.71|P-value:2.23E-4 ID:SGTC_2694|Compound:st077685|FD-Score:4.06|P-value:6.18E-5 ID:SGTC_2703|Compound:st077852|FD-Score:4.54|P-value:8.84E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.70|P-value:2.30E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.61|P-value:3.77E-4

Top fitness defect scores for YGL007C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1922 5578187 4.57 25.0 µM 7.76E-6 TRP & mitochondrial translation 18 2.39E-6
2 SGTC_2703 st077852 4.54 53.4 µM 8.84E-6 10 2.76E-6
3 SGTC_1483 3453-0561 4.32 55.9 µM 2.19E-5 16 7.63E-6
4 SGTC_451 chloral hydrate 4.27 100.0 µM 2.73E-5 42 9.77E-6
5 SGTC_2403 6032726 4.24 181.2 µM 3.06E-5 34 1.11E-5
6 SGTC_122 0236-0016 4.17 402.4 µM 4.04E-5 RNA processing & uracil transport 27 1.52E-5
7 SGTC_2694 st077685 4.06 81.9 µM 6.18E-5 endomembrane recycling 27 2.44E-5
8 SGTC_1491 4138-0063 4.03 26.5 µM 6.97E-5 10 2.79E-5
9 SGTC_204 1543-0184 4.03 62.4 µM 7.01E-5 TRP & mitochondrial translation 29 2.81E-5
10 SGTC_1881 5652484 3.99 16.0 µM 8.02E-5 TRP & mitochondrial translation 28 3.27E-5
11 SGTC_1618 st003135 3.93 44.5 µM 1.01E-4 21 4.22E-5
12 SGTC_2459 5811157 3.89 9.2 µM 1.16E-4 mitochondrial processes 14 4.95E-5
13 SGTC_1876 myriocin 3.89 605.0 nM 1.19E-4 34 5.06E-5
14 SGTC_2916 7875993 3.87 68.8 µM 1.25E-4 31 5.38E-5
15 SGTC_2814 7977482 3.86 43.0 µM 1.32E-4 54 5.70E-5
16 SGTC_1468 k284-1086 3.81 134.0 µM 1.57E-4 DNA intercalators 43 6.92E-5
17 SGTC_1627 st003713 3.76 25.6 µM 1.86E-4 calcium & mitochondrial duress 85 8.36E-5
18 SGTC_387 norethindrone acetate 3.73 66.7 µM 2.10E-4 21 9.57E-5
19 SGTC_1601 4'-hydroxyflavanone 3.71 55.5 µM 2.21E-4 RPP1 & pyrimidine depletion 36 1.02E-4
20 SGTC_2507 purpurin 3.71 79.7 µM 2.23E-4 copper-dependent oxidative stress 49 1.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.12E-17 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.137 1.64E-15 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
0.126 2.62E-13 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.118 7.47E-12 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.099 1.03E-8 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.098 1.26E-8 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.097 2.06E-8 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.095 3.74E-8 YOR201C MRM1 hom Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
0.084 1.21E-6 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.080 3.11E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.079 5.18E-6 YLR325C RPL38 hom Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog
0.077 8.86E-6 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.076 1.15E-5 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.074 1.61E-5 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.074 1.95E-5 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)