YGL021W / ALK1

Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL021W / ALK1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:-3.90|P-value:3.74E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.52|P-value:1.74E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:5.24|P-value:6.74E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.19|P-value:5.78E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.09|P-value:8.18E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.43|P-value:2.86E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.42|P-value:2.55E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.39|P-value:2.79E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.92|P-value:3.99E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.11|P-value:7.63E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.32|P-value:4.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.67|P-value:9.71E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.78|P-value:7.41E-7 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.40|P-value:3.21E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.14|P-value:7.97E-4 ID:SGTC_1895|Compound:st058434|FD-Score:5.75|P-value:3.45E-9 ID:SGTC_1903|Compound:st060211|FD-Score:3.89|P-value:4.53E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.95|P-value:3.61E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.39|P-value:3.31E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.39|P-value:3.31E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.62|P-value:1.35E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.43|P-value:2.84E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.22|P-value:7.59E-8 ID:SGTC_2958|Compound:9077254|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-5.15|P-value:8.61E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-3.19|P-value:5.96E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.90|P-value:3.74E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.52|P-value:1.74E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:5.24|P-value:6.74E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.19|P-value:5.78E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.09|P-value:8.18E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.43|P-value:2.86E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.42|P-value:2.55E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.39|P-value:2.79E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.92|P-value:3.99E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.11|P-value:7.63E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.32|P-value:4.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.67|P-value:9.71E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.78|P-value:7.41E-7 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.40|P-value:3.21E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.14|P-value:7.97E-4 ID:SGTC_1895|Compound:st058434|FD-Score:5.75|P-value:3.45E-9 ID:SGTC_1903|Compound:st060211|FD-Score:3.89|P-value:4.53E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.95|P-value:3.61E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.39|P-value:3.31E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.39|P-value:3.31E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.62|P-value:1.35E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.43|P-value:2.84E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.22|P-value:7.59E-8 ID:SGTC_2958|Compound:9077254|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-5.15|P-value:8.61E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-3.19|P-value:5.96E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.28|P-value:4.95E-4

Top fitness defect scores for YGL021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1895 st058434 5.75 18.3 µM 3.45E-9 4 4.38E-9
2 SGTC_319 1348-1596 5.24 45.5 µM 6.74E-8 RSC & ERG11 4 8.13E-8
3 SGTC_2844 9010103 5.22 26.0 µM 7.59E-8 5 9.14E-8
4 SGTC_1367 1812-0510 4.78 76.9 µM 7.41E-7 6 8.60E-7
5 SGTC_2104 5389443 3.95 200.0 µM 3.61E-5 15 3.93E-5
6 SGTC_930 2810-3379 3.92 265.0 µM 3.99E-5 13 4.34E-5
7 SGTC_1903 st060211 3.89 78.3 µM 4.53E-5 31 4.92E-5
8 SGTC_2709 st078560 3.65 56.0 µM 1.23E-4 19 1.32E-4
9 SGTC_2989 9073649 3.63 71.4 µM 1.31E-4 51 1.40E-4
10 SGTC_860 0443-0016 3.63 25.1 µM 1.32E-4 41 1.42E-4
11 SGTC_2386 9075165 3.62 157.4 µM 1.35E-4 13 1.45E-4
12 SGTC_597 k018-0003 3.57 82.8 µM 1.67E-4 RNA pol III & RNase P/MRP 19 1.78E-4
13 SGTC_2958 9077254 3.52 16.7 µM 2.01E-4 42 2.14E-4
14 SGTC_2702 st077768 3.43 96.8 µM 2.84E-4 29 3.00E-4
15 SGTC_807 1315-0151 3.43 48.0 µM 2.86E-4 47 3.03E-4
16 SGTC_1499 4480-0877 3.40 67.3 µM 3.21E-4 15 3.39E-4
17 SGTC_2123 5259487 3.39 200.0 µM 3.31E-4 33 3.49E-4
18 SGTC_2316 5844804 3.39 197.4 µM 3.31E-4 64 3.50E-4
19 SGTC_1035 k081-0041 3.32 55.2 µM 4.24E-4 Golgi 42 4.46E-4
20 SGTC_3203 9113543 3.28 49.5 µM 4.95E-4 54 5.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.40E-10 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.90E-8 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.094 5.00E-8 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.092 1.03E-7 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.092 1.08E-7 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.084 1.10E-6 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.084 1.19E-6 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.083 1.35E-6 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.076 9.92E-6 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.076 1.01E-5 YNL269W BSC4 hom Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
0.074 1.68E-5 YKL049C CSE4 het Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions
0.073 2.56E-5 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.072 3.42E-5 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.070 4.66E-5 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.070 5.41E-5 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates