HIPHOP chemogenomics database

YGL017W / ATE1

Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL017W / ATE1

Click on Significant Values for Screen Details

Top fitness defect scores for YGL017W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	5.34	3.7 µM	1.80E-9		22	4.68E-8
2	SGTC_2386	9075165	4.85	157.4 µM	4.24E-8		3	6.29E-7
3	SGTC_6	0844-0013	4.58	19.8 µM	2.13E-7		52	2.38E-6
4	SGTC_445	e6 berbamine	4.25	66.0 µM	1.31E-6	NEO1-PIK1	93	1.07E-5
5	SGTC_1563	conessine	4.05	56.1 µM	3.74E-6		13	2.52E-5
6	SGTC_2514	salinomycin	3.78	42.7 µM	1.49E-5		52	7.92E-5
7	SGTC_1572	epiandrosterone	3.77	68.9 µM	1.56E-5		33	8.20E-5
8	SGTC_2839	9003951	3.60	26.0 µM	3.49E-5		17	1.60E-4
9	SGTC_2876	9059903	3.44	26.0 µM	7.19E-5		25	2.91E-4
10	SGTC_2338	7999974	3.40	200.0 µM	8.72E-5		44	3.41E-4
11	SGTC_1938	st074717	3.31	56.4 µM	1.26E-4		25	4.64E-4
12	SGTC_1903	st060211	3.26	78.3 µM	1.58E-4		54	5.57E-4
13	SGTC_99	0109-0120	3.26	622.8 µM	1.61E-4		35	5.67E-4
14	SGTC_2640	pentamidine	3.20	10.4 µM	2.06E-4	mitochondrial processes	60	6.95E-4
15	SGTC_1059	3448-6867	3.18	171.0 µM	2.17E-4		33	7.27E-4
16	SGTC_1093	fluphenazine	3.11	8.0 µM	2.99E-4		45	9.48E-4
17	SGTC_2763	lisinopril	3.10	49.3 µM	3.03E-4		31	9.56E-4
18	SGTC_376	3970-0862	3.02	59.1 µM	4.17E-4		58	0.00125
19	SGTC_2693	st077581	3.00	40.7 µM	4.61E-4		91	0.00136
20	SGTC_1984	st072354	2.92	53.1 µM	6.33E-4		50	0.00176

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.278	9.00E-61	YER067C-A_d	YER067C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.269	1.46E-56	YDR068W	DOS2	hom	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.241	9.38E-46	YMR173W	DDR48	hom	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.234	4.06E-43	YKL171W	NNK1	hom	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.232	4.11E-42	YMR129W	POM152	hom	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.230	1.91E-41	YBL086C_p	YBL086C_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.222	8.60E-39	YLR288C	MEC3	hom	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.222	1.15E-38	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.213	9.37E-36	YML074C	FPR3	hom	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.211	4.72E-35	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.210	7.32E-35	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.207	6.79E-34	YDL049C	KNH1	hom	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.204	6.46E-33	YJR092W	BUD4	hom	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.204	9.79E-33	YNL242W	ATG2	hom	Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.202	2.40E-32	YKL030W_d	YKL030W_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1