YGL010W_p

Putative protein of unknown function; YGL010W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL010W / YGL010W

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:6.51|P-value:1.97E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.63|P-value:1.09E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.43|P-value:2.38E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.24|P-value:5.23E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.45|P-value:2.18E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.19|P-value:5.64E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.15|P-value:7.00E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.91|P-value:3.67E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.33|P-value:3.45E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.50|P-value:2.51E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:6.21|P-value:1.49E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:-5.08|P-value:1.16E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.89|P-value:3.97E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.07|P-value:9.51E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.32|P-value:3.60E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-4.04|P-value:1.93E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.51|P-value:2.39E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.73|P-value:8.03E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.31|P-value:3.94E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.90|P-value:3.85E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.92|P-value:3.61E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.24|P-value:4.84E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:-3.22|P-value:5.22E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.21|P-value:5.31E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-5.14|P-value:8.16E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.30|P-value:6.46E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.67|P-value:9.86E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.04|P-value:9.78E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.69|P-value:9.09E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.07|P-value:9.29E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.11|P-value:8.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.06|P-value:1.28E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.63|P-value:5.61E-9 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.94|P-value:2.95E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.34|P-value:3.54E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.47|P-value:2.88E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.61|P-value:1.28E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.62|P-value:1.39E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.42|P-value:1.97E-8 ID:SGTC_3068|Compound:9116768|FD-Score:4.80|P-value:5.67E-7 ID:SGTC_3076|Compound:9116187|FD-Score:-4.59|P-value:1.46E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.69|P-value:8.46E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-8.71|P-value:4.11E-19 ID:SGTC_3144|Compound:9087057|FD-Score:3.14|P-value:7.39E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.20|P-value:5.49E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.06|P-value:1.43E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.78|P-value:5.79E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:6.51|P-value:1.97E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.63|P-value:1.09E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.43|P-value:2.38E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.24|P-value:5.23E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.45|P-value:2.18E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.19|P-value:5.64E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.15|P-value:7.00E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.91|P-value:3.67E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.33|P-value:3.45E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.50|P-value:2.51E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:6.21|P-value:1.49E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:-5.08|P-value:1.16E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.89|P-value:3.97E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.07|P-value:9.51E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.32|P-value:3.60E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-4.04|P-value:1.93E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.51|P-value:2.39E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.73|P-value:8.03E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.31|P-value:3.94E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.90|P-value:3.85E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.92|P-value:3.61E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.24|P-value:4.84E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:-3.22|P-value:5.22E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.21|P-value:5.31E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-5.14|P-value:8.16E-8 ID:SGTC_2315|Compound:7733312|FD-Score:4.30|P-value:6.46E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.67|P-value:9.86E-7 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.04|P-value:9.78E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.69|P-value:9.09E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.07|P-value:9.29E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.11|P-value:8.05E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.06|P-value:1.28E-7 ID:SGTC_2625|Compound:euphol|FD-Score:5.63|P-value:5.61E-9 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.94|P-value:2.95E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.34|P-value:3.54E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.47|P-value:2.88E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.61|P-value:1.28E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.62|P-value:1.39E-6 ID:SGTC_2965|Compound:9082772|FD-Score:5.42|P-value:1.97E-8 ID:SGTC_3068|Compound:9116768|FD-Score:4.80|P-value:5.67E-7 ID:SGTC_3076|Compound:9116187|FD-Score:-4.59|P-value:1.46E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.69|P-value:8.46E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-8.71|P-value:4.11E-19 ID:SGTC_3144|Compound:9087057|FD-Score:3.14|P-value:7.39E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.20|P-value:5.49E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.06|P-value:1.43E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.78|P-value:5.79E-5

Top fitness defect scores for YGL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_143 4032-1194 6.51 15.7 µM 1.97E-11 16 3.68E-11
2 SGTC_925 2064-1272 6.21 59.6 µM 1.49E-10 3 2.63E-10
3 SGTC_2625 euphol 5.63 100.0 µM 5.61E-9 7 8.91E-9
4 SGTC_2965 9082772 5.42 38.6 µM 1.97E-8 mitochondrial response to ROS 14 3.02E-8
5 SGTC_3300 9124615 5.06 50.5 µM 1.43E-7 5 2.07E-7
6 SGTC_3068 9116768 4.80 49.5 µM 5.67E-7 10 7.91E-7
7 SGTC_1527 coumarin 4.73 137.0 µM 8.03E-7 7 1.11E-6
8 SGTC_2959 9079155 4.62 11.0 µM 1.39E-6 15 1.89E-6
9 SGTC_1525 8-methoxypsoralen 4.51 92.5 µM 2.39E-6 DNA damage response 18 3.20E-6
10 SGTC_824 1304-0008 4.50 100.0 µM 2.51E-6 DNA damage response 26 3.36E-6
11 SGTC_2812 7970281 4.47 58.4 µM 2.88E-6 14 3.84E-6
12 SGTC_2315 7733312 4.30 200.0 µM 6.46E-6 20 8.42E-6
13 SGTC_1132 3456-3614 4.15 2.5 µM 1.27E-5 tubulin folding & SWR complex 36 1.63E-5
14 SGTC_2055 5235184 3.92 200.0 µM 3.61E-5 ERG2 32 4.48E-5
15 SGTC_743 1275-0778 3.91 158.0 µM 3.67E-5 excess fatty acid 32 4.55E-5
16 SGTC_1736 st036774 3.90 51.0 µM 3.85E-5 34 4.77E-5
17 SGTC_961 1252-1571 3.89 372.0 µM 3.97E-5 30 4.91E-5
18 SGTC_2504 purpurogallin 3.69 52.3 µM 9.09E-5 RPP1 & pyrimidine depletion 27 1.10E-4
19 SGTC_224 benfluorex 3.65 43.9 µM 1.10E-4 8 1.33E-4
20 SGTC_2030 5175110 3.64 200.0 µM 1.15E-4 Golgi 34 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.65E-11 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.115 2.78E-11 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.098 1.45E-8 YBR184W_p YBR184W_p hom Putative protein of unknown function; YBR184W is not an essential gene
0.097 1.76E-8 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.097 2.01E-8 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.090 1.84E-7 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.089 2.52E-7 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.089 2.83E-7 YLR174W IDP2 hom Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication
0.088 3.32E-7 YNL269W BSC4 hom Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
0.087 3.91E-7 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
0.085 7.73E-7 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.085 8.85E-7 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.084 1.18E-6 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.084 1.18E-6 YPR161C SGV1 het Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
0.084 1.25E-6 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function