YGL015C_p

Putative protein of unknown function; null mutants accumulate cargo in the Golgi

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL015C / YGL015C

Click on Significant Values for Screen Details ID:SGTC_368|Compound:fentichlor|FD-Score:-4.53|P-value:5.09E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.24|P-value:2.39E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.00|P-value:6.01E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.75|P-value:1.46E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:3.45|P-value:9.62E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.81|P-value:1.91E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.61|P-value:4.75E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:2.88|P-value:9.20E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.24|P-value:2.35E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.87|P-value:9.54E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.94|P-value:1.07E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.32|P-value:1.68E-4 ID:SGTC_1677|Compound:st019204|FD-Score:5.99|P-value:4.99E-11 ID:SGTC_1755|Compound:st041960|FD-Score:-3.70|P-value:3.23E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.91|P-value:1.20E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.57|P-value:4.08E-7 ID:SGTC_2117|Compound:5521686|FD-Score:5.08|P-value:2.13E-8 ID:SGTC_2120|Compound:5538279|FD-Score:4.03|P-value:6.79E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.33|P-value:1.47E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-2.94|P-value:7.57E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.62|P-value:3.00E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:9.86|P-value:9.90E-27 ID:SGTC_2802|Compound:7925815|FD-Score:-2.94|P-value:7.51E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-2.90|P-value:8.75E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.02|P-value:5.51E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.30|P-value:1.84E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.21|P-value:2.76E-6 ID:SGTC_3353|Compound:9151644|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.53|P-value:5.09E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.24|P-value:2.39E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.00|P-value:6.01E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.75|P-value:1.46E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:3.45|P-value:9.62E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.81|P-value:1.91E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.61|P-value:4.75E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:2.88|P-value:9.20E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.24|P-value:2.35E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:2.87|P-value:9.54E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.94|P-value:1.07E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.32|P-value:1.68E-4 ID:SGTC_1677|Compound:st019204|FD-Score:5.99|P-value:4.99E-11 ID:SGTC_1755|Compound:st041960|FD-Score:-3.70|P-value:3.23E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.91|P-value:1.20E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.57|P-value:4.08E-7 ID:SGTC_2117|Compound:5521686|FD-Score:5.08|P-value:2.13E-8 ID:SGTC_2120|Compound:5538279|FD-Score:4.03|P-value:6.79E-6 ID:SGTC_2123|Compound:5259487|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.33|P-value:1.47E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-2.94|P-value:7.57E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.62|P-value:3.00E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:9.86|P-value:9.90E-27 ID:SGTC_2802|Compound:7925815|FD-Score:-2.94|P-value:7.51E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-2.90|P-value:8.75E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.02|P-value:5.51E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.30|P-value:1.84E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.21|P-value:2.76E-6 ID:SGTC_3353|Compound:9151644|FD-Score:3.21|P-value:2.68E-4

Top fitness defect scores for YGL015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 9.86 69.3 µM 9.90E-27 12 3.23E-23
2 SGTC_1677 st019204 5.99 53.9 µM 4.99E-11 2 1.04E-9
3 SGTC_2117 5521686 5.08 200.0 µM 2.13E-8 4 1.93E-7
4 SGTC_534 k292-0788 4.75 63.4 µM 1.46E-7 mitochondrial processes 13 1.02E-6
5 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.62 15.3 µM 3.00E-7 18 1.89E-6
6 SGTC_2105 5350118 4.57 200.0 µM 4.08E-7 15 2.46E-6
7 SGTC_3223 9129970 4.21 49.5 µM 2.76E-6 20 1.28E-5
8 SGTC_2120 5538279 4.03 152.0 µM 6.79E-6 18 2.80E-5
9 SGTC_1218 1348-1416 3.94 30.7 µM 1.07E-5 SWF1 & branched chain AA biosynthesis 14 4.14E-5
10 SGTC_1843 st055809 3.91 45.5 µM 1.20E-5 17 4.57E-5
11 SGTC_905 2-aminofluorene 3.81 215.0 µM 1.91E-5 cell wall signaling 32 6.83E-5
12 SGTC_1007 4101-0031 3.61 70.0 µM 4.75E-5 25 1.50E-4
13 SGTC_751 0833-0568 3.45 350.0 µM 9.62E-5 39 2.77E-4
14 SGTC_2123 5259487 3.35 200.0 µM 1.49E-4 35 4.05E-4
15 SGTC_1263 0774-1208 3.32 64.8 µM 1.68E-4 78 4.49E-4
16 SGTC_3222 9128301 3.30 49.5 µM 1.84E-4 60S ribosome export 46 4.85E-4
17 SGTC_1130 3454-2858 3.24 15.9 µM 2.35E-4 NEO1 124 6.01E-4
18 SGTC_3353 9151644 3.21 39.3 µM 2.68E-4 40 6.72E-4
19 SGTC_1025 k007-0731 3.10 70.0 µM 4.13E-4 51 9.79E-4
20 SGTC_3022 9087993 3.02 49.5 µM 5.51E-4 26 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.20E-23 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.148 6.70E-18 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.133 9.32E-15 YOR356W CIR2 hom Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response
0.133 1.05E-14 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.129 8.00E-14 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.117 1.00E-11 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.117 1.21E-11 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.110 1.54E-10 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.109 2.19E-10 YMR141C_d YMR141C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.21E-10 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.101 4.06E-9 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.101 4.64E-9 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.101 5.37E-9 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.100 7.56E-9 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.100 7.48E-9 YDR402C DIT2 hom N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s