YGL018C / JAC1

Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL018C / JAC1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.00|P-value:9.39E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.17|P-value:5.18E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.20|P-value:4.51E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.98|P-value:2.15E-10 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.68|P-value:5.95E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.59|P-value:8.65E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.05|P-value:7.97E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.10|P-value:5.85E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-2.97|P-value:9.34E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:5.63|P-value:2.53E-9 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.11|P-value:6.26E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.50|P-value:1.27E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.52|P-value:1.29E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.42|P-value:1.98E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.05|P-value:1.30E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.82|P-value:3.77E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.84|P-value:3.34E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.69|P-value:6.60E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.13|P-value:9.17E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.16|P-value:5.26E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.15|P-value:5.49E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.04|P-value:7.30E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.84|P-value:2.92E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.22|P-value:3.76E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-5.23|P-value:2.26E-8 ID:SGTC_2923|Compound:7992654|FD-Score:-3.34|P-value:2.39E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.03|P-value:1.26E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.53|P-value:1.11E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.25|P-value:3.38E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.00|P-value:9.39E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.17|P-value:5.18E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.20|P-value:4.51E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.98|P-value:2.15E-10 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.68|P-value:5.95E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.59|P-value:8.65E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.05|P-value:7.97E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.10|P-value:5.85E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-2.97|P-value:9.34E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.32|P-value:2.90E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:5.63|P-value:2.53E-9 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.11|P-value:6.26E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.50|P-value:1.27E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.52|P-value:1.29E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.13|P-value:5.95E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.42|P-value:1.98E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.05|P-value:1.30E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.82|P-value:3.77E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.84|P-value:3.34E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.69|P-value:6.60E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.13|P-value:9.17E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.16|P-value:5.26E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.15|P-value:5.49E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.04|P-value:7.30E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.84|P-value:2.92E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.22|P-value:3.76E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-5.23|P-value:2.26E-8 ID:SGTC_2923|Compound:7992654|FD-Score:-3.34|P-value:2.39E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.03|P-value:1.26E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.11|P-value:6.32E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.53|P-value:1.11E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.25|P-value:3.38E-4

Top fitness defect scores for YGL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1408 3909-7976 5.63 48.8 µM 2.53E-9 Golgi 1 9.10E-9 0.49
2 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.13 100.0 µM 9.17E-6 6 1.82E-5 0.08
3 SGTC_1878 temozolomide 4.05 1.0 mM 1.30E-5 2 2.52E-5 0.28
4 SGTC_2123 5259487 3.84 200.0 µM 3.34E-5 2 6.03E-5 0.26
5 SGTC_1942 st076330 3.82 65.2 µM 3.77E-5 5 6.77E-5 0.10
6 SGTC_2429 5902844 3.69 64.4 µM 6.60E-5 10 1.14E-4 0.18
7 SGTC_274 sirtinol 3.61 40.1 µM 8.94E-5 18 1.51E-4 0.01
8 SGTC_1632 st005650 3.52 90.0 µM 1.29E-4 9 2.12E-4 0.13
9 SGTC_3276 9139060 3.48 49.5 µM 1.53E-4 60S ribosome export 7 2.48E-4 0.18
10 SGTC_3156 9099931 3.44 49.5 µM 1.84E-4 5 2.95E-4 0.07
11 SGTC_1876 myriocin 3.42 605.0 nM 1.98E-4 10 3.16E-4 0.01
12 SGTC_1378 2093-0007 3.32 380.0 nM 2.90E-4 13 4.50E-4 0.09
13 SGTC_741 4582-0002 3.20 126.0 µM 4.51E-4 8 6.80E-4 0.16
14 SGTC_311 1315-0136 3.17 58.0 µM 5.18E-4 12 7.73E-4 0.08
15 SGTC_2560 caryophyllene 3.16 100.0 µM 5.26E-4 15 7.84E-4 0.03
16 SGTC_2781 5567276 3.15 71.4 µM 5.49E-4 18 8.16E-4 0.02
17 SGTC_1710 st031758 3.13 61.5 µM 5.95E-4 12 8.80E-4 0.11
18 SGTC_1418 3966-3099 3.11 2.4 µM 6.26E-4 11 9.22E-4 0.03
19 SGTC_3052 9092717 3.11 49.5 µM 6.32E-4 8 9.30E-4 0.00
20 SGTC_1092 toremifene 3.05 6.3 µM 7.97E-4 15 0.00115 0.29

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.24E-25 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.133 1.20E-14 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.130 4.05E-14 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.128 1.17E-13 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.127 2.08E-13 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.126 1.99E-13 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.126 2.35E-13 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.111 1.03E-10 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.110 1.98E-10 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.106 7.19E-10 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.106 8.64E-10 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.105 1.01E-9 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.104 1.38E-9 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.103 2.42E-9 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.103 2.51E-9 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress