YGL019W / CKB1

Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL019W / CKB1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-7.44|P-value:1.40E-10 ID:SGTC_61|Compound:0978-8327|FD-Score:4.60|P-value:4.80E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:9.24|P-value:2.48E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.10|P-value:6.20E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:7.29|P-value:3.18E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.78|P-value:2.46E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.91|P-value:1.04E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.53|P-value:5.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:8.93|P-value:1.94E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:13.10|P-value:5.78E-29 ID:SGTC_158|Compound:k038-0087|FD-Score:8.69|P-value:8.71E-14 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:4.05E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:13.00|P-value:2.31E-28 ID:SGTC_181|Compound:1447-1644|FD-Score:5.86|P-value:3.43E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:4.36|P-value:1.09E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.08|P-value:2.74E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:25.30|P-value:4.98E-102 ID:SGTC_232|Compound:clozapine|FD-Score:12.50|P-value:1.33E-26 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.66|P-value:3.96E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.96|P-value:2.17E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.61|P-value:4.75E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.17|P-value:8.33E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:15.00|P-value:3.23E-37 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.10|P-value:2.50E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.40|P-value:9.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.13|P-value:4.82E-15 ID:SGTC_312|Compound:4092-0653|FD-Score:11.70|P-value:2.30E-23 ID:SGTC_313|Compound:3474-0040|FD-Score:20.00|P-value:1.34E-64 ID:SGTC_320|Compound:4092-0846|FD-Score:9.16|P-value:4.04E-15 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.08|P-value:2.67E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:7.12|P-value:7.81E-10 ID:SGTC_347|Compound:4534-1311|FD-Score:6.49|P-value:1.87E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:9.96|P-value:1.51E-17 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.04|P-value:9.37E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:6.46|P-value:2.22E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:22.20|P-value:1.32E-79 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.11|P-value:7.28E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.69|P-value:8.94E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.50|P-value:1.49E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:6.45|P-value:2.31E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.94|P-value:1.36E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.82|P-value:3.82E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-4.25|P-value:1.54E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.63|P-value:4.36E-5 ID:SGTC_447|Compound:ml7|FD-Score:6.13|P-value:1.04E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:9.07|P-value:7.61E-15 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.17|P-value:5.93E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.36|P-value:1.08E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:9.92|P-value:2.03E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:13.00|P-value:1.95E-28 ID:SGTC_637|Compound:1181-0519|FD-Score:8.83|P-value:3.58E-14 ID:SGTC_642|Compound:0335-0876|FD-Score:3.96|P-value:3.96E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:10.50|P-value:3.64E-19 ID:SGTC_669|Compound:0108-0021|FD-Score:7.64|P-value:4.65E-11 ID:SGTC_768|Compound:0384-0033|FD-Score:5.34|P-value:2.98E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.80|P-value:6.20E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:7.83|P-value:1.60E-11 ID:SGTC_794|Compound:k038-0031|FD-Score:14.00|P-value:1.03E-32 ID:SGTC_837|Compound:0091-0265|FD-Score:5.97|P-value:2.14E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:5.95|P-value:2.32E-7 ID:SGTC_962|Compound:1254-0300|FD-Score:3.73|P-value:7.86E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:31.60|P-value:9.87E-159 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.82|P-value:5.83E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:11.90|P-value:2.25E-24 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.18|P-value:5.77E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.94|P-value:4.22E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.90|P-value:4.81E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.47|P-value:1.74E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:4.55|P-value:5.81E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.47|P-value:1.77E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.77|P-value:5.10E-7 ID:SGTC_1750|Compound:st081859|FD-Score:5.48|P-value:1.73E-6 ID:SGTC_1754|Compound:st042065|FD-Score:18.50|P-value:6.57E-56 ID:SGTC_1760|Compound:st045453|FD-Score:23.80|P-value:1.29E-90 ID:SGTC_1767|Compound:st044992|FD-Score:-3.76|P-value:7.09E-4 ID:SGTC_1775|Compound:st081588|FD-Score:7.30|P-value:3.07E-10 ID:SGTC_1781|Compound:st038725|FD-Score:9.74|P-value:7.29E-17 ID:SGTC_1797|Compound:st048695|FD-Score:31.00|P-value:4.22E-152 ID:SGTC_1800|Compound:st050079|FD-Score:6.09|P-value:1.24E-7 ID:SGTC_1801|Compound:st050089|FD-Score:14.30|P-value:3.46E-34 ID:SGTC_1803|Compound:st050068|FD-Score:12.50|P-value:1.04E-26 ID:SGTC_1809|Compound:st050081|FD-Score:8.87|P-value:2.77E-14 ID:SGTC_1834|Compound:st055981|FD-Score:-3.86|P-value:5.26E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.84|P-value:5.81E-4 ID:SGTC_1991|Compound:st073000|FD-Score:28.90|P-value:1.08E-132 ID:SGTC_2006|Compound:4011487|FD-Score:7.37|P-value:2.08E-10 ID:SGTC_2036|Compound:5160441|FD-Score:8.44|P-value:4.31E-13 ID:SGTC_2065|Compound:5221596|FD-Score:-3.71|P-value:8.23E-4 ID:SGTC_2155|Compound:5570423|FD-Score:4.73|P-value:3.04E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.84|P-value:3.66E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:17.70|P-value:2.32E-51 ID:SGTC_2257|Compound:7960413|FD-Score:9.05|P-value:8.46E-15 ID:SGTC_2259|Compound:7964009|FD-Score:3.77|P-value:7.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.65|P-value:4.05E-5 ID:SGTC_2377|Compound:9073351|FD-Score:4.42|P-value:8.93E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-5.49|P-value:1.56E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.48|P-value:1.90E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.89|P-value:4.89E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.25|P-value:5.66E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.84|P-value:2.03E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.91|P-value:2.79E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.45|P-value:8.27E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.43|P-value:8.79E-5 ID:SGTC_2805|Compound:7950783|FD-Score:5.66|P-value:8.12E-7 ID:SGTC_2813|Compound:7971799|FD-Score:6.38|P-value:3.15E-8 ID:SGTC_2984|Compound:9022109|FD-Score:3.65|P-value:9.99E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.40|P-value:2.97E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.10|P-value:2.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.24|P-value:1.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.44|P-value:1.40E-10 ID:SGTC_61|Compound:0978-8327|FD-Score:4.60|P-value:4.80E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:9.24|P-value:2.48E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:9.10|P-value:6.20E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:7.29|P-value:3.18E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.78|P-value:2.46E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.91|P-value:1.04E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.53|P-value:5.98E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:8.93|P-value:1.94E-14 ID:SGTC_146|Compound:3448-8650|FD-Score:13.10|P-value:5.78E-29 ID:SGTC_158|Compound:k038-0087|FD-Score:8.69|P-value:8.71E-14 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:4.05E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:13.00|P-value:2.31E-28 ID:SGTC_181|Compound:1447-1644|FD-Score:5.86|P-value:3.43E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:4.36|P-value:1.09E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.08|P-value:2.74E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:25.30|P-value:4.98E-102 ID:SGTC_232|Compound:clozapine|FD-Score:12.50|P-value:1.33E-26 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.66|P-value:3.96E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.96|P-value:2.17E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.61|P-value:4.75E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.17|P-value:8.33E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:15.00|P-value:3.23E-37 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.10|P-value:2.50E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.40|P-value:9.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.13|P-value:4.82E-15 ID:SGTC_312|Compound:4092-0653|FD-Score:11.70|P-value:2.30E-23 ID:SGTC_313|Compound:3474-0040|FD-Score:20.00|P-value:1.34E-64 ID:SGTC_320|Compound:4092-0846|FD-Score:9.16|P-value:4.04E-15 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.08|P-value:2.67E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:7.12|P-value:7.81E-10 ID:SGTC_347|Compound:4534-1311|FD-Score:6.49|P-value:1.87E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:9.96|P-value:1.51E-17 ID:SGTC_360|Compound:0957-0399|FD-Score:-5.04|P-value:9.37E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:6.46|P-value:2.22E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:22.20|P-value:1.32E-79 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.11|P-value:7.28E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:3.69|P-value:8.94E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.50|P-value:1.49E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:6.45|P-value:2.31E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.94|P-value:1.36E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.82|P-value:3.82E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-4.25|P-value:1.54E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.63|P-value:4.36E-5 ID:SGTC_447|Compound:ml7|FD-Score:6.13|P-value:1.04E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:9.07|P-value:7.61E-15 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.17|P-value:5.93E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.36|P-value:1.08E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:9.92|P-value:2.03E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:13.00|P-value:1.95E-28 ID:SGTC_637|Compound:1181-0519|FD-Score:8.83|P-value:3.58E-14 ID:SGTC_642|Compound:0335-0876|FD-Score:3.96|P-value:3.96E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:10.50|P-value:3.64E-19 ID:SGTC_669|Compound:0108-0021|FD-Score:7.64|P-value:4.65E-11 ID:SGTC_768|Compound:0384-0033|FD-Score:5.34|P-value:2.98E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.80|P-value:6.20E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:7.83|P-value:1.60E-11 ID:SGTC_794|Compound:k038-0031|FD-Score:14.00|P-value:1.03E-32 ID:SGTC_837|Compound:0091-0265|FD-Score:5.97|P-value:2.14E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:5.95|P-value:2.32E-7 ID:SGTC_962|Compound:1254-0300|FD-Score:3.73|P-value:7.86E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:31.60|P-value:9.87E-159 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.82|P-value:5.83E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:11.90|P-value:2.25E-24 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.18|P-value:5.77E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.94|P-value:4.22E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.90|P-value:4.81E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.47|P-value:1.74E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:4.55|P-value:5.81E-5 ID:SGTC_1707|Compound:st032323|FD-Score:5.47|P-value:1.77E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.77|P-value:5.10E-7 ID:SGTC_1750|Compound:st081859|FD-Score:5.48|P-value:1.73E-6 ID:SGTC_1754|Compound:st042065|FD-Score:18.50|P-value:6.57E-56 ID:SGTC_1760|Compound:st045453|FD-Score:23.80|P-value:1.29E-90 ID:SGTC_1767|Compound:st044992|FD-Score:-3.76|P-value:7.09E-4 ID:SGTC_1775|Compound:st081588|FD-Score:7.30|P-value:3.07E-10 ID:SGTC_1781|Compound:st038725|FD-Score:9.74|P-value:7.29E-17 ID:SGTC_1797|Compound:st048695|FD-Score:31.00|P-value:4.22E-152 ID:SGTC_1800|Compound:st050079|FD-Score:6.09|P-value:1.24E-7 ID:SGTC_1801|Compound:st050089|FD-Score:14.30|P-value:3.46E-34 ID:SGTC_1803|Compound:st050068|FD-Score:12.50|P-value:1.04E-26 ID:SGTC_1809|Compound:st050081|FD-Score:8.87|P-value:2.77E-14 ID:SGTC_1834|Compound:st055981|FD-Score:-3.86|P-value:5.26E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.84|P-value:5.81E-4 ID:SGTC_1991|Compound:st073000|FD-Score:28.90|P-value:1.08E-132 ID:SGTC_2006|Compound:4011487|FD-Score:7.37|P-value:2.08E-10 ID:SGTC_2036|Compound:5160441|FD-Score:8.44|P-value:4.31E-13 ID:SGTC_2065|Compound:5221596|FD-Score:-3.71|P-value:8.23E-4 ID:SGTC_2155|Compound:5570423|FD-Score:4.73|P-value:3.04E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.84|P-value:3.66E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:17.70|P-value:2.32E-51 ID:SGTC_2257|Compound:7960413|FD-Score:9.05|P-value:8.46E-15 ID:SGTC_2259|Compound:7964009|FD-Score:3.77|P-value:7.13E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.65|P-value:4.05E-5 ID:SGTC_2377|Compound:9073351|FD-Score:4.42|P-value:8.93E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-5.49|P-value:1.56E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.48|P-value:1.90E-8 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.89|P-value:4.89E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.25|P-value:5.66E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.84|P-value:2.03E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.91|P-value:2.79E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.45|P-value:8.27E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.43|P-value:8.79E-5 ID:SGTC_2805|Compound:7950783|FD-Score:5.66|P-value:8.12E-7 ID:SGTC_2813|Compound:7971799|FD-Score:6.38|P-value:3.15E-8 ID:SGTC_2984|Compound:9022109|FD-Score:3.65|P-value:9.99E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.40|P-value:2.97E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.10|P-value:2.46E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.24|P-value:1.66E-4

Top fitness defect scores for YGL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1130 3454-2858 31.60 15.9 µM 9.87E-159 NEO1 1 7.46E-220
2 SGTC_1797 st048695 31.00 56.8 µM 4.22E-152 NEO1 2 1.23E-210
3 SGTC_1991 st073000 28.90 8.9 µM 1.08E-132 NEO1 1 1.18E-183
4 SGTC_221 trifluoperazine 25.30 10.3 µM 4.98E-102 NEO1-PIK1 4 4.92E-141
5 SGTC_1760 st045453 23.80 10.4 µM 1.29E-90 NEO1-PIK1 5 3.59E-125
6 SGTC_367 0335-0881 22.20 7.1 µM 1.32E-79 ubiquinone biosynthesis & proteasome 1 7.18E-110
7 SGTC_313 3474-0040 20.00 5.0 µM 1.34E-64 NEO1-PIK1 1 5.11E-89
8 SGTC_1754 st042065 18.50 16.1 µM 6.57E-56 NEO1-PIK1 4 6.06E-77
9 SGTC_2250 alverine citrate 17.70 130.0 µM 2.32E-51 1 1.26E-70
10 SGTC_301 4119-0100 15.00 24.5 µM 3.23E-37 NEO1 6 5.54E-51
11 SGTC_1801 st050089 14.30 28.4 µM 3.46E-34 NEO1-PIK1 1 8.95E-47
12 SGTC_794 k038-0031 14.00 316.0 µM 1.03E-32 ubiquinone biosynthesis & proteasome 5 9.99E-45
13 SGTC_146 3448-8650 13.10 53.1 µM 5.78E-29 NEO1-PIK1 9 1.59E-39
14 SGTC_568 1193-0097 13.00 7.5 µM 1.95E-28 ERAD & cell cycle 9 8.61E-39
15 SGTC_172 1112-0046 13.00 2.6 µM 2.31E-28 NEO1 2 1.09E-38
16 SGTC_1803 st050068 12.50 52.4 µM 1.04E-26 NEO1-PIK1 10 2.14E-36
17 SGTC_232 clozapine 12.50 119.0 µM 1.33E-26 NEO1 14 3.01E-36
18 SGTC_1161 k007-0610 11.90 110.0 µM 2.25E-24 ERAD & cell cycle 11 3.73E-33
19 SGTC_312 4092-0653 11.70 6.8 µM 2.30E-23 ergosterol depletion effects on membrane 8 9.40E-32
20 SGTC_649 1123-0311 10.50 367.0 µM 3.64E-19 endomembrane recycling 9 6.26E-26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.733 0 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.614 0 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.540 1.05E-252 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.504 1.32E-215 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.491 5.07E-202 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.462 1.32E-176 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.455 1.37E-170 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.445 2.11E-162 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.440 1.61E-158 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.439 1.21E-157 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.431 9.36E-152 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.426 1.65E-147 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.414 7.19E-139 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.407 2.63E-134 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.405 3.68E-132 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2