YGL011C / SCL1

Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL011C / SCL1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:8.91|P-value:4.62E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:9.04|P-value:2.02E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.00|P-value:3.77E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:5.13|P-value:9.13E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:7.91|P-value:1.86E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:4.66|P-value:5.02E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.73|P-value:9.28E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:7.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.78|P-value:6.75E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:4.53|P-value:7.88E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:6.45|P-value:3.47E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.23|P-value:1.84E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.74|P-value:8.93E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.61|P-value:5.85E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.83|P-value:7.00E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.33|P-value:1.49E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:5.58|P-value:1.53E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-5.61|P-value:1.20E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.11|P-value:2.66E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.71|P-value:3.64E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.81|P-value:7.51E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.24|P-value:2.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.51|P-value:1.80E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.72|P-value:3.54E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.86|P-value:6.49E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.50|P-value:4.63E-34 ID:SGTC_1712|Compound:st032288|FD-Score:5.36|P-value:3.82E-6 ID:SGTC_1715|Compound:st032160|FD-Score:4.53|P-value:7.68E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.80|P-value:6.88E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.47|P-value:9.54E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.28|P-value:5.16E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-5.82|P-value:4.84E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.76|P-value:7.62E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:9.40E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-4.70|P-value:3.82E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.77|P-value:7.65E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.67|P-value:4.89E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:13.50|P-value:5.47E-30 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.37|P-value:1.32E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.75|P-value:3.65E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.00|P-value:4.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:6.60E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.77|P-value:2.97E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.83|P-value:5.98E-14 ID:SGTC_3312|Compound:9133330|FD-Score:4.07|P-value:3.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.72|P-value:4.06E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:8.91|P-value:4.62E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:9.04|P-value:2.02E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.00|P-value:3.77E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:5.13|P-value:9.13E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:7.91|P-value:1.86E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:4.66|P-value:5.02E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.73|P-value:9.28E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:7.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.78|P-value:6.75E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:4.53|P-value:7.88E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:6.45|P-value:3.47E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.23|P-value:1.84E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.74|P-value:8.93E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.61|P-value:5.85E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.83|P-value:7.00E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.33|P-value:1.49E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:5.58|P-value:1.53E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-5.61|P-value:1.20E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.11|P-value:2.66E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.71|P-value:3.64E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.81|P-value:7.51E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.24|P-value:2.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.51|P-value:1.80E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.72|P-value:3.54E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.86|P-value:6.49E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.50|P-value:4.63E-34 ID:SGTC_1712|Compound:st032288|FD-Score:5.36|P-value:3.82E-6 ID:SGTC_1715|Compound:st032160|FD-Score:4.53|P-value:7.68E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.80|P-value:6.88E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.47|P-value:9.54E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.28|P-value:5.16E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-5.82|P-value:4.84E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.76|P-value:7.62E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:9.40E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-4.70|P-value:3.82E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.77|P-value:7.65E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.67|P-value:4.89E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:13.50|P-value:5.47E-30 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.37|P-value:1.32E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.75|P-value:3.65E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.00|P-value:4.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:6.60E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.77|P-value:2.97E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.83|P-value:5.98E-14 ID:SGTC_3312|Compound:9133330|FD-Score:4.07|P-value:3.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.72|P-value:4.06E-5

Top fitness defect scores for YGL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1597 7-benzyloxygramine 14.50 47.5 µM 4.63E-34 calcium & mitochondrial duress 9 1.02E-47 0.34
2 SGTC_2250 alverine citrate 13.50 130.0 µM 5.47E-30 4 6.29E-42 1.45
3 SGTC_64 000l-0018 9.04 272.1 µM 2.02E-14 ubiquinone biosynthesis & proteasome 15 8.12E-20 0.72
4 SGTC_36 0335-0881 8.91 14.2 µM 4.62E-14 ubiquinone biosynthesis & proteasome 5 2.64E-19 0.41
5 SGTC_137 0438-0332 7.91 85.4 µM 1.86E-11 ubiquinone biosynthesis & proteasome 11 1.30E-15 0.19
6 SGTC_1880 MG-132 6.77 525.0 µM 7.65E-9 6 6.54E-12 0.07
7 SGTC_374 0880-0231 6.45 82.3 µM 3.47E-8 iron homeostasis 3 5.54E-11 1.27
8 SGTC_312 4092-0653 5.78 6.8 µM 6.75E-7 ergosterol depletion effects on membrane 14 3.68E-9 0.03
9 SGTC_837 0091-0265 5.58 12.5 µM 1.53E-6 ubiquinone biosynthesis & proteasome 3 1.17E-8 0.64
10 SGTC_1712 st032288 5.36 53.4 µM 3.82E-6 calcium & mitochondrial duress 20 4.25E-8 0.11
11 SGTC_1750 st081859 5.28 2.4 µM 5.16E-6 endomembrane recycling 18 6.48E-8 0.21
12 SGTC_122 0236-0016 5.13 402.4 µM 9.13E-6 RNA processing & uracil transport 8 1.45E-7 0.23
13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.75 3.7 µM 3.65E-5 9 1.02E-6 0.16
14 SGTC_3323 9138564 4.72 53.9 µM 4.06E-5 4 1.18E-6 0.66
15 SGTC_2249 haloperidol 4.67 116.4 µM 4.89E-5 ergosterol depletion effects on membrane 27 1.54E-6 0.09
16 SGTC_187 1488-2104 4.66 32.7 µM 5.02E-5 calcium & mitochondrial duress 5 1.60E-6 0.23
17 SGTC_647 0140-0236 4.61 81.0 µM 5.85E-5 4 1.98E-6 0.28
18 SGTC_1715 st032160 4.53 10.2 µM 7.68E-5 2 2.90E-6 0.34
19 SGTC_320 4092-0846 4.53 5.3 µM 7.88E-5 ergosterol depletion effects on membrane 16 3.00E-6 0.14
20 SGTC_1724 st037281 4.47 8.3 µM 9.54E-5 8 3.93E-6 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.482 4.99E-195 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.478 3.57E-191 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.437 4.14E-156 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.427 1.34E-148 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.409 1.91E-135 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.409 2.96E-135 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.392 1.56E-123 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.392 1.85E-123 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.389 1.01E-121 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.373 5.51E-111 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.336 2.34E-89 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.295 1.82E-68 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.212 1.63E-35 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 8.68E-35 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.205 3.64E-33 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation