YGL013C / PDR1

Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL013C / PDR1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:10.70|P-value:1.10E-13 ID:SGTC_34|Compound:0469-0683|FD-Score:5.45|P-value:1.14E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:10.10|P-value:2.03E-12 ID:SGTC_61|Compound:0978-8327|FD-Score:6.85|P-value:1.51E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:18.80|P-value:3.72E-39 ID:SGTC_86|Compound:0417-1630|FD-Score:4.72|P-value:7.44E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:6.22|P-value:1.18E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:13.10|P-value:7.07E-20 ID:SGTC_156|Compound:3474-0145|FD-Score:15.00|P-value:1.26E-25 ID:SGTC_188|Compound:3229-0966|FD-Score:8.11|P-value:1.45E-8 ID:SGTC_196|Compound:k015-0023|FD-Score:10.80|P-value:7.08E-14 ID:SGTC_197|Compound:4544-0043|FD-Score:8.68|P-value:1.37E-9 ID:SGTC_202|Compound:3594-0513|FD-Score:9.47|P-value:4.08E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:6.54|P-value:4.25E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:4.82|P-value:5.79E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.63|P-value:1.73E-9 ID:SGTC_234|Compound:nsc-17383|FD-Score:6.34|P-value:8.19E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:15.40|P-value:1.15E-26 ID:SGTC_266|Compound:formosanin C|FD-Score:5.84|P-value:3.79E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:31.00|P-value:3.93E-103 ID:SGTC_291|Compound:4130-1278|FD-Score:4.74|P-value:7.14E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:17.40|P-value:6.61E-34 ID:SGTC_315|Compound:k915-0449|FD-Score:12.70|P-value:1.00E-18 ID:SGTC_349|Compound:k015-0014|FD-Score:7.76|P-value:5.70E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:4.99|P-value:3.85E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:6.59|P-value:3.70E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:7.74|P-value:6.09E-8 ID:SGTC_389|Compound:tpck|FD-Score:17.80|P-value:2.26E-35 ID:SGTC_425|Compound:3825-7017|FD-Score:14.90|P-value:3.98E-25 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.09|P-value:2.97E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:13.00|P-value:1.39E-19 ID:SGTC_462|Compound:ag-879|FD-Score:12.90|P-value:3.02E-19 ID:SGTC_470|Compound:aa-861|FD-Score:11.40|P-value:2.19E-15 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.14|P-value:2.61E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:5.02|P-value:3.51E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.22|P-value:9.23E-9 ID:SGTC_489|Compound:paxilline|FD-Score:12.40|P-value:8.21E-18 ID:SGTC_505|Compound:gw-5074|FD-Score:17.80|P-value:2.45E-35 ID:SGTC_513|Compound:4245-1575|FD-Score:6.60|P-value:3.54E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:5.20|P-value:2.24E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:9.28|P-value:9.61E-11 ID:SGTC_527|Compound:4476-4215|FD-Score:30.60|P-value:5.58E-101 ID:SGTC_528|Compound:3492-0019|FD-Score:15.60|P-value:1.77E-27 ID:SGTC_533|Compound:1222-0222|FD-Score:8.96|P-value:4.03E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:9.05|P-value:2.77E-10 ID:SGTC_585|Compound:0kpi-0023|FD-Score:11.30|P-value:3.00E-15 ID:SGTC_598|Compound:3937-0236|FD-Score:13.50|P-value:5.32E-21 ID:SGTC_628|Compound:1636-0253|FD-Score:11.00|P-value:1.88E-14 ID:SGTC_664|Compound:1222-0054|FD-Score:22.80|P-value:1.49E-56 ID:SGTC_666|Compound:0272-0154|FD-Score:7.42|P-value:2.06E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:17.30|P-value:2.68E-33 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.68|P-value:5.95E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:13.20|P-value:3.24E-20 ID:SGTC_687|Compound:k029-0044|FD-Score:11.50|P-value:1.29E-15 ID:SGTC_722|Compound:3534-0461|FD-Score:4.82|P-value:5.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.36|P-value:1.45E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.97|P-value:3.99E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:9.38|P-value:6.16E-11 ID:SGTC_841|Compound:0251-0215|FD-Score:21.50|P-value:9.19E-51 ID:SGTC_852|Compound:0418-0143|FD-Score:6.53|P-value:4.42E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:7.64|P-value:9.01E-8 ID:SGTC_860|Compound:0443-0016|FD-Score:5.18|P-value:2.32E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:10.80|P-value:5.49E-14 ID:SGTC_908|Compound:3448-7491|FD-Score:10.50|P-value:3.18E-13 ID:SGTC_928|Compound:2764-0428|FD-Score:9.79|P-value:9.10E-12 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.49|P-value:5.42E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:10.40|P-value:3.37E-13 ID:SGTC_955|Compound:1216-0110|FD-Score:8.98|P-value:3.78E-10 ID:SGTC_985|Compound:1493-0307|FD-Score:4.89|P-value:4.97E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.85|P-value:3.60E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:8.51|P-value:2.78E-9 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.45|P-value:1.13E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.73|P-value:5.22E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.37|P-value:1.40E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:7.74|P-value:6.24E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.20|P-value:4.59E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:13.60|P-value:3.10E-21 ID:SGTC_1139|Compound:k015-0024|FD-Score:14.70|P-value:2.00E-24 ID:SGTC_1173|Compound:0443-0020|FD-Score:12.80|P-value:5.45E-19 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.72|P-value:7.38E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:32.30|P-value:5.84E-112 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.71|P-value:5.52E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:17.10|P-value:1.14E-32 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.72|P-value:5.25E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.35|P-value:7.95E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:10.10|P-value:2.39E-12 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.33|P-value:1.58E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:7.38|P-value:2.38E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.80|P-value:6.21E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:10.60|P-value:1.81E-13 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.05|P-value:3.28E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.76|P-value:4.70E-5 ID:SGTC_1522|Compound:st012842|FD-Score:5.14|P-value:2.63E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:6.98|P-value:9.70E-7 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:7.21|P-value:4.41E-7 ID:SGTC_1603|Compound:st002045|FD-Score:12.10|P-value:3.44E-17 ID:SGTC_1605|Compound:st000082|FD-Score:6.24|P-value:1.12E-5 ID:SGTC_1608|Compound:st001473|FD-Score:5.79|P-value:4.27E-5 ID:SGTC_1643|Compound:st009866|FD-Score:5.05|P-value:3.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.50|P-value:2.01E-13 ID:SGTC_1687|Compound:st020778|FD-Score:19.30|P-value:3.55E-41 ID:SGTC_1694|Compound:st024011|FD-Score:15.40|P-value:6.42E-27 ID:SGTC_1700|Compound:st030840|FD-Score:30.90|P-value:6.27E-103 ID:SGTC_1706|Compound:st031321|FD-Score:4.72|P-value:7.40E-4 ID:SGTC_1707|Compound:st032323|FD-Score:9.65|P-value:1.74E-11 ID:SGTC_1712|Compound:st032288|FD-Score:8.13|P-value:1.32E-8 ID:SGTC_1733|Compound:st037357|FD-Score:5.12|P-value:2.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.21|P-value:4.40E-7 ID:SGTC_1760|Compound:st045453|FD-Score:14.20|P-value:4.76E-23 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.75|P-value:6.92E-4 ID:SGTC_1800|Compound:st050079|FD-Score:9.99|P-value:3.38E-12 ID:SGTC_1801|Compound:st050089|FD-Score:9.45|P-value:4.35E-11 ID:SGTC_1803|Compound:st050068|FD-Score:19.80|P-value:4.26E-43 ID:SGTC_1809|Compound:st050081|FD-Score:7.41|P-value:2.11E-7 ID:SGTC_1810|Compound:st050138|FD-Score:8.76|P-value:9.79E-10 ID:SGTC_1826|Compound:st055655|FD-Score:24.30|P-value:2.46E-64 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.30|P-value:1.68E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:12.60|P-value:1.61E-18 ID:SGTC_1877|Compound:wortmannin|FD-Score:14.80|P-value:7.41E-25 ID:SGTC_1916|Compound:st067606|FD-Score:10.30|P-value:5.91E-13 ID:SGTC_1930|Compound:st074634|FD-Score:5.10|P-value:2.89E-4 ID:SGTC_1934|Compound:st074720|FD-Score:17.10|P-value:1.02E-32 ID:SGTC_1941|Compound:st076221|FD-Score:12.20|P-value:1.81E-17 ID:SGTC_1970|Compound:st070122|FD-Score:4.92|P-value:4.53E-4 ID:SGTC_2036|Compound:5160441|FD-Score:6.38|P-value:7.12E-6 ID:SGTC_2157|Compound:5649910|FD-Score:5.32|P-value:1.60E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.89|P-value:4.90E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.80|P-value:1.81E-6 ID:SGTC_2312|Compound:7706453|FD-Score:5.57|P-value:8.16E-5 ID:SGTC_2322|Compound:7413319|FD-Score:13.20|P-value:3.17E-20 ID:SGTC_2336|Compound:9001819|FD-Score:-4.91|P-value:1.84E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-4.91|P-value:1.84E-4 ID:SGTC_2363|Compound:9053361|FD-Score:10.40|P-value:4.42E-13 ID:SGTC_2365|Compound:9042475|FD-Score:5.08|P-value:3.07E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-7.80|P-value:1.20E-8 ID:SGTC_2411|Compound:st077133|FD-Score:12.40|P-value:7.88E-18 ID:SGTC_2416|Compound:tofa|FD-Score:25.30|P-value:3.37E-69 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.74|P-value:1.07E-9 ID:SGTC_2424|Compound:5537928|FD-Score:5.80|P-value:4.16E-5 ID:SGTC_2435|Compound:5706476|FD-Score:7.02|P-value:8.49E-7 ID:SGTC_2475|Compound:5812728|FD-Score:6.86|P-value:1.50E-6 ID:SGTC_2481|Compound:5478948|FD-Score:5.22|P-value:2.11E-4 ID:SGTC_2482|Compound:5981709|FD-Score:15.90|P-value:1.55E-28 ID:SGTC_2508|Compound:celastrol|FD-Score:16.90|P-value:6.45E-32 ID:SGTC_2517|Compound:totarol|FD-Score:6.85|P-value:1.52E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:7.16|P-value:5.28E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:6.77|P-value:2.03E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:6.15|P-value:1.47E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:6.50|P-value:4.89E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.50|P-value:1.51E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.99|P-value:3.45E-12 ID:SGTC_2645|Compound:abamectin|FD-Score:4.70|P-value:7.84E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.92|P-value:4.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.50|P-value:1.08E-15 ID:SGTC_2659|Compound:sanguinarine|FD-Score:14.60|P-value:3.30E-24 ID:SGTC_2696|Compound:st077691|FD-Score:5.51|P-value:9.65E-5 ID:SGTC_2701|Compound:st077767|FD-Score:8.01|P-value:2.17E-8 ID:SGTC_2735|Compound:sertaconazole|FD-Score:5.49|P-value:1.01E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:22.80|P-value:8.46E-57 ID:SGTC_2755|Compound:lomerizine|FD-Score:6.24|P-value:1.13E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.76|P-value:4.68E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.37|P-value:1.40E-4 ID:SGTC_2858|Compound:9025781|FD-Score:11.00|P-value:2.38E-14 ID:SGTC_2862|Compound:9027634|FD-Score:10.70|P-value:8.57E-14 ID:SGTC_2891|Compound:9063876|FD-Score:-4.48|P-value:5.61E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.07|P-value:3.10E-4 ID:SGTC_3025|Compound:9087895|FD-Score:14.90|P-value:3.05E-25 ID:SGTC_3030|Compound:9087619|FD-Score:-4.36|P-value:7.44E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.33|P-value:7.98E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.50|P-value:6.20E-24 ID:SGTC_3060|Compound:1327-0027|FD-Score:12.80|P-value:4.44E-19 ID:SGTC_3063|Compound:1327-0034|FD-Score:13.70|P-value:1.71E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:11.20|P-value:6.19E-15 ID:SGTC_3098|Compound:9119039|FD-Score:8.36|P-value:5.17E-9 ID:SGTC_3120|Compound:9124077|FD-Score:11.00|P-value:2.23E-14 ID:SGTC_3223|Compound:9129970|FD-Score:4.82|P-value:5.80E-4 ID:SGTC_3241|Compound:9133421|FD-Score:6.51|P-value:4.70E-6 ID:SGTC_3285|Compound:9112818|FD-Score:6.19|P-value:1.29E-5 ID:SGTC_3288|Compound:9119690|FD-Score:7.30|P-value:3.14E-7 ID:SGTC_3304|Compound:9125678|FD-Score:14.40|P-value:1.74E-23 ID:SGTC_3311|Compound:9131146|FD-Score:12.10|P-value:3.93E-17 ID:SGTC_3322|Compound:9139058|FD-Score:5.99|P-value:2.42E-5 ID:SGTC_3350|Compound:9150499|FD-Score:13.10|P-value:9.90E-20 ID:SGTC_3351|Compound:9150312|FD-Score:6.77|P-value:2.04E-6 ID:SGTC_3356|Compound:9151811|FD-Score:9.88|P-value:5.80E-12 ID:SGTC_15|Compound:0266-0086|FD-Score:10.70|P-value:1.10E-13 ID:SGTC_34|Compound:0469-0683|FD-Score:5.45|P-value:1.14E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:10.10|P-value:2.03E-12 ID:SGTC_61|Compound:0978-8327|FD-Score:6.85|P-value:1.51E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:18.80|P-value:3.72E-39 ID:SGTC_86|Compound:0417-1630|FD-Score:4.72|P-value:7.44E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:6.22|P-value:1.18E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:13.10|P-value:7.07E-20 ID:SGTC_156|Compound:3474-0145|FD-Score:15.00|P-value:1.26E-25 ID:SGTC_188|Compound:3229-0966|FD-Score:8.11|P-value:1.45E-8 ID:SGTC_196|Compound:k015-0023|FD-Score:10.80|P-value:7.08E-14 ID:SGTC_197|Compound:4544-0043|FD-Score:8.68|P-value:1.37E-9 ID:SGTC_202|Compound:3594-0513|FD-Score:9.47|P-value:4.08E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:6.54|P-value:4.25E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:4.82|P-value:5.79E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.63|P-value:1.73E-9 ID:SGTC_234|Compound:nsc-17383|FD-Score:6.34|P-value:8.19E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:15.40|P-value:1.15E-26 ID:SGTC_266|Compound:formosanin C|FD-Score:5.84|P-value:3.79E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:31.00|P-value:3.93E-103 ID:SGTC_291|Compound:4130-1278|FD-Score:4.74|P-value:7.14E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:17.40|P-value:6.61E-34 ID:SGTC_315|Compound:k915-0449|FD-Score:12.70|P-value:1.00E-18 ID:SGTC_349|Compound:k015-0014|FD-Score:7.76|P-value:5.70E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:4.99|P-value:3.85E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:6.59|P-value:3.70E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:7.74|P-value:6.09E-8 ID:SGTC_389|Compound:tpck|FD-Score:17.80|P-value:2.26E-35 ID:SGTC_425|Compound:3825-7017|FD-Score:14.90|P-value:3.98E-25 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.09|P-value:2.97E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:13.00|P-value:1.39E-19 ID:SGTC_462|Compound:ag-879|FD-Score:12.90|P-value:3.02E-19 ID:SGTC_470|Compound:aa-861|FD-Score:11.40|P-value:2.19E-15 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.14|P-value:2.61E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:5.02|P-value:3.51E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.22|P-value:9.23E-9 ID:SGTC_489|Compound:paxilline|FD-Score:12.40|P-value:8.21E-18 ID:SGTC_505|Compound:gw-5074|FD-Score:17.80|P-value:2.45E-35 ID:SGTC_513|Compound:4245-1575|FD-Score:6.60|P-value:3.54E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:5.20|P-value:2.24E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:9.28|P-value:9.61E-11 ID:SGTC_527|Compound:4476-4215|FD-Score:30.60|P-value:5.58E-101 ID:SGTC_528|Compound:3492-0019|FD-Score:15.60|P-value:1.77E-27 ID:SGTC_533|Compound:1222-0222|FD-Score:8.96|P-value:4.03E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:9.05|P-value:2.77E-10 ID:SGTC_585|Compound:0kpi-0023|FD-Score:11.30|P-value:3.00E-15 ID:SGTC_598|Compound:3937-0236|FD-Score:13.50|P-value:5.32E-21 ID:SGTC_628|Compound:1636-0253|FD-Score:11.00|P-value:1.88E-14 ID:SGTC_664|Compound:1222-0054|FD-Score:22.80|P-value:1.49E-56 ID:SGTC_666|Compound:0272-0154|FD-Score:7.42|P-value:2.06E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:17.30|P-value:2.68E-33 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.68|P-value:5.95E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:13.20|P-value:3.24E-20 ID:SGTC_687|Compound:k029-0044|FD-Score:11.50|P-value:1.29E-15 ID:SGTC_722|Compound:3534-0461|FD-Score:4.82|P-value:5.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.36|P-value:1.45E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.97|P-value:3.99E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:9.38|P-value:6.16E-11 ID:SGTC_841|Compound:0251-0215|FD-Score:21.50|P-value:9.19E-51 ID:SGTC_852|Compound:0418-0143|FD-Score:6.53|P-value:4.42E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:7.64|P-value:9.01E-8 ID:SGTC_860|Compound:0443-0016|FD-Score:5.18|P-value:2.32E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:10.80|P-value:5.49E-14 ID:SGTC_908|Compound:3448-7491|FD-Score:10.50|P-value:3.18E-13 ID:SGTC_928|Compound:2764-0428|FD-Score:9.79|P-value:9.10E-12 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.49|P-value:5.42E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:10.40|P-value:3.37E-13 ID:SGTC_955|Compound:1216-0110|FD-Score:8.98|P-value:3.78E-10 ID:SGTC_985|Compound:1493-0307|FD-Score:4.89|P-value:4.97E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.85|P-value:3.60E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:8.51|P-value:2.78E-9 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.45|P-value:1.13E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.73|P-value:5.22E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.37|P-value:1.40E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:7.74|P-value:6.24E-8 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.20|P-value:4.59E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:13.60|P-value:3.10E-21 ID:SGTC_1139|Compound:k015-0024|FD-Score:14.70|P-value:2.00E-24 ID:SGTC_1173|Compound:0443-0020|FD-Score:12.80|P-value:5.45E-19 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.72|P-value:7.38E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:32.30|P-value:5.84E-112 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.71|P-value:5.52E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:17.10|P-value:1.14E-32 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.72|P-value:5.25E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:6.35|P-value:7.95E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:10.10|P-value:2.39E-12 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.33|P-value:1.58E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:7.38|P-value:2.38E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.80|P-value:6.21E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:10.60|P-value:1.81E-13 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.05|P-value:3.28E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.76|P-value:4.70E-5 ID:SGTC_1522|Compound:st012842|FD-Score:5.14|P-value:2.63E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:6.98|P-value:9.70E-7 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:7.21|P-value:4.41E-7 ID:SGTC_1603|Compound:st002045|FD-Score:12.10|P-value:3.44E-17 ID:SGTC_1605|Compound:st000082|FD-Score:6.24|P-value:1.12E-5 ID:SGTC_1608|Compound:st001473|FD-Score:5.79|P-value:4.27E-5 ID:SGTC_1643|Compound:st009866|FD-Score:5.05|P-value:3.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.50|P-value:2.01E-13 ID:SGTC_1687|Compound:st020778|FD-Score:19.30|P-value:3.55E-41 ID:SGTC_1694|Compound:st024011|FD-Score:15.40|P-value:6.42E-27 ID:SGTC_1700|Compound:st030840|FD-Score:30.90|P-value:6.27E-103 ID:SGTC_1706|Compound:st031321|FD-Score:4.72|P-value:7.40E-4 ID:SGTC_1707|Compound:st032323|FD-Score:9.65|P-value:1.74E-11 ID:SGTC_1712|Compound:st032288|FD-Score:8.13|P-value:1.32E-8 ID:SGTC_1733|Compound:st037357|FD-Score:5.12|P-value:2.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.21|P-value:4.40E-7 ID:SGTC_1760|Compound:st045453|FD-Score:14.20|P-value:4.76E-23 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.75|P-value:6.92E-4 ID:SGTC_1800|Compound:st050079|FD-Score:9.99|P-value:3.38E-12 ID:SGTC_1801|Compound:st050089|FD-Score:9.45|P-value:4.35E-11 ID:SGTC_1803|Compound:st050068|FD-Score:19.80|P-value:4.26E-43 ID:SGTC_1809|Compound:st050081|FD-Score:7.41|P-value:2.11E-7 ID:SGTC_1810|Compound:st050138|FD-Score:8.76|P-value:9.79E-10 ID:SGTC_1826|Compound:st055655|FD-Score:24.30|P-value:2.46E-64 ID:SGTC_1874|Compound:staurosporine|FD-Score:5.30|P-value:1.68E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:12.60|P-value:1.61E-18 ID:SGTC_1877|Compound:wortmannin|FD-Score:14.80|P-value:7.41E-25 ID:SGTC_1916|Compound:st067606|FD-Score:10.30|P-value:5.91E-13 ID:SGTC_1930|Compound:st074634|FD-Score:5.10|P-value:2.89E-4 ID:SGTC_1934|Compound:st074720|FD-Score:17.10|P-value:1.02E-32 ID:SGTC_1941|Compound:st076221|FD-Score:12.20|P-value:1.81E-17 ID:SGTC_1970|Compound:st070122|FD-Score:4.92|P-value:4.53E-4 ID:SGTC_2036|Compound:5160441|FD-Score:6.38|P-value:7.12E-6 ID:SGTC_2157|Compound:5649910|FD-Score:5.32|P-value:1.60E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.89|P-value:4.90E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.80|P-value:1.81E-6 ID:SGTC_2312|Compound:7706453|FD-Score:5.57|P-value:8.16E-5 ID:SGTC_2322|Compound:7413319|FD-Score:13.20|P-value:3.17E-20 ID:SGTC_2336|Compound:9001819|FD-Score:-4.91|P-value:1.84E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-4.91|P-value:1.84E-4 ID:SGTC_2363|Compound:9053361|FD-Score:10.40|P-value:4.42E-13 ID:SGTC_2365|Compound:9042475|FD-Score:5.08|P-value:3.07E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-7.80|P-value:1.20E-8 ID:SGTC_2411|Compound:st077133|FD-Score:12.40|P-value:7.88E-18 ID:SGTC_2416|Compound:tofa|FD-Score:25.30|P-value:3.37E-69 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.74|P-value:1.07E-9 ID:SGTC_2424|Compound:5537928|FD-Score:5.80|P-value:4.16E-5 ID:SGTC_2435|Compound:5706476|FD-Score:7.02|P-value:8.49E-7 ID:SGTC_2475|Compound:5812728|FD-Score:6.86|P-value:1.50E-6 ID:SGTC_2481|Compound:5478948|FD-Score:5.22|P-value:2.11E-4 ID:SGTC_2482|Compound:5981709|FD-Score:15.90|P-value:1.55E-28 ID:SGTC_2508|Compound:celastrol|FD-Score:16.90|P-value:6.45E-32 ID:SGTC_2517|Compound:totarol|FD-Score:6.85|P-value:1.52E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:7.16|P-value:5.28E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:6.77|P-value:2.03E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:6.15|P-value:1.47E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:6.50|P-value:4.89E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.50|P-value:1.51E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.99|P-value:3.45E-12 ID:SGTC_2645|Compound:abamectin|FD-Score:4.70|P-value:7.84E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.92|P-value:4.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.50|P-value:1.08E-15 ID:SGTC_2659|Compound:sanguinarine|FD-Score:14.60|P-value:3.30E-24 ID:SGTC_2696|Compound:st077691|FD-Score:5.51|P-value:9.65E-5 ID:SGTC_2701|Compound:st077767|FD-Score:8.01|P-value:2.17E-8 ID:SGTC_2735|Compound:sertaconazole|FD-Score:5.49|P-value:1.01E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:22.80|P-value:8.46E-57 ID:SGTC_2755|Compound:lomerizine|FD-Score:6.24|P-value:1.13E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.76|P-value:4.68E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.37|P-value:1.40E-4 ID:SGTC_2858|Compound:9025781|FD-Score:11.00|P-value:2.38E-14 ID:SGTC_2862|Compound:9027634|FD-Score:10.70|P-value:8.57E-14 ID:SGTC_2891|Compound:9063876|FD-Score:-4.48|P-value:5.61E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.07|P-value:3.10E-4 ID:SGTC_3025|Compound:9087895|FD-Score:14.90|P-value:3.05E-25 ID:SGTC_3030|Compound:9087619|FD-Score:-4.36|P-value:7.44E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.33|P-value:7.98E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:14.50|P-value:6.20E-24 ID:SGTC_3060|Compound:1327-0027|FD-Score:12.80|P-value:4.44E-19 ID:SGTC_3063|Compound:1327-0034|FD-Score:13.70|P-value:1.71E-21 ID:SGTC_3064|Compound:1327-0027|FD-Score:11.20|P-value:6.19E-15 ID:SGTC_3098|Compound:9119039|FD-Score:8.36|P-value:5.17E-9 ID:SGTC_3120|Compound:9124077|FD-Score:11.00|P-value:2.23E-14 ID:SGTC_3223|Compound:9129970|FD-Score:4.82|P-value:5.80E-4 ID:SGTC_3241|Compound:9133421|FD-Score:6.51|P-value:4.70E-6 ID:SGTC_3285|Compound:9112818|FD-Score:6.19|P-value:1.29E-5 ID:SGTC_3288|Compound:9119690|FD-Score:7.30|P-value:3.14E-7 ID:SGTC_3304|Compound:9125678|FD-Score:14.40|P-value:1.74E-23 ID:SGTC_3311|Compound:9131146|FD-Score:12.10|P-value:3.93E-17 ID:SGTC_3322|Compound:9139058|FD-Score:5.99|P-value:2.42E-5 ID:SGTC_3350|Compound:9150499|FD-Score:13.10|P-value:9.90E-20 ID:SGTC_3351|Compound:9150312|FD-Score:6.77|P-value:2.04E-6 ID:SGTC_3356|Compound:9151811|FD-Score:9.88|P-value:5.80E-12

Top fitness defect scores for YGL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1243 0416-0003 32.30 5.7 µM 5.84E-112 PDR1 1 7.17E-229
2 SGTC_275 trichlorophene 31.00 5.7 µM 3.93E-103 mitochondrial stress 1 9.56E-211
3 SGTC_1700 st030840 30.90 7.9 µM 6.27E-103 PDR1 1 2.49E-210
4 SGTC_527 4476-4215 30.60 268.0 µM 5.58E-101 PDR1 1 2.50E-206
5 SGTC_2416 tofa 25.30 880.0 nM 3.37E-69 sphingolipid biosynthesis & PDR1 3 4.73E-141
6 SGTC_1826 st055655 24.30 41.6 µM 2.46E-64 ERG2 2 4.66E-131
7 SGTC_2752 diclazuril 22.80 33.1 µM 8.46E-57 2 1.44E-115
8 SGTC_664 1222-0054 22.80 14.9 µM 1.49E-56 sphingolipid biosynthesis & PDR1 2 4.58E-115
9 SGTC_841 0251-0215 21.50 91.2 µM 9.19E-51 2 3.68E-103
10 SGTC_1803 st050068 19.80 52.4 µM 4.26E-43 NEO1-PIK1 1 2.14E-87
11 SGTC_1687 st020778 19.30 55.4 µM 3.55E-41 10 1.91E-83
12 SGTC_65 0798-0905 18.80 35.0 µM 3.72E-39 calcium & mitochondrial duress 2 2.73E-79
13 SGTC_389 tpck 17.80 16.7 µM 2.26E-35 1 1.65E-71
14 SGTC_505 gw-5074 17.80 63.9 µM 2.45E-35 5 1.95E-71
15 SGTC_295 k015-0027 17.40 31.0 µM 6.61E-34 PDR1 1 1.72E-68
16 SGTC_676 falcarinol 17.30 140.0 µM 2.68E-33 1 3.08E-67
17 SGTC_1934 st074720 17.10 32.6 µM 1.02E-32 1 4.80E-66
18 SGTC_1277 0873-0036 17.10 22.0 µM 1.14E-32 PDR1 1 6.07E-66
19 SGTC_2508 celastrol 16.90 40.5 µM 6.45E-32 PDR1 1 2.13E-64
20 SGTC_2482 5981709 15.90 142.7 µM 1.55E-28 PDR1 1 1.93E-57

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.443 2.39E-161 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.345 3.55E-94 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.335 1.51E-88 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.303 4.73E-72 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.302 1.31E-71 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.286 2.68E-64 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.284 1.60E-63 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.264 1.32E-54 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.255 6.58E-51 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.253 4.00E-50 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.248 2.76E-48 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.245 4.65E-47 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.241 1.21E-45 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.239 1.05E-44 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.230 1.89E-41 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication