YGL020C / GET1

Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL020C / GET1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.96|P-value:7.46E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.00|P-value:2.61E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.74|P-value:2.56E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:7.56|P-value:1.51E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:3.93|P-value:3.30E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.41|P-value:6.22E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.96|P-value:3.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.61|P-value:8.95E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.10|P-value:1.85E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.72|P-value:6.37E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.62|P-value:8.60E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:5.55|P-value:6.23E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.09|P-value:4.74E-8 ID:SGTC_446|Compound:go6976|FD-Score:4.61|P-value:2.95E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.21|P-value:2.74E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.63|P-value:8.48E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.06|P-value:2.10E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:9.55|P-value:1.97E-17 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.80|P-value:2.59E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.74|P-value:1.82E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.62|P-value:8.69E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.63|P-value:2.99E-9 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.52|P-value:6.25E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.76|P-value:5.70E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.85|P-value:2.54E-12 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.77|P-value:5.53E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.19|P-value:2.87E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.82|P-value:4.65E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.60|P-value:3.57E-9 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.88|P-value:3.87E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.80|P-value:2.56E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.79|P-value:1.50E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.40|P-value:1.18E-6 ID:SGTC_1547|Compound:harmine|FD-Score:5.81|P-value:1.86E-7 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.65|P-value:7.95E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.66|P-value:7.77E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.81|P-value:4.79E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.12|P-value:3.95E-6 ID:SGTC_1752|Compound:st044819|FD-Score:5.71|P-value:3.01E-7 ID:SGTC_1763|Compound:st044482|FD-Score:5.00|P-value:6.53E-6 ID:SGTC_1765|Compound:st044815|FD-Score:8.58|P-value:2.15E-14 ID:SGTC_1827|Compound:berberine|FD-Score:-5.40|P-value:4.88E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.72|P-value:3.36E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:7.47E-11 ID:SGTC_1931|Compound:st074438|FD-Score:3.80|P-value:5.00E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.61|P-value:8.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.75|P-value:5.80E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.62|P-value:2.85E-5 ID:SGTC_2110|Compound:5483698|FD-Score:4.85|P-value:1.18E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.84|P-value:4.41E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.67|P-value:7.37E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.07|P-value:2.05E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.31|P-value:4.21E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.73|P-value:8.43E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.04|P-value:5.47E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.67|P-value:7.49E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.33|P-value:1.61E-6 ID:SGTC_2795|Compound:7780010|FD-Score:4.64|P-value:2.68E-5 ID:SGTC_2802|Compound:7925815|FD-Score:5.10|P-value:4.25E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.89|P-value:1.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.96|P-value:3.27E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.08|P-value:2.00E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.51|P-value:6.46E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.61|P-value:8.87E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.80|P-value:1.99E-7 ID:SGTC_2977|Compound:9011197|FD-Score:4.19|P-value:1.36E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.21|P-value:1.22E-10 ID:SGTC_3197|Compound:9113331|FD-Score:5.25|P-value:2.26E-6 ID:SGTC_3216|Compound:9129716|FD-Score:6.23|P-value:2.40E-8 ID:SGTC_3217|Compound:9129673|FD-Score:4.79|P-value:1.49E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-6.99|P-value:1.36E-10 ID:SGTC_3234|Compound:9132280|FD-Score:4.30|P-value:9.16E-5 ID:SGTC_3317|Compound:9138495|FD-Score:5.75|P-value:2.51E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.90|P-value:3.65E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.96|P-value:7.46E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.00|P-value:2.61E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.74|P-value:2.56E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:7.56|P-value:1.51E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:3.93|P-value:3.30E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.41|P-value:6.22E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.96|P-value:3.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.61|P-value:8.95E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.10|P-value:1.85E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.72|P-value:6.37E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.62|P-value:8.60E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:5.55|P-value:6.23E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.09|P-value:4.74E-8 ID:SGTC_446|Compound:go6976|FD-Score:4.61|P-value:2.95E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.21|P-value:2.74E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.63|P-value:8.48E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.06|P-value:2.10E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:9.55|P-value:1.97E-17 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.80|P-value:2.59E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.74|P-value:1.82E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.62|P-value:8.69E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.63|P-value:2.99E-9 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.52|P-value:6.25E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.76|P-value:5.70E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.85|P-value:2.54E-12 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.77|P-value:5.53E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.19|P-value:2.87E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.82|P-value:4.65E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.60|P-value:3.57E-9 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.88|P-value:3.87E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.80|P-value:2.56E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.79|P-value:1.50E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.40|P-value:1.18E-6 ID:SGTC_1547|Compound:harmine|FD-Score:5.81|P-value:1.86E-7 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.65|P-value:7.95E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.66|P-value:7.77E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.81|P-value:4.79E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.12|P-value:3.95E-6 ID:SGTC_1752|Compound:st044819|FD-Score:5.71|P-value:3.01E-7 ID:SGTC_1763|Compound:st044482|FD-Score:5.00|P-value:6.53E-6 ID:SGTC_1765|Compound:st044815|FD-Score:8.58|P-value:2.15E-14 ID:SGTC_1827|Compound:berberine|FD-Score:-5.40|P-value:4.88E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.72|P-value:3.36E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.30|P-value:7.47E-11 ID:SGTC_1931|Compound:st074438|FD-Score:3.80|P-value:5.00E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.61|P-value:8.84E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.75|P-value:5.80E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.62|P-value:2.85E-5 ID:SGTC_2110|Compound:5483698|FD-Score:4.85|P-value:1.18E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.84|P-value:4.41E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.67|P-value:7.37E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.07|P-value:2.05E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.31|P-value:4.21E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.73|P-value:8.43E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.04|P-value:5.47E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.67|P-value:7.49E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.33|P-value:1.61E-6 ID:SGTC_2795|Compound:7780010|FD-Score:4.64|P-value:2.68E-5 ID:SGTC_2802|Compound:7925815|FD-Score:5.10|P-value:4.25E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.89|P-value:1.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.96|P-value:3.27E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.08|P-value:2.00E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.51|P-value:6.46E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.61|P-value:8.87E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.80|P-value:1.99E-7 ID:SGTC_2977|Compound:9011197|FD-Score:4.19|P-value:1.36E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.21|P-value:1.22E-10 ID:SGTC_3197|Compound:9113331|FD-Score:5.25|P-value:2.26E-6 ID:SGTC_3216|Compound:9129716|FD-Score:6.23|P-value:2.40E-8 ID:SGTC_3217|Compound:9129673|FD-Score:4.79|P-value:1.49E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-6.99|P-value:1.36E-10 ID:SGTC_3234|Compound:9132280|FD-Score:4.30|P-value:9.16E-5 ID:SGTC_3317|Compound:9138495|FD-Score:5.75|P-value:2.51E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.90|P-value:3.65E-4

Top fitness defect scores for YGL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_733 4069-0007 9.55 56.1 µM 1.97E-17 ERAD & cell cycle 16 6.42E-22
2 SGTC_1765 st044815 8.58 90.4 µM 2.15E-14 1 4.67E-18
3 SGTC_1179 1021-1431 7.85 9.3 µM 2.54E-12 5 2.02E-15
4 SGTC_91 0417-1751 7.56 58.4 µM 1.51E-11 Golgi 10 1.95E-14
5 SGTC_1844 rapamycin 7.30 4.0 nM 7.47E-11 68 1.49E-13
6 SGTC_2981 9013952 7.21 39.0 µM 1.22E-10 7 2.77E-13
7 SGTC_1026 k007-1105 6.63 30.6 µM 2.99E-9 ERAD & cell cycle 33 1.63E-11
8 SGTC_1408 3909-7976 6.60 48.8 µM 3.57E-9 Golgi 7 2.04E-11
9 SGTC_3216 9129716 6.23 49.5 µM 2.40E-8 RPP1 & pyrimidine depletion 6 2.31E-10
10 SGTC_410 α-linolenic acid 6.09 100.0 µM 4.74E-8 excess fatty acid 12 5.50E-10
11 SGTC_1547 harmine 5.81 94.2 µM 1.86E-7 ergosterol biosynthesis 18 3.13E-9
12 SGTC_2973 9094665 5.80 18.0 µM 1.99E-7 NEO1 7 3.40E-9
13 SGTC_3317 9138495 5.75 8.8 µM 2.51E-7 15 4.59E-9
14 SGTC_71 0417-1750 5.74 47.8 µM 2.56E-7 Golgi 16 4.69E-9
15 SGTC_1752 st044819 5.71 83.0 µM 3.01E-7 12 5.79E-9
16 SGTC_330 1488-0319 5.55 80.1 µM 6.23E-7 RPP1 & pyrimidine depletion 2 1.46E-8
17 SGTC_1542 7-hydroxy-3'-methoxyflavone 5.40 49.7 µM 1.18E-6 3 3.28E-8
18 SGTC_2776 terbinafine 5.33 19.9 µM 1.61E-6 cell wall signaling 26 4.88E-8
19 SGTC_3197 9113331 5.25 49.5 µM 2.26E-6 11 7.53E-8
20 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 5.21 150.0 µM 2.74E-6 Golgi 23 9.62E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.258 3.91E-52 YER083C GET2 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.149 5.09E-18 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.141 1.90E-16 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.136 2.53E-15 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.132 2.06E-14 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.127 1.27E-13 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.124 5.93E-13 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.123 8.16E-13 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.118 5.69E-12 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.118 7.71E-12 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.115 2.19E-11 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.113 4.42E-11 YDL195W SEC31 het Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
0.113 4.75E-11 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.112 7.11E-11 YNR052C POP2 hom RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
0.108 3.99E-10 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly