YGL012W / ERG4

C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL012W / ERG4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:1.21E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:7.44|P-value:8.85E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:-6.18|P-value:1.92E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:16.60|P-value:8.92E-33 ID:SGTC_44|Compound:0929-0055|FD-Score:8.05|P-value:7.64E-9 ID:SGTC_54|Compound:0159-0055|FD-Score:11.40|P-value:2.74E-16 ID:SGTC_55|Compound:0767-0285|FD-Score:14.70|P-value:7.80E-26 ID:SGTC_62|Compound:0180-0423|FD-Score:6.32|P-value:5.14E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:5.10|P-value:2.09E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.06|P-value:2.30E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.40|P-value:4.33E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:18.80|P-value:1.91E-41 ID:SGTC_122|Compound:0236-0016|FD-Score:8.71|P-value:4.18E-10 ID:SGTC_123|Compound:0083-0120|FD-Score:5.77|P-value:2.97E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:10.80|P-value:9.11E-15 ID:SGTC_150|Compound:3970-0969|FD-Score:12.60|P-value:1.69E-19 ID:SGTC_157|Compound:1348-1695|FD-Score:4.80|P-value:4.62E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:10.30|P-value:1.60E-13 ID:SGTC_171|Compound:k064-0041|FD-Score:5.68|P-value:3.98E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.52|P-value:9.37E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.71|P-value:3.56E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:9.42|P-value:1.46E-11 ID:SGTC_250|Compound:brefeldin a|FD-Score:7.60|P-value:4.84E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.70|P-value:5.88E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.58|P-value:5.11E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:6.31|P-value:5.29E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:10.90|P-value:5.34E-15 ID:SGTC_376|Compound:3970-0862|FD-Score:6.68|P-value:1.52E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:7.31|P-value:1.47E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:9.98|P-value:8.79E-13 ID:SGTC_398|Compound:bronopol|FD-Score:6.16|P-value:8.80E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:6.18|P-value:8.30E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.19|P-value:7.90E-6 ID:SGTC_466|Compound:geldanamycin|FD-Score:8.35|P-value:2.05E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.26|P-value:3.05E-9 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.76|P-value:1.12E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:9.29|P-value:2.73E-11 ID:SGTC_524|Compound:r073-0010|FD-Score:10.20|P-value:2.37E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:6.70|P-value:1.37E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:7.35|P-value:1.28E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:5.32|P-value:1.13E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.26|P-value:1.35E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:6.00|P-value:1.47E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:7.31|P-value:1.51E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:7.33|P-value:1.39E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:12.80|P-value:6.63E-20 ID:SGTC_800|Compound:3448-7362|FD-Score:5.79|P-value:2.77E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.16|P-value:7.91E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.61|P-value:1.90E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:7.94|P-value:1.20E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:12.60|P-value:1.37E-19 ID:SGTC_847|Compound:0342-0274|FD-Score:7.34|P-value:1.34E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:5.22|P-value:1.49E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.13|P-value:2.91E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:4.78|P-value:4.82E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.17|P-value:1.69E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:6.42|P-value:3.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.26|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.22|P-value:7.06E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:8.43|P-value:1.45E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.51|P-value:9.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.63|P-value:7.14E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.16|P-value:1.76E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.81|P-value:4.49E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.27|P-value:1.30E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.51|P-value:6.61E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.89|P-value:1.49E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:13.20|P-value:3.77E-21 ID:SGTC_1464|Compound:k208-0027|FD-Score:6.73|P-value:1.24E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.46|P-value:7.55E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:17.40|P-value:1.39E-35 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.63|P-value:7.18E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:13.20|P-value:3.55E-21 ID:SGTC_1623|Compound:st003709|FD-Score:5.48|P-value:7.19E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.77|P-value:4.99E-4 ID:SGTC_1666|Compound:st014829|FD-Score:8.17|P-value:4.50E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.63|P-value:1.76E-6 ID:SGTC_1687|Compound:st020778|FD-Score:15.10|P-value:2.96E-27 ID:SGTC_1711|Compound:st032263|FD-Score:6.99|P-value:4.86E-7 ID:SGTC_1712|Compound:st032288|FD-Score:7.25|P-value:1.90E-7 ID:SGTC_1715|Compound:st032160|FD-Score:-5.74|P-value:8.55E-6 ID:SGTC_1728|Compound:st035614|FD-Score:7.40|P-value:1.04E-7 ID:SGTC_1745|Compound:st081495|FD-Score:5.89|P-value:2.05E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.24|P-value:1.42E-4 ID:SGTC_1812|Compound:st052057|FD-Score:10.10|P-value:5.71E-13 ID:SGTC_1826|Compound:st055655|FD-Score:8.95|P-value:1.36E-10 ID:SGTC_1850|Compound:st056238|FD-Score:6.78|P-value:1.05E-6 ID:SGTC_1856|Compound:st057054|FD-Score:6.70|P-value:1.40E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.99|P-value:4.84E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:7.31|P-value:1.48E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.17|P-value:1.72E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.63|P-value:7.11E-4 ID:SGTC_2007|Compound:4011539|FD-Score:9.84|P-value:1.78E-12 ID:SGTC_2009|Compound:4012297|FD-Score:7.41|P-value:9.93E-8 ID:SGTC_2011|Compound:4012611|FD-Score:4.70|P-value:5.93E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.60|P-value:5.00E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.08|P-value:6.61E-5 ID:SGTC_2077|Compound:5212015|FD-Score:10.10|P-value:3.58E-13 ID:SGTC_2090|Compound:5301565|FD-Score:8.28|P-value:2.87E-9 ID:SGTC_2110|Compound:5483698|FD-Score:4.88|P-value:3.71E-4 ID:SGTC_2141|Compound:5621638|FD-Score:9.55|P-value:7.80E-12 ID:SGTC_2177|Compound:5811945|FD-Score:5.84|P-value:2.44E-5 ID:SGTC_2183|Compound:6420625|FD-Score:13.70|P-value:7.60E-23 ID:SGTC_2200|Compound:6600604|FD-Score:15.30|P-value:7.74E-28 ID:SGTC_2246|Compound:7293507|FD-Score:9.42|P-value:1.47E-11 ID:SGTC_2251|Compound:lansoprazole|FD-Score:5.06|P-value:2.33E-4 ID:SGTC_2322|Compound:7413319|FD-Score:17.80|P-value:2.37E-37 ID:SGTC_2323|Compound:6148992|FD-Score:5.30|P-value:1.19E-4 ID:SGTC_2363|Compound:9053361|FD-Score:10.90|P-value:7.74E-15 ID:SGTC_2399|Compound:5884133|FD-Score:6.17|P-value:8.37E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:13.60|P-value:2.40E-22 ID:SGTC_2526|Compound:patulin|FD-Score:23.70|P-value:6.13E-65 ID:SGTC_2557|Compound:derrustone|FD-Score:5.25|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.67|P-value:3.57E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:5.41|P-value:8.65E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.05|P-value:2.35E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.40|P-value:3.95E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.68|P-value:3.93E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.19|P-value:7.83E-6 ID:SGTC_2699|Compound:st077704|FD-Score:12.00|P-value:1.04E-17 ID:SGTC_2743|Compound:auranofin|FD-Score:8.27|P-value:3.00E-9 ID:SGTC_2862|Compound:9027634|FD-Score:6.66|P-value:1.60E-6 ID:SGTC_2951|Compound:9072950|FD-Score:6.99|P-value:4.92E-7 ID:SGTC_2970|Compound:9090938|FD-Score:7.57|P-value:5.35E-8 ID:SGTC_3003|Compound:9075612|FD-Score:6.55|P-value:2.38E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.64|P-value:4.40E-5 ID:SGTC_3288|Compound:9119690|FD-Score:8.44|P-value:1.40E-9 ID:SGTC_3304|Compound:9125678|FD-Score:4.51|P-value:9.67E-4 ID:SGTC_3325|Compound:9138760|FD-Score:10.50|P-value:4.16E-14 ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:1.21E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:7.44|P-value:8.85E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:-6.18|P-value:1.92E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:16.60|P-value:8.92E-33 ID:SGTC_44|Compound:0929-0055|FD-Score:8.05|P-value:7.64E-9 ID:SGTC_54|Compound:0159-0055|FD-Score:11.40|P-value:2.74E-16 ID:SGTC_55|Compound:0767-0285|FD-Score:14.70|P-value:7.80E-26 ID:SGTC_62|Compound:0180-0423|FD-Score:6.32|P-value:5.14E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:5.10|P-value:2.09E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.06|P-value:2.30E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.40|P-value:4.33E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:18.80|P-value:1.91E-41 ID:SGTC_122|Compound:0236-0016|FD-Score:8.71|P-value:4.18E-10 ID:SGTC_123|Compound:0083-0120|FD-Score:5.77|P-value:2.97E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:10.80|P-value:9.11E-15 ID:SGTC_150|Compound:3970-0969|FD-Score:12.60|P-value:1.69E-19 ID:SGTC_157|Compound:1348-1695|FD-Score:4.80|P-value:4.62E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:10.30|P-value:1.60E-13 ID:SGTC_171|Compound:k064-0041|FD-Score:5.68|P-value:3.98E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.52|P-value:9.37E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.71|P-value:3.56E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:9.42|P-value:1.46E-11 ID:SGTC_250|Compound:brefeldin a|FD-Score:7.60|P-value:4.84E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.70|P-value:5.88E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.58|P-value:5.11E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:6.31|P-value:5.29E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:10.90|P-value:5.34E-15 ID:SGTC_376|Compound:3970-0862|FD-Score:6.68|P-value:1.52E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:7.31|P-value:1.47E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:9.98|P-value:8.79E-13 ID:SGTC_398|Compound:bronopol|FD-Score:6.16|P-value:8.80E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:6.18|P-value:8.30E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.19|P-value:7.90E-6 ID:SGTC_466|Compound:geldanamycin|FD-Score:8.35|P-value:2.05E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.26|P-value:3.05E-9 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.76|P-value:1.12E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:9.29|P-value:2.73E-11 ID:SGTC_524|Compound:r073-0010|FD-Score:10.20|P-value:2.37E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:6.70|P-value:1.37E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:7.35|P-value:1.28E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:5.32|P-value:1.13E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.26|P-value:1.35E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:6.00|P-value:1.47E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:7.31|P-value:1.51E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:7.33|P-value:1.39E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:12.80|P-value:6.63E-20 ID:SGTC_800|Compound:3448-7362|FD-Score:5.79|P-value:2.77E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.16|P-value:7.91E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.61|P-value:1.90E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:7.94|P-value:1.20E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:12.60|P-value:1.37E-19 ID:SGTC_847|Compound:0342-0274|FD-Score:7.34|P-value:1.34E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:5.22|P-value:1.49E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.13|P-value:2.91E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:4.78|P-value:4.82E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.17|P-value:1.69E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:6.42|P-value:3.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.26|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.22|P-value:7.06E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:8.43|P-value:1.45E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.51|P-value:9.66E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.63|P-value:7.14E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.16|P-value:1.76E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.81|P-value:4.49E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.27|P-value:1.30E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.51|P-value:6.61E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.89|P-value:1.49E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:13.20|P-value:3.77E-21 ID:SGTC_1464|Compound:k208-0027|FD-Score:6.73|P-value:1.24E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.46|P-value:7.55E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:17.40|P-value:1.39E-35 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.63|P-value:7.18E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:13.20|P-value:3.55E-21 ID:SGTC_1623|Compound:st003709|FD-Score:5.48|P-value:7.19E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.77|P-value:4.99E-4 ID:SGTC_1666|Compound:st014829|FD-Score:8.17|P-value:4.50E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.63|P-value:1.76E-6 ID:SGTC_1687|Compound:st020778|FD-Score:15.10|P-value:2.96E-27 ID:SGTC_1711|Compound:st032263|FD-Score:6.99|P-value:4.86E-7 ID:SGTC_1712|Compound:st032288|FD-Score:7.25|P-value:1.90E-7 ID:SGTC_1715|Compound:st032160|FD-Score:-5.74|P-value:8.55E-6 ID:SGTC_1728|Compound:st035614|FD-Score:7.40|P-value:1.04E-7 ID:SGTC_1745|Compound:st081495|FD-Score:5.89|P-value:2.05E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.24|P-value:1.42E-4 ID:SGTC_1812|Compound:st052057|FD-Score:10.10|P-value:5.71E-13 ID:SGTC_1826|Compound:st055655|FD-Score:8.95|P-value:1.36E-10 ID:SGTC_1850|Compound:st056238|FD-Score:6.78|P-value:1.05E-6 ID:SGTC_1856|Compound:st057054|FD-Score:6.70|P-value:1.40E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.99|P-value:4.84E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:7.31|P-value:1.48E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.17|P-value:1.72E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.63|P-value:7.11E-4 ID:SGTC_2007|Compound:4011539|FD-Score:9.84|P-value:1.78E-12 ID:SGTC_2009|Compound:4012297|FD-Score:7.41|P-value:9.93E-8 ID:SGTC_2011|Compound:4012611|FD-Score:4.70|P-value:5.93E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.60|P-value:5.00E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.08|P-value:6.61E-5 ID:SGTC_2077|Compound:5212015|FD-Score:10.10|P-value:3.58E-13 ID:SGTC_2090|Compound:5301565|FD-Score:8.28|P-value:2.87E-9 ID:SGTC_2110|Compound:5483698|FD-Score:4.88|P-value:3.71E-4 ID:SGTC_2141|Compound:5621638|FD-Score:9.55|P-value:7.80E-12 ID:SGTC_2177|Compound:5811945|FD-Score:5.84|P-value:2.44E-5 ID:SGTC_2183|Compound:6420625|FD-Score:13.70|P-value:7.60E-23 ID:SGTC_2200|Compound:6600604|FD-Score:15.30|P-value:7.74E-28 ID:SGTC_2246|Compound:7293507|FD-Score:9.42|P-value:1.47E-11 ID:SGTC_2251|Compound:lansoprazole|FD-Score:5.06|P-value:2.33E-4 ID:SGTC_2322|Compound:7413319|FD-Score:17.80|P-value:2.37E-37 ID:SGTC_2323|Compound:6148992|FD-Score:5.30|P-value:1.19E-4 ID:SGTC_2363|Compound:9053361|FD-Score:10.90|P-value:7.74E-15 ID:SGTC_2399|Compound:5884133|FD-Score:6.17|P-value:8.37E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:13.60|P-value:2.40E-22 ID:SGTC_2526|Compound:patulin|FD-Score:23.70|P-value:6.13E-65 ID:SGTC_2557|Compound:derrustone|FD-Score:5.25|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.67|P-value:3.57E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:5.41|P-value:8.65E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.05|P-value:2.35E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.40|P-value:3.95E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.68|P-value:3.93E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.19|P-value:7.83E-6 ID:SGTC_2699|Compound:st077704|FD-Score:12.00|P-value:1.04E-17 ID:SGTC_2743|Compound:auranofin|FD-Score:8.27|P-value:3.00E-9 ID:SGTC_2862|Compound:9027634|FD-Score:6.66|P-value:1.60E-6 ID:SGTC_2951|Compound:9072950|FD-Score:6.99|P-value:4.92E-7 ID:SGTC_2970|Compound:9090938|FD-Score:7.57|P-value:5.35E-8 ID:SGTC_3003|Compound:9075612|FD-Score:6.55|P-value:2.38E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.64|P-value:4.40E-5 ID:SGTC_3288|Compound:9119690|FD-Score:8.44|P-value:1.40E-9 ID:SGTC_3304|Compound:9125678|FD-Score:4.51|P-value:9.67E-4 ID:SGTC_3325|Compound:9138760|FD-Score:10.50|P-value:4.16E-14

Top fitness defect scores for YGL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2526 patulin 23.70 37.6 µM 6.13E-65 1 1.17E-124
2 SGTC_120 rhodamine 6G 18.80 52.3 µM 1.91E-41 mitochondrial processes 1 2.95E-79
3 SGTC_2322 7413319 17.80 38.2 µM 2.37E-37 ERAD & cell cycle 3 2.42E-71
4 SGTC_1495 4469-0029 17.40 237.0 µM 1.39E-35 2 6.37E-68
5 SGTC_43 0570-0105 16.60 72.5 µM 8.92E-33 ERG2 1 1.73E-62
6 SGTC_2200 6600604 15.30 21.9 µM 7.74E-28 tubulin folding & SWR complex 5 6.29E-53
7 SGTC_1687 st020778 15.10 55.4 µM 2.96E-27 18 8.46E-52
8 SGTC_55 0767-0285 14.70 6.6 µM 7.80E-26 2 4.77E-49
9 SGTC_2183 6420625 13.70 130.5 µM 7.60E-23 mitochondrial processes 1 2.93E-43
10 SGTC_2405 ticlatone 13.60 3.5 µM 2.40E-22 6 2.72E-42
11 SGTC_1581 himbacine 13.20 57.9 µM 3.55E-21 Golgi 2 5.05E-40
12 SGTC_1377 2944-0135 13.20 198.0 µM 3.77E-21 calcium & mitochondrial duress 2 5.66E-40
13 SGTC_797 k781-0471 12.80 270.0 µM 6.63E-20 RPP1 & pyrimidine depletion 1 1.47E-37
14 SGTC_841 0251-0215 12.60 91.2 µM 1.37E-19 7 6.03E-37
15 SGTC_150 3970-0969 12.60 77.2 µM 1.69E-19 1 8.98E-37
16 SGTC_2699 st077704 12.00 54.6 µM 1.04E-17 endomembrane recycling 4 2.64E-33
17 SGTC_54 0159-0055 11.40 9.0 µM 2.74E-16 ERG2 9 1.50E-30
18 SGTC_351 caspofungin 10.90 25.0 nM 5.34E-15 cell wall 5 4.79E-28
19 SGTC_2363 9053361 10.90 176.0 µM 7.74E-15 Golgi 2 9.84E-28
20 SGTC_146 3448-8650 10.80 53.1 µM 9.11E-15 NEO1-PIK1 14 1.35E-27

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.335 2.61E-88 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.329 7.18E-85 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.284 2.69E-63 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.257 1.55E-51 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.256 3.15E-51 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.253 4.81E-50 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.244 7.85E-47 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.237 5.80E-44 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.235 2.49E-43 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.235 3.11E-43 YKL212W SAC1 hom Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
0.230 1.43E-41 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.221 2.43E-38 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.220 7.24E-38 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.205 3.30E-33 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.200 1.32E-31 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress